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Unexpected Single-Ligand Occupancy and Negative Cooperativity in the SARS-CoV-2 Main Protease2023 Journal of Chemical Information and Modeling article Materials Science Enzyme Structure and Function Open access
Simone Albani, Elisa Costanzi, Gia Linh Hoang, Maria Kuzikov, Marcus Frings, Narjes Ansari, +9 more
14citations -
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease2023 Zenodo (CERN European Organization for Nuclear Research) dataset Medicine SARS-CoV-2 and COVID-19 Research Open access
Simone Albani, Elisa Costanzi, Gia Linh Hoang, Maria Kuzikov, Marcus Frings, Narjes Ansari, +9 more
0citations -
Unexpected single ligand occupancy and negative cooperativity in the SARS-CoV-2 Main protease2023 Zenodo (CERN European Organization for Nuclear Research) dataset Medicine SARS-CoV-2 and COVID-19 Research Open access
Simone Albani, Elisa Costanzi, Gia Linh Hoang, Maria Kuzikov, Marcus Frings, Narjes Ansari, +9 more
0citations -
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses2022 Journal of the American Chemical Society article Computer Science Computational Drug Discovery Methods Open access cited by 15 patents
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, V. Talibov, +19 more
253citations -
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L2021 International Journal of Molecular Sciences article Medicine SARS-CoV-2 and COVID-19 Research Open access
Elisa Costanzi, Maria Kuzikov, Francesca Esposito, Simone Albani, Nicola Demitri, Barbara Giabbai, +5 more
91citations -
The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response
Mariska van Huizen, Xavier Martinez Vendrell, Heidi L. M. De Gruyter, A. Linda Boomaars‐van der Zanden, Eric J. Snijder, Marjolein Kikkert, +1 more
9citations -
Water-triggered, irreversible conformational change of SARS-CoV-2 main protease on passing from the solid state to aqueous solution2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Protein Structure and Dynamics Open access
Narjes Ansari, Valerio Rizzi, Paolo Carloni, Michele Parrinello
4citations -
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication2023 Phytomedicine article Pharmacology, Toxicology and Pharmaceutics Hops Chemistry and Applications Open access
Anna-Maria Herzog, Katharina Göbel, Luigi Marongiu, Natalia Ruétalo, Marta Campos Alonso, Christian Leischner, +8 more
14citations -
Human coronavirus 229E infection inactivates pyroptosis executioner gasdermin D but ultimately leads to lytic cell death partly mediated by gasdermin E2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Biochemistry, Genetics and Molecular Biology Inflammasome and immune disorders Open access
Xavier Martiáñez–Vendrell, Jonna Bloeme, Roy Hutchinson, Coralie Guy, Andrew G. Bowie, Marjolein Kikkert
2citations -
Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen2021 ACS Pharmacology & Translational Science article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 8 patents
Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Bernhard Ellinger, +26 more
160citations -
HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms2025 International Journal of Molecular Sciences article Immunology and Microbiology interferon and immune responses Open access
Xavier Martiáñez–Vendrell, Puck B. van Kasteren, Sebenzile K. Myeni, Marjolein Kikkert
6citations -
Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E2024 Viruses article Biochemistry, Genetics and Molecular Biology Inflammasome and immune disorders Open access
Xavier Martiáñez–Vendrell, Roy Hutchinson, Coralie Guy, Andrew G. Bowie, Marjolein Kikkert
5citations -
A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics2020 bioRxiv (Cold Spring Harbor Laboratory) preprint Computer Science Computational Drug Discovery Methods Open access
Jonas Goßen, Simone Albani, Anton Hanke, Benjamin Philipp Joseph, Cathrine C. Bergh, Maria Kuzikov, +14 more
5citations -
A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics2021 ACS Pharmacology & Translational Science article Computer Science Computational Drug Discovery Methods Open access
Jonas Goßen, Simone Albani, Anton Hanke, Benjamin Philipp Joseph, Cathrine C. Bergh, Maria Kuzikov, +14 more
62citations -
α‑Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment2020 Journal of Medicinal Chemistry article Medicine SARS-CoV-2 and COVID-19 Research Open access cited by 37 patents
Linlin Zhang, Daizong Lin, Yuri Kusov, Yong Nian, Qingjun Ma, Jiang Wang, +8 more
616citations