A tablet-based attentional cognitive bias modification intervention for positive emotion processing in major depressive disorder: a single-blind randomised controlled two-centre trial
EBioMedicine, vol. 132, pp. 106453
Abstract
BACKGROUND: Patients with Major Depressive Disorder (MDD) exhibit biased information processing. This study investigates the clinical and neural efficacy of a cognitive bias modification (CBM) training in patients and healthy control (HCS), fostering processing of positive emotion stimuli. METHODS: In a single-blind randomised controlled trial (DRKS00029756), MDD outpatients and HCS, aged 18-60 years, were randomised to positivity training (PT) or control training (CT). Randomisation was carried out by study assistants, blinding researchers. Participants underwent 10 tablet-based dot-probe sessions over 14 days. PT implicitly redirected attention toward positive stimuli to improve depressive symptoms. Primary outcome was pre and post-training EEG-derived Early Posterior Negativity (EPN), investigating neural sensitivity towards positive stimuli. Secondary clinical outcomes included changes in depression symptoms. FINDINGS: = 0.049. The between-treatment difference was 1.65 μV, 95% CI [0.19, 3.11]. EPN amplitudes shifted towards negativity in PT and positivity in CT. Depression symptom decreased from pre to post and from pre to follow-up. With respect to adverse events, one patient in the control training was regularly admitted to hospital. INTERPRETATION: CBM positivity training was associated with neural changes in MDD, supporting its potential to target pre-attentive positive emotion processing. Further EEG follow-up and higher stimulus contrasts in the training conditions may clarify clinical relevance. FUNDING: Funded by DFG (ID: 507720021).
Authors 7
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University of Wuppertal · Essen University Hospital · University of Duisburg-Essen
Affiliation as printed
LVR-University Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Virchowstraße 174, Essen, 45147, Germany; Department of Psychology, University of Wuppertal, Gaußstraße 20, Wuppertal, 42119, Germany; Hospital of Duisburg-Essen, Centre for Translational Neuro and Behavioural Sciences (C-TNBS), Medical Faculty University, Hufelandstraße 55, Essen, 45147, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany
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Essen University Hospital · University of Duisburg-Essen
Affiliation as printed
LVR-University Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Virchowstraße 174, Essen, 45147, Germany; Hospital of Duisburg-Essen, Centre for Translational Neuro and Behavioural Sciences (C-TNBS), Medical Faculty University, Hufelandstraße 55, Essen, 45147, Germany
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University of Wuppertal · Essen University Hospital · University of Duisburg-Essen
Affiliation as printed
LVR-University Hospital Essen, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Duisburg-Essen, Virchowstraße 174, Essen, 45147, Germany; Department of Psychology, University of Wuppertal, Gaußstraße 20, Wuppertal, 42119, Germany; Hospital of Duisburg-Essen, Centre for Translational Neuro and Behavioural Sciences (C-TNBS), Medical Faculty University, Hufelandstraße 55, Essen, 45147, Germany
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Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstraße 30, Aachen, 52074, Germany; German Centre for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Philosophenweg 3, Jena, 07742, Germany. Electronic address: tfrodl@ukaachen.de
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