Multimodal Imaging-guided Tissue Sampling Combined with Multiomics Profiling Informs on Spatial Molecular and Cellular Heterogeneity Linked to Distinct Imaging Features in Diffuse Gliomas

Brain and Spine, vol. 6, pp. 106737

Abstract

displacement of all brain areas in 96 patients with spontaneous intracranial hypotension who underwent surgical closure of a spinal CSF leak.Based on the pre-and postoperative displacement maps, we calculated the Jacobian determinant as a measure of local brain expansion and compression, and the von Mises equivalent strain as a measure of local distortion.Results: Across patients, brain structures demonstrated consistent predominantly upward-outward postoperative shift.Most major brain regions exhibited statistically significant movement, with the highest magnitude seen in the parietal lobes and the left lateral ventricle (> 0.7 mm, p < .0001).Ventricles and transverse sinuses showed relevant perioperative expansion and contraction, respectively.Apart from ventricles, high strain was shown in temporomesial structures and the ventromedial prefrontal cortex (Fig. 1).Conclusions: Surgical CSF leak closure in SIH is associated with consistent, quantifiable postoperative brain shifts on MRI.We demonstrate strain in brain regions of SIH patients usually affected by frontotemporal dementia, which could explain similar clinical presentation in severe cases of SIH.AI-assisted image analysis in SIH may provide valuable prognostic information in clinical practice, potentially aiding the assessment of surgical outcome.

Authors 16

1. Niklas Joern Tillmanns

   Heinrich Heine University Düsseldorf · University of Duisburg-Essen

   Affiliation as printed

   Department of Neurosurgery, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

   Department of Neurosurgery, University of Duisburg-Essen, Essen, Germany

2. David Pauck

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

3. Michael Sabel
   Affiliation as printed

   Brain Cancer Center, Beta Clinic Bonn, Bonn, Germany

4. Marion Rapp
   Affiliation as printed

   Brain Cancer Center, Beta Clinic Bonn, Bonn, Germany

5. Quinn Volz

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

6. Bastian Malzkorn

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

7. Jörg Felsberg

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

8. Marietta Wolter

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

9. Kerstin Kaulich

   Heinrich Heine University Düsseldorf

   Affiliation as printed

   Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

10. Weiss Daniel

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Department of Diagnostic and Interventional Radiology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

11. Karl‐Josef Langen Aachen Department of Nuclear Medicine

    Forschungszentrum Jülich · Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany

    Institute of Neuroscience and Medicine (INM-4), Research Center Juelich, Juelich, Germany

12. Bernd Turowski

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Department of Diagnostic and Interventional Radiology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

13. Judith Rösler

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Department of Neurosurgery, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

14. Katharina Faust

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Department of Neurosurgery, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

15. Guido Reifenberger

    Heinrich Heine University Düsseldorf

    Affiliation as printed

    Institute of Neuropathology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

16. Philipp Lohmann Aachen Department of Nuclear Medicine

    Forschungszentrum Jülich · Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany

    Institute of Neuroscience and Medicine (INM-4), Research Center Juelich, Juelich, Germany