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Papers matching “needs assessment” 26

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Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
2022 Environmental Research article Veterinary Animal testing and alternatives Open access

Lola Bajard, Ondřej Adamovský, Karine Audouze, Kirsten A. Baken, Robert Barouki, Joost B. Beltman, +28 more

102

citations
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective
2022 ALTEX article Veterinary Animal testing and alternatives Open access

Giorgia Pallocca

64

citations
Stakeholder input towards further refinement and consolidation of the alternative safety profiling algorithm (ASPA) for next generation risk assessment (NGRA)
2026 ALTEX article Veterinary Animal testing and alternatives Open access

Mirjam Luijten, Matthias Herzler, Femke Affourtit, Dave Allen, Muhammad Waqar Ashraf, Nicholas S. Ball, +47 more

1

citations
Protectiveness of NAM-based hazard assessment – which testing scope is required?
2023 ALTEX article Veterinary Animal testing and alternatives Open access

Walter Zobl, Annette Bitsch, Jonathan H. Blum, J.J.W.A. Boei, Liliana Capinha, Giada Carta, +17 more

7

citations
Severity assessment using three common behavioral or locomotor tests after laparotomy in rats: a pilot study
2020 Laboratory Animals article Veterinary Animal testing and alternatives

Leonie Zieglowski, Anna Maria Kümmecke, Lisa Ernst, Mareike Schulz, Steven Roger Talbot, Rupert Palme, +2 more

17

citations
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network
2025 Toxicological Sciences article Veterinary Animal testing and alternatives Open access

Hugo W van Kessel, Steven J. Kunnen, Giulia Callegaro, Bob van de Water

2

citations
Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network
2025 Leiden Repository (Leiden University) article Veterinary Animal testing and alternatives Open access

0

citations
Potential systemic availability classification of chemicals for safety assessment
2025 Environment International article Veterinary Animal testing and alternatives Open access

René Geci, Alicia Paini, Andrew Paul Worth, Lars Kuepfer, Stephan Schaller

1

citations
Beyond single metrics: Multi-parameter home-cage monitoring improves welfare assessment
2026 Laboratory Animals article Veterinary Animal testing and alternatives Open access

Steven R. Talbot, Rene Hany Tolba, André Bleich

1

citations
Potential Systemic Availability Classification of Chemicals for Safety Assessment
2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Veterinary Animal testing and alternatives Open access

René Geci, Alicia Paini, Andrew Paul Worth, Lars Kuepfer, Stephan Schaller

0

citations
New approach methodologies in human regulatory toxicology – Not if, but how and when!
2023 Environment International article Veterinary Animal testing and alternatives Open access

Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen�, Elisabet Berggren, Albert Braeuning, Wibke Busch, +23 more

381

citations
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders
2024 Alternatives to Laboratory Animals article Veterinary Animal testing and alternatives Open access

Michael Guy Diemar, Mathieu Vinken, Marc Teunis, Cyrille A. M. Krul, François Busquet, Julia Dominika Zajac, +41 more

8

citations
Animal-free strategies in food safety & nutrition: What are we waiting for? Part I: Food safety
2020 Trends in Food Science & Technology article Veterinary Animal testing and alternatives Open access

Alie de Boer, Lisette Krul, Markus Fehr, Lucie Geurts, Nynke I. Kramer, María Aránzazu Tabernero Urbieta, +5 more

26

citations
Quantitative adverse outcome pathway modeling of cisplatin-induced nephrotoxicity: developing in vitro and in vivo models for predictive extrapolation
2026 Zenodo (CERN European Organization for Nuclear Research) dataset Veterinary Animal testing and alternatives Open access

Filippo Di Tillio, Lukas S. Wijaya, Steven J. Kunnen, Carl Joshua Eugenio, Giorgio Buzzanca, Imke B. Bruns, +6 more

0

citations
Quantitative adverse outcome pathway modeling of cisplatin-induced nephrotoxicity: developing in vitro and in vivo models for predictive extrapolation
2026 Zenodo (CERN European Organization for Nuclear Research) dataset Veterinary Animal testing and alternatives Open access

Filippo Di Tillio, Lukas S. Wijaya, Steven J. Kunnen, Carl Joshua Eugenio, Giorgio Buzzanca, Imke B. Bruns, +6 more

0

citations
Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes
2021 Toxicology Research article Veterinary Animal testing and alternatives Open access

Monique van der Voet, Marc Teunis, Johanna Louter-van de Haar, Nienke Stigter, Diksha Bhalla, Martijn Rooseboom, +5 more

11

citations
Refining humane endpoint detection by time-series forecasting and threshold definition using a multivariate severity score
2026 Frontiers in Physiology article Veterinary Animal testing and alternatives Open access

Sara Lutscher, Lisa Goral, Christine Häger, Anna Munk, Miriam Heider, Nora Weegh, +5 more

0

citations
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
2020 Archives of Toxicology article Veterinary Animal testing and alternatives Open access

Barbara M. A. van Vugt‐Lussenburg, Tanja Waldmann, Wiebke Albrecht, Jan Boei, Bas ter Braak, Maja Brajnik, +38 more

52

citations
The long way from raw data to NAM-based information: Overview on data layers and processing steps
2025 ALTEX article Veterinary Animal testing and alternatives Open access

Jonathan H. Blum, Markus Brüll, Jan Georg Hengstler, Daniel Reto Dietrich, Andreas J Gruber, Michele Dipalo, +29 more

2

citations
Commentary on “Investigator brochures for phase I/II trials lack information on the robustness of preclinical safety studies” by Sievers et al.
2021 British Journal of Clinical Pharmacology editorial Veterinary Animal testing and alternatives Open access

Robert Rißmann, Rob G. J. A. Zuiker

0

citations
Borrow, don't breed: How historical controls can cut concurrent animal numbers_suppl
2026 ALTEX article Veterinary Animal testing and alternatives Open access

Steven Roger Talbot, Sara Lutscher, Lisa Ernst, Lena Kistermann, Tolba Rene

0

citations
Borrow, don't breed: How historical controls can cut concurrent animal numbers
2026 ALTEX article Veterinary Animal testing and alternatives Open access

Steven Roger Talbot, Sara Lutscher, Lisa Ernst, Lena Kistermann, Tolba Rene

0

citations
Quantitative adverse outcome pathway modeling of cisplatin-induced nephrotoxicity: developing in vitro and in vivo models for predictive extrapolation
2026 Toxicological Sciences article Veterinary Animal testing and alternatives Open access

Filippo Di Tillio, Lukas S. Wijaya, Steven J. Kunnen, Carl Joshua Eugenio, Giorgio Buzzanca, Imke B. Bruns, +6 more

1

citations
Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology
2025 Archives of Toxicology review Veterinary Animal testing and alternatives Open access

Monica Piergiovanni, Milena Mennecozzi, Erio Barale-Thomas, Davide Danovi, Sebastian Dunst, David A. Egan, +17 more

7

citations
Laboratory conditions matter: social housing in male and female laboratory mice in a multicenter study approach
2026 Lab Animal article Veterinary Animal Behavior and Welfare Studies Open access

Anne Stephanie Mallien, Anna Munk, Anne Rix, Miriam Annika Vogt, Natascha Pfeiffer, Verena Buchecker, +14 more

0

citations