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Hotspot DNA Methyltransferase 3A (DNMT3A) and Isocitrate Dehydrogenase 1 and 2 (IDH1/2) Mutations in Acute Myeloid Leukemia and Their Relevance as Targets for Immunotherapy
Nadine E. Struckman, Rob C. M. de Jong, M. Willy Honders, Sophie-Anne I. Smith, Dyantha I. van der Lee, Georgia Koutsoumpli, +5 more
7citations -
Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy: results from the HOVON 109 study
Fatemeh Saberi Hosnijeh, Lina van der Straten, Arnon Philip Kater, Marinus H. J. van Oers, Ward F.M. Posthuma, Martine E.D. Chamuleau, +16 more
8citations -
Mutated DNMT3A creates a public HLADQ- binding neoantigen on acute myeloid leukemia2025 Frontiers in Immunology article Immunology and Microbiology Immunotherapy and Immune Responses Open access
Dyantha I. van der Lee, Eva M. Argiro, Sebastiaan N. J. Laan, M. Willy Honders, Rob C. M. de Jong, Nadine Struckman, +2 more
3citations -
A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia2021 Clinical Cancer Research article Medicine Chronic Lymphocytic Leukemia Research Open access cited by 20 patents
Iris de Weerdt, Roeland Lameris, Jurjen M. Ruben, Renate de Boer, Jan Kloosterman, Lisa A. King, +5 more
62citations -
T-cell receptors targeting distinct FLT3-D835Y neoantigens display differential reactivity toward acute myeloid leukemia2026 Blood Immunology & Cellular Therapy article Medicine Acute Myeloid Leukemia Research Open access
Nadine Struckman, M. Willy Honders, Georgia Koutsoumpli, Rob C. M. de Jong, Dyantha I. van der Lee, Michel G.D. Kester, +11 more
0citations -
WT1-specific TCRs directed against newly identified peptides install antitumor reactivity against acute myeloid leukemia and ovarian carcinoma2022 Journal for ImmunoTherapy of Cancer article Immunology and Microbiology Immunotherapy and Immune Responses Open access cited by 6 patents
Rosa A. van Amerongen, Renate S. Hagedoorn, Dennis F.G. Remst, Danique C Assendelft, Dirk M. van der Steen, Anne K. Wouters, +7 more
26citations -
Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells2020 Frontiers in Immunology article Immunology and Microbiology Immunotherapy and Immune Responses Open access cited by 2 patents
Saskia Schmitt, Siret Tahk, Alina Lohner, Gerulf Hänel, Andreas Maiser, Martina Hauke, +9 more
20citations -
Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia2022 Science Translational Medicine article Medicine CAR-T cell therapy research Open access cited by 2 patents
Giorgio Ottaviano, Christos Georgiadis, Soragia Athina Gkazi, Farhatullah Syed, Hong Zhan, Annie Etuk, +52 more
204citations -
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes2021 Nature Biotechnology article Medicine CAR-T cell therapy research Open access cited by 7 patents
Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, +27 more
36citations -
The Changing Face of Oncology Research, Drug Development, and Clinical Practice: Toward Patient‐Focused Precision Therapeutics2020 Clinical Pharmacology & Therapeutics article Mathematics Statistical Methods in Clinical Trials Open access
Karthik Venkatakrishnan, Piet H. van der Graaf, Sarah A. Holstein
4citations -
An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML2021 Cancers article Immunology and Microbiology Immunotherapy and Immune Responses Open access cited by 1 patent
Dyantha I. van der Lee, Georgia Koutsoumpli, Rogier M. Reijmers, M. Willy Honders, Dennis F.G. Remst, Tassilo L A Wachsmann, +13 more
16citations