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Papers matching “new approach methodologies” 18

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New approach methodologies in human regulatory toxicology – Not if, but how and when!
2023 Environment International article Veterinary Animal testing and alternatives Open access

Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen�, Elisabet Berggren, Albert Braeuning, Wibke Busch, +23 more

381

citations
Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies
2025 Environmental Toxicology and Chemistry article Veterinary Animal testing and alternatives Open access

John Kenneth Colbourne, Sylvia E. Escher, Robert Lee, Mathieu Vinken, Bob van de Water, Jonathan H. Freedman

11

citations
Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action
2021 Toxicology in Vitro article Veterinary Animal testing and alternatives Open access

Sylvia E. Escher, Alejandro Aguayo‐Orozco, Emilio Benfenati, Annette Bitsch, Thomas A. Braunbeck, Katharina Brotzmann, +26 more

39

citations
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies
2021 ALTEX article Veterinary Animal testing and alternatives Open access

Wanda van der Stel

18

citations
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
2020 Archives of Toxicology article Veterinary Animal testing and alternatives Open access

Barbara M. A. van Vugt‐Lussenburg, Tanja Waldmann, Wiebke Albrecht, Jan Boei, Bas ter Braak, Maja Brajnik, +38 more

52

citations
Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes
2021 Toxicology Research article Veterinary Animal testing and alternatives Open access

Monique van der Voet, Marc Teunis, Johanna Louter-van de Haar, Nienke Stigter, Diksha Bhalla, Martijn Rooseboom, +5 more

11

citations
Applicability of NAMs to support a read-across based hazard assessment workflow for systemic toxicity: a conazole case study
2026 Archives of Toxicology article Veterinary Animal testing and alternatives Open access

Barira Islam, Jenny Irwan, Lukas Wijaya, Bas ter Braak, Amer Jamalpoor, Tamara Meijer, +26 more

0

citations
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
2022 Environmental Research article Veterinary Animal testing and alternatives Open access

Lola Bajard, Ondřej Adamovský, Karine Audouze, Kirsten A. Baken, Robert Barouki, Joost B. Beltman, +28 more

102

citations
Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
2024 Cutaneous and Ocular Toxicology article Veterinary Animal testing and alternatives Open access

Hans Raabe, Gertrude‐Emilia Costin, David Allen, Anna Lowit, Marco Corvaro, Julie Breeden-Alemi, +6 more

14

citations
Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA)
2026 ALTEX article Veterinary Animal testing and alternatives Open access

Mirjam Luijten, Matthias Herzler, Femke Affourtit, Dave Allen, Muhammad Waqar Ashraf, Nicholas S. Ball, +47 more

1

citations
Setting the stage for next-generation risk assessment with non-animal approaches: the EU-ToxRisk project experience
2020 Archives of Toxicology article Veterinary Animal testing and alternatives Open access

Martijn J. Moné, Giorgia Pallocca, Sylvia E. Escher, Thomas E. Exner, Matthias Herzler, Susanne Hougaard Bennekou, +5 more

60

citations
The long way from raw data to NAM-based information: Overview on data layers and processing steps
2025 ALTEX article Veterinary Animal testing and alternatives Open access

Jonathan H. Blum, Markus Brüll, Jan Georg Hengstler, Daniel Reto Dietrich, Andreas J Gruber, Michele Dipalo, +29 more

2

citations
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective
2022 ALTEX article Veterinary Animal testing and alternatives Open access

Giorgia Pallocca

64

citations
Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids
2022 Toxicology in Vitro article Veterinary Animal testing and alternatives Open access

Samantha V. Llewellyn, Ali Kermanizadeh, Victor Chibueze Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, +8 more

11

citations
Potential systemic availability classification of chemicals for safety assessment
2025 Environment International article Veterinary Animal testing and alternatives Open access

René Geci, Alicia Paini, Andrew Paul Worth, Lars Kuepfer, Stephan Schaller

1

citations
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network
2025 Toxicological Sciences article Veterinary Animal testing and alternatives Open access

Hugo W van Kessel, Steven J. Kunnen, Giulia Callegaro, Bob van de Water

2

citations
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network
2025 Leiden Repository (Leiden University) article Veterinary Animal testing and alternatives Open access

0

citations
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders
2024 Alternatives to Laboratory Animals article Veterinary Animal testing and alternatives Open access

Michael Guy Diemar, Mathieu Vinken, Marc Teunis, Cyrille A. M. Krul, François Busquet, Julia Dominika Zajac, +41 more

8

citations

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