Tu-PHS-02 - Frequency Mixing Magnetic Detection for Viscosity Sensitive Biosensing Using Magnetic Nanoparticle Relaxation

Poster, pp. 568–569

Abstract

Frequency Mixing Magnetic Detection (FMMD) enables magnetic biosensing by probing the nonlinear dynamic response of magnetic nanoparticles (MNPs) under dual-frequency (f1, f2) excitation.Known Brownian-relaxation dominated MNPs BNF-Dextran 80 nm were studied in media with varying viscosities.The complex signal components at the mixing harmonics 𝑓 1 + 2 • 𝑓 2 and 𝑓 1 + 4 • 𝑓 2 were analyzed as a function of the low frequency excitation field, and the harmonic ratio 𝑅 = 𝐴 (𝑓 1 +2𝑓 2 ) /𝐴 (𝑓 1 +4𝑓 2 ) was evaluated as a sensitive metric.The measured ratios show a pronounced dependency on viscosity and field amplitude.The complex-plane trajectories additionally reveal viscosity-dependent changes in both amplitude and phase.These findings show that harmonic-ratio analysis in FMMD can provide environment-sensitive readout beyond conventional single-harmonic amplitude detection.The approach is therefore promising for viscosity-sensitive biosensing, where target binding or matrix changes modify the local hydrodynamic environment of the MNPs.

Authors 7

1. Ali Mohammad Pourshahidi

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing , Bioelectronics (IBI-3) , Forschungszentrum Jülich , 52425 Jülich , Germany,

2. I. Nasr Allah
3. Timur Bikulov

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing , Bioelectronics (IBI-3) , Forschungszentrum Jülich , 52425 Jülich , Germany,

4. Abdalhalim Abuawad

   Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing , Bioelectronics (IBI-3) , Forschungszentrum Jülich , 52425 Jülich , Germany,

5. H. -J. Krause Aachen Medical Engineering and Applied Mathematics

   FH Aachen · Forschungszentrum Jülich

   Affiliation as printed

   Institute of Biological Information Processing , Bioelectronics (IBI-3) , Forschungszentrum Jülich , 52425 Jülich , Germany,

   Medical Engineering and Applied Mathematics , FH Aachen University of Applied Sciences , 52428 Jülich , Germany

6. A. Gholivand

   University of Bonn

   Affiliation as printed

   Institute of Epileptology and Cognition Research , Sensory Dynamics and Behavior Lab , University of Bonn , Faculty of Medicine , 53127 Bonn ,

7. U. M. Engelmann Aachen Medical Engineering and Applied Mathematics

   FH Aachen

   Affiliation as printed

   Medical Engineering and Applied Mathematics , FH Aachen University of Applied Sciences , 52428 Jülich , Germany