From phenotypic screening to target and compound prioritization for autosomal dominant polycystic kidney disease

SLAS DISCOVERY, vol. 44, pp. 100338

Abstract

AR-linked hypothesis and identified Esaxerenone as a compound-specific phenotypic hit; both require mechanistic confirmation and evaluation in additional disease models.

Authors 9

1. David Alencar Araripe Aachen

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands; Department of Human Genetics, Postzone S-04-P, Leiden University Medical Centre (LUMC), P.O. Box 9600, 2300 RC Leiden, the Netherlands

2. Margarita Iljin
   Affiliation as printed

   Crown Bioscience, BioPartner Center, 2333 CH Leiden, the Netherlands

3. Hester Bange
   Affiliation as printed

   Crown Bioscience, BioPartner Center, 2333 CH Leiden, the Netherlands

4. Leo Price
   Affiliation as printed

   Crown Bioscience, BioPartner Center, 2333 CH Leiden, the Netherlands

5. Rongfang Liu Aachen Division of Medicinal Chemistry Leiden Academic Centre for Drug Research

   Leiden University

   Affiliation as printed

   Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands

6. Daan van der Es Aachen Division of Medicinal Chemistry Leiden Academic Centre for Drug Research

   Leiden University

   Affiliation as printed

   Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands

7. Laura H. Heitman Aachen

   Leiden University · Oncode Institute

   Affiliation as printed

   Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands; Oncode Institute, Leiden the Netherlands

8. Dorien J.M. Peters Aachen Department of Human Genetics

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Human Genetics, Postzone S-04-P, Leiden University Medical Centre (LUMC), P.O. Box 9600, 2300 RC Leiden, the Netherlands. Electronic address: d.j.m.peters@lumc.nl

9. Gerard J. P. van Westen Aachen Division of Medicinal Chemistry Leiden Academic Centre for Drug Research

   Leiden University

   Affiliation as printed

   Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands. Electronic address: gerard@gjpvanwesten.nl