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Amlodipine limits microglia activation and cognitive dysfunction in aged hypertensive mice2023 Journal of Hypertension article Neuroscience Neuroinflammation and Neurodegeneration Mechanisms Open access
Daniëlle Kerkhofs, Robin Helgers, Denise J. H. P. Hermes, H.P. Steinbusch, Helma van Essen, Peter J. A. Leenders, +5 more
32citations -
Multi‑omics profiling reveals shared blood-brain barrier stress signatures and disease-specific vascular remodelingin capillary cerebral amyloid angiopathy and GRN-associated frontotemporal dementia
Jannis F. Heuer, Thomas Rust, Loet Coenen, Evelyn M. Wesseling, Peter van Veelen, Rayman T.N. Tjokrodirijo, +5 more
0citations -
Application of contrast-enhanced magnetic resonance imaging in the assessment of blood-cerebrospinal fluid barrier integrity2021 Neuroscience & Biobehavioral Reviews article Neuroscience Cerebrospinal fluid and hydrocephalus Open access
Inge C.M. Verheggen, Whitney M. Freeze, Joost J.A. de Jong, Jacobus F.A. Jansen, Alida Annechien Postma, Martin P.J. van Boxtel, +2 more
19citations -
Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport2024 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
3citations -
Does nonlinear blood-brain barrier transport matter for morphine dosing strategies?2023 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Berfin Gülave, Divakar Budda, Mohammed A. A. Saleh, J. G. Coen van Hasselt, Elizabeth C. M. de Lange
0citations -
Faculty Opinions recommendation of Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis.0citations
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Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis2024 Journal of Neuroinflammation article Neuroscience Barrier Structure and Function Studies Open access
Cathrin Elly Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, +12 more
33citations -
Blood-brain barrier perturbations by uremic toxins: Key contributors in chronic kidney disease-induced neurological disorders?2023 European Journal of Pharmaceutical Sciences article Neuroscience Barrier Structure and Function Studies Open access
Quentin Faucher, Thomas K. van der Made, Elizabeth C. M. de Lange, Rosalinde Masereeuw
42citations -
Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration2020 International Journal of Molecular Sciences article Neuroscience Axon Guidance and Neuronal Signaling Open access
Huayu Zhang, Dianne Vreeken, Abidemi Junaid, Gangqi Wang, Ruben G. de Bruin, Anton Jan van Zonneveld, +1 more
16citations -
Exploring Kp,uu,BBB Values Smaller than Unity in Remoxipride: A Physiologically-Based CNS Model Approach Highlighting Brain Metabolism in Drugs with Passive Blood-Brain Barrier Transport2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Barrier Structure and Function Studies Open access
Mengxu Zhang, Ilona M. Vuist, Vivi Rottschäfer, Elizabeth C. M. de Lange
0citations -
Multimodal evidence for impaired glymphatic brain clearance as a mediator of “inflammaging” in schizophrenia – integrating insights from in vivo neuroimaging, omics, and post-mortem single nucleus-RNA-Seq data2026 bioRxiv (Cold Spring Harbor Laboratory) preprint Neuroscience Cerebrospinal fluid and hydrocephalus Open access
Xiaolin Tan, Malte Simon, Daniel Rosebrock, Mariia Firuleva, Doris Gruber-Schoffnegger, Marisa Fuerst, +7 more
0citations -
D101-10 Breaking Barriers: Characterisation of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers2026 American Journal of Respiratory and Critical Care Medicine article Neuroscience Barrier Structure and Function Studies
Marella C. E. van Ruissen, Menno van Diemen, Liza Botros, I Tomljanovic, Hind Achbo, Dimitra Eleftheriou, +5 more
0citations -
The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology2022 Pharmaceutical Research article Neuroscience Barrier Structure and Function Studies Open access
Makoto Hirasawa, Mohammed A. A. Saleh, Elizabeth C. M. de Lange
7citations