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Updated protocol of the SANO trial: a stepped-wedge cluster randomised trial comparing surgery with active surveillance after neoadjuvant chemoradiotherapy for oesophageal cancer
Ben M. Eyck, Berend J. van der Wilk, Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Henk H. Hartgrink, +18 more
94citations -
MR CLEAN-NO IV: intravenous treatment followed by endovascular treatment versus direct endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion—study protocol for a randomized clinical trial
Kilian M. Treurniet, Natalie E. LeCouffe, Manon Kappelhof, Bart J. Emmer, Adriaan C.G.M. van Es, Jelis Boiten, +12 more
61citations -
MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial
F.A.V. Pirson, Wouter H. Hinsenveld, Robert‐Jan B. Goldhoorn, Julie Staals, Inger R. de Ridder, Wim H. van Zwam, +9 more
61citations -
A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT
Frederik Haupenthal, Jette Rahn, Fabrizio Maggi, Fanny Gelas, Philippe Bourgeois, Christian Hugo, +26 more
61citations -
Minimally invasive versus open pancreatoduodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): study protocol for an international multicenter patient-blinded randomized controlled trial
Nine de Graaf, Anouk M.L.H. Emmen, Marco Ramera, Bergþór Björnsson, Ugo Boggi, Caro L. Bruna, +22 more
50citations -
Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster-randomized trial
F. Jasmijn Smits, Anne Claire Henry, Casper H.J. van Eijck, Marc G. Besselink, Olivier R. Busch, Mark J. Arntz, +25 more
45citations -
The effect of a multidisciplinary lifestyle program for patients with rheumatoid arthritis, an increased risk for rheumatoid arthritis or with metabolic syndrome-associated osteoarthritis: the “Plants for Joints” randomized controlled trial protocol
Wendy Walrabenstein, Marike van der Leeden, Peter J.M. Weijs, Henriët van Middendorp, Carlijn A. Wagenaar, Johanna Maria van Dongen, +4 more
38citations -
TREAT Early Arthralgia to Reverse or Limit Impending Exacerbation to Rheumatoid arthritis (TREAT EARLIER): a randomized, double-blind, placebo-controlled clinical trial protocol
Ellis Niemantsverdriet, Yousra J. Dakkak, Leonie E. Burgers, Femke Bonte‐Mineur, Gerda M. Steup‐Beekman, Sjoerd M. van der Kooij, +4 more
35citations -
LIVE@Home.Path—innovating the clinical pathway for home-dwelling people with dementia and their caregivers: study protocol for a mixed-method, stepped-wedge, randomized controlled trial
Bettina Sandgathe Husebo, Heather G Allore, Wilco P. Achterberg, Renira C. Angeles, Clive G. Ballard, Frøydis Kristine Bruvik, +17 more
26citations -
Combining Hepatic Percutaneous Perfusion with Ipilimumab plus Nivolumab in advanced uveal melanoma (CHOPIN): study protocol for a phase Ib/randomized phase II trial
Thaïs M. L. Tong, Monique K. van der Kooij, Frank M. Speetjens, Arian R. van Erkel, Rutger W. van der Meer, Jacob Lutjeboer, +7 more
23citations -
Pulmonary rehabilitation to improve physical capacity, dyspnea, and quality of life following pulmonary embolism (the PeRehab study): study protocol for a two-center randomized controlled trial
Stacey Haukeland-Parker, Øyvind Jervan, Hege Hølmo Johannessen, Jostein Gleditsch, Knut Stavem, Kjetil Steine, +5 more
23citations -
A pragmatic randomised controlled trial referring to a Personalised Self-management SUPport Programme (P-SUP) for persons enrolled in a disease management programme for type 2 diabetes mellitus and/or for coronary heart disease
Uwe Konerding, Marcus Redaèlli, Karolin Ackermann, Sibel Vildan Altin, Sebastian Appelbaum, Bianca Biallas, +34 more
21citations -
Dose reduction and withdrawal strategy for TNF-inhibitors in psoriatic arthritis and axial spondyloarthritis: design of a pragmatic open-label, randomised, non-inferiority trial
Celia A J Michielsens, Nadine Boers, Nathan den Broeder, Mark H. Wenink, Aatke van der Maas, Elien A. M. Mahler, +5 more
21citations -
Laparoscopic versus open resections in the posterosuperior liver segments within an enhanced recovery programme (ORANGE Segments): study protocol for a multicentre randomised controlled trial
Christoph Kuemmerli, Robert S. Fichtinger, Alma L. Moekotte, Luca Antonio Aldrighetti, Somaiah Aroori, Marc G. Besselink, +19 more
20citations -
Prophylactic abdominal drainage or no drainage after distal pancreatectomy (PANDORINA): a study protocol of a binational multicenter randomized controlled trial
Frederique L. I. M. Vissers, Alberto Balduzzi, Eduard A. van Bodegraven, Jony van Hilst, Suzanne Festen, Mohammad Abu Hilal, +19 more
20citations -
Safety, reactogenicity, and immunogenicity of a 2-dose Ebola vaccine regimen of Ad26.ZEBOV followed by MVA-BN-Filo in healthy adult pregnant women: study protocol for a phase 3 open-label randomized controlled trial
Etienne Karita, Julien M. Nyombayire, Rosine Ingabire, Amelia Mazzei, Tyronza Sharkey, Jeannine Mukamuyango, +12 more
19citations -
Effect of Automated Closed-loop ventilation versus convenTional VEntilation on duration and quality of ventilation in critically ill patients (ACTiVE) – study protocol of a randomized clinical trial
Michela Botta, Anissa M. Tsonas, Jante S. Sinnige, Ashley J.R. De Bie, Alexander J. G. H. Bindels, Lorenzo Ball, +13 more
18citations -
The PRolaCT studies — a study protocol for a combined randomised clinical trial and observational cohort study design in prolactinoma
Ingrid Marijke Zandbergen, Amir H. Zamanipoor Najafabadi, Iris C. M. Pelsma, M. Elske van den Akker‐van Marle, Peter H L T Bisschop, Hieronymus Damianus Boogaarts, +17 more
18citations