White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia

Neuroimage Reports, vol. 6, pp. 100405

Abstract

Introduction: Up to 30% of amnestic mild cognitive impairment (aMCI) subjects exhibit motor dysfunction. However, the relationship between white matter microstructural connectivity (SC) and motor function across the Alzheimer's disease (AD) spectrum remains unclear. This study investigated 1) white matter microstructural differences among cognitively unimpaired (CU) individuals, those with aMCI, and those with mild AD; and 2) associations between white matter microstructure and motor performance. Methods: Participants (CU = 68, aMCI = 44, AD = 34) underwent diffusion- and T1-weighted MRI. Whole-brain SC was assessed using weighted streamline count from probabilistic tractography between regions of the Brainnetome atlas. A subset (n = 103) also completed motor assessments (finger tapping, grip strength, spiral tracing, sequence learning). Group differences and AFD-motor associations were evaluated using threshold-free network-based statistics, corrected for multiple comparisons. Results: Compared with CU participants, those with AD exhibited reduced SC in 268 connections, predominantly involving the temporal lobe, thalamus, and hippocampus. Compared with aMCI, AD participants showed reduced SC in three connections linking frontal, parietal, and temporal regions. No significant SC differences were observed between CU and aMCI, and SC was not associated with motor performance. Conclusion: White matter SC is affected in AD, particularly in medial temporal lobe regions that are known to be affected early in the disease. Absence of differences between CU and aMCI, and small differences between aMCI and AD suggests that SC changes appear later in the disease course. The lack of SC-motor associations could reflect lack of variation in motor behavior in the sample.

Authors 7

1. Sarah E. Cote

   Yeshiva University · University of Utah

   Affiliation as printed

   Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA

   Department of Psychology, Yeshiva University, Ferkauf Graduate School of Psychology, Bronx, NY, USA

2. Marit F. L. Ruitenberg Aachen Department of Health, Medical, and Neuropsychology Leiden Institute for Brain and Cognition

   Leiden University

   Affiliation as printed

   Department of Health, Medical and Neuropsychology, Leiden University, Leiden, the Netherlands

   Leiden Institute for Brain and Cognition, Leiden, the Netherlands

3. Jos N. van der Geest

   Erasmus MC

   Affiliation as printed

   Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands

4. Nicholas Alonzo Frost

   University of Utah

   Affiliation as printed

   Department of Neurology, University of Utah, Salt Lake City, UT, USA

5. Jace B. King

   University of Utah

   Affiliation as printed

   Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA

   Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA

6. Kevin M. Duff

   Oregon Health & Science University · University of Utah

   Affiliation as printed

   Department of Neurology, University of Utah, Salt Lake City, UT, USA

   Oregon Alzheimer's Disease Research Center, Department of Neurology, Oregon Health & Science University, Portland, OR, USA

7. Vincent Koppelmans corresponding

   University of Utah

   Affiliation as printed

   Department of Psychiatry, University of Utah, Salt Lake City, UT, USA

   Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT, USA