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Papers matching “substrate binding” 35

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Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels
2021 Chemical Communications article Medicine Microbial Natural Products and Biosynthesis

Stefanie Brands, Jarno G. Sikkens, Mehdi D. Davari, Hannah U. C. Brass, Andreas Klein, Jörg Pietruszka, +2 more

15

citations
Dimerization of human PARP15 is required for NAD + binding and automodification
2026 FEBS Journal article Medicine PARP inhibition in cancer therapy Open access

0

citations
Protonation-dependent substrate release in a bacterial homolog of vesicular glutamate
2026 Biophysical Journal article Medicine Drug Transport and Resistance Mechanisms Open access

Natalia Dmitrieva, Samira Gholami, Mercedes Alfonso‐Prieto, Sanket A. Deshmukh, Davide Mandelli, Paolo Carloni, +1 more

0

citations
A screening method for binding synthetic metallo-complexes to haem proteins
2022 Analytical Biochemistry article Medicine Metal complexes synthesis and properties Open access

Laura V. Opdam, Ehider A. Polanco, Boyd de Regt, Nicole Lambertina, Cas Bakker, Sylvestre A. Bonnet, +1 more

8

citations
ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost
2021 Cell Reports Medicine article Medicine Drug Transport and Resistance Mechanisms Open access

Mark C. de Gooijer, Elles Marleen Kemper, Levi C.M. Buil, Ceren H. Çitirikkaya, Tessa Buckle, Jos H. Beijnen, +1 more

63

citations
DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis
2021 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Tuberculosis Research and Epidemiology Open access

Melissa Dalcina Chengalroyen, Mandy K. Mason, Alessandro Borsellini, R. Tassoni, Garth L. Abrahams, Sasha L. Lynch, +10 more

2

citations
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase
2026 RSC Medicinal Chemistry article Medicine SARS-CoV-2 and COVID-19 Research Open access

Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Craig D. L. Smith, +21 more

2

citations
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase
2025 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine SARS-CoV-2 and COVID-19 Research Open access

Irene Georgiou, Colin Robinson, Sean N. O’Byrne, Alex Matsuda, Przemysław Grygier, Shamshad Ahmad, +17 more

1

citations
Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters
2024 The EMBO Journal article Medicine Drug Transport and Resistance Mechanisms Open access

Samira Gholami, Claudia Alleva, Paolo Carloni, Mercedes Alfonso‐Prieto, Christoph Fahlke

10

citations
Transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters
2024 bioRxiv (Cold Spring Harbor Laboratory) preprint Medicine Drug Transport and Resistance Mechanisms Open access

Nataliia Dmitrieva, Samira Gholami, Claudia Alleva, Paolo Carloni, Mercedes Alfonso‐Prieto, Christoph Fahlke

2

citations
Front Cover: Identification of ß‐Glucocerebrosidase Activators for Glucosylceramide hydrolysis (ChemMedChem 7/2024)
2024 ChemMedChem paratext Medicine Lysosomal Storage Disorders Research Open access

Monika‐Sarah E. D. Schulze, Diana Scholz, Eric Jnoff, Adrian Hall, Jonathan Melin, Zara A. Sands, +1 more

0

citations
plantiSMASH 2.0: Improvements to Detection, Annotation, and Prioritization of Plant Biosynthetic Gene Clusters
2026 Journal of Molecular Biology article Medicine Microbial Natural Products and Biosynthesis Open access

Elena Del Pup, Charlotte Owen, Hannah E. Augustijn, Arjan Draisma, Guy Polturak, Satria Ardhe Kautsar, +3 more

11

citations
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway
2020 ACS Chemical Biology article Medicine Microbial Natural Products and Biosynthesis Open access

Xiansha Xiao, Somayah S. Elsayed, Changsheng Wu, Helga U. van der Heul, Mikko Metsä‐Ketelä, Chao Du, +5 more

14

citations
Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex
2023 ACS Chemical Biology article Medicine PARP inhibition in cancer therapy Open access

Sven Wijngaarden, Chunsong Yang, Carlos Vela‐Rodríguez, L. Lehtiö, Herman S. Overkleeft, Bryce M. Paschal, +1 more

12

citations
Transferrin receptor 1 shedding by the pro-inflammatory iRhom–ADAM17 complex and ADAM10 regulates cellular iron uptake and ferroptosis
2026 Experimental & Molecular Medicine article Medicine Iron Metabolism and Disorders Open access

Katharina Schun, Cindy Rinkens, Daniel Mehling, Yan Yu, Sarah Knapp, Carolin Peschke, +8 more

1

citations
Human Prothrombin Variants with Modifications in the Active Site S4 Subpocket Demonstrate Resistance to Dabigatran
2021 Blood conference-abstract Medicine Blood Coagulation and Thrombosis Mechanisms

Viola J.F. Strijbis, Ka Lei Cheung, Tessa A. Rutten, Pieter H. Reitsma, Daniël Verhoef, Mettine H.A. Bos

2

citations
Editorial: Reviews in gastrointestinal and hepatic pharmacology: 2024
2026 Frontiers in Pharmacology editorial Medicine Drug Transport and Resistance Mechanisms Open access

Anna Maria Giudetti, Ralf Weiskirchen

0

citations
Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic
2023 Chemical Communications article Medicine Microbial Natural Products and Biosynthesis

Ned P. Buijs, Eilidh J. Matheson, Stephen Albert Cochrane, Nathaniel I. Martin

23

citations
Molecular Modeling of Protein–Peptide Complexes Mimicking Factor Xa–Prothrombin Using AlphaFold-Multimer and Molecular Dynamics Simulations for Functional Prediction
2026 Journal of Chemical Information and Modeling article Medicine Blood Coagulation and Thrombosis Mechanisms

Dejvid Veizaj, David Alonzo Poole III, Ka Lei Cheung, Jos V. Flier, Pieter H. Reitsma, Daniël Verhoef, +2 more

1

citations
Modifications of the Prothrombin Active Site S4 Subpocket Confer Resistance to Dabigatran
2025 Thrombosis and Haemostasis article Medicine Blood Coagulation and Thrombosis Mechanisms Open access

Viola J.F. Strijbis, Ka Lei Cheung, Dejvid Veizaj, Tessa A. Rutten, Boris Bruin, Pieter H. Reitsma, +2 more

1

citations
Identification and functional characterization of cyclin Y/CDK16 phosphorylation substrates, regulating cellular stress response mechanisms
2025 RWTH Publications (RWTH Aachen) dissertation Medicine Autophagy in Disease and Therapy Open access

Jan Amelang

0

citations
Evolutionary adaptation of the γ‐carboxyglutamic acid domain in blood coagulation factor X in the Serpentes suborder
2021 The FASEB Journal article Medicine Blood Coagulation and Thrombosis Mechanisms

Shuzhen Cheng, Géraldine Poénou, Mark Schreuder, Mettine H.A. Bos

0

citations
Structural and Mechanistic Characterization of the Flavin-Dependent Monooxygenase and Oxidase Involved in Sorbicillinoid Biosynthesis
2025 ACS Chemical Biology article Medicine Microbial Natural Products and Biosynthesis Open access

Gwen Tjallinks, Nicolò Angeleri, Quoc‐Thai Nguyen, Barbara Mannucci, Mark Arentshorst, Jaap Visser, +3 more

6

citations
Negatively charged phospholipids stimulate factor XI activation by thrombin
2020 Thrombosis Update article Medicine Blood Coagulation and Thrombosis Mechanisms Open access

Farida Omarova, Jan Rosing, Rogier M. Bertina, Elisabetta Castoldi

5

citations
Identification and characterization of nanobodies specific for the human ubiquitin–like ISG15 protein
2025 Journal of Biological Chemistry article Medicine Monoclonal and Polyclonal Antibodies Research Open access cited by 1 patent

Prachi Dabhade, Charlotte Wijne, William McKibben, Simeon D. Draganov, Hedib Alkoumi H Alrawili, Zhen-Yu Jim Sun, +8 more

3

citations