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Evaluation of Antiviral Drugs’ Central Nervous System Distribution Using In Vitro Blood–Brain and Blood-CSF Barrier Models: The Impact of Serum Protein Concentration2026 Cellular and Molecular Neurobiology article Neuroscience Barrier Structure and Function Studies Open access
Malik Johid Reza, Ukamaka O. Modebelu, Courtney Vail Fletcher, Nagadenahalli Byrareddy Siddappa, Robbyn Kimberly Anand, Tianyi Zhang, +6 more
0citations -
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations -
Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow2026 Fluids and Barriers of the CNS article Neuroscience Barrier Structure and Function Studies Open access
Jade Admiraal, Promise Emeh, Marleen Bokkers, Sander Ruiter, Thomas Olivier, Karla C. S. Queiroz, +2 more
4citations -
Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer’s, CADASIL, and Traumatic Brain Injury2026 Nature Communications article Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Katrine Dahl Bjørnholm, H. Li, G. Mocci, W. Shao, E. Baldisseri, S. B. Rao, +17 more
0citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations -
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice2023 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Mohammed A. A. Saleh, Berfin Gülave, Olivia Campagne, Clinton F. Stewart, Jeroen Elassaiss‐Schaap, Elizabeth C. M. de Lange
5citations -
Normative modelling of brain morphometry across the lifespan with CentileBrain: algorithm benchmarking and model optimisation2024 The Lancet Digital Health article Neuroscience Functional Brain Connectivity Studies Open access
Ruiyang Ge, Yuetong Yu, Yi Xuan Qi, Yunan Vera Fan, Shiyu Chen, Chuntong Gao, +38 more
118citations -
Ensemble graph neural network model for classification of major depressive disorder using whole-brain functional connectivity2023 Frontiers in Psychiatry article Neuroscience Functional Brain Connectivity Studies Open access cited by 1 patent
Sujitha Venkatapathy, Mikhail Votinov, Lisa Wagels, SangYun Kim, Munseob Lee, Ute Habel, +2 more
44citations -
Do Brain Extracellular Fluid Concentrations Predict PET ‐Inferred Receptor Occupancy in Human CNS ? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands2026 Clinical Pharmacology & Therapeutics article Neuroscience Neurotransmitter Receptor Influence on Behavior Open access
Divakar Budda, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s disease2024 Journal of Biomedical Science article Neuroscience Genetic Neurodegenerative Diseases Open access
Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, +10 more
8citations