Populationsbasierte und metabolomische Auswertung der Morbidität und Mortalität bei Reizdarmpatienten

RWTH Publications (RWTH Aachen)

Abstract

Background: The Irritable bowel syndrome (IBS) is one of the most common functional digestive disorders. However, its pathophysiology is not yet fully understood, which complicates both diagnosis and therapy. Methods: I analyzed data of the UK Biobank (UKB), which includes around 500.000participants, among them 7656 ICD-10 coded and 20.603 self-reported IBS diagnoses. In order to characterize the disease more precisely, PheWAS analyses, competing risk regressions and metabolic evaluations were performed, each also stratified by gender. Results: In ICD-10-coded IBS patients (ICD-10-IBS), PheWAS analyses revealed 553overrepresented PheCodes, compared to 247 in self-reported IBS patients. In addition to gastrointestinal diseases, musculoskeletal, psychiatric, respiratory and metabolic diseases were common. Overall mortality was increased in ICD-10-IBS patients(HR=1.3 [95% CI, 1.2–1.4]), which was also confirmed in the gender-specific analysis for both men and women. Furthermore, ICD-10-IBS was associated with higher mortality rates from respiratory (HR=2.1 [95% CI, 1.6–2.7]), musculoskeletal (HR=3.8[95% CI, 2.0–7.3]) and cancer-related (HR=1.2 [95% CI, 1.1–1.4]) causes. An increased overall or cancer-related mortality could not be replicated in patients with self-reported IBS. In fact, the risk of dying from cancer was even reduced in this group(HR=0.8 [95% CI, 0.7-0.9]). Analyses of serum metabolites showed that higher levels of Glycoprotein Acetyls (GlycA) were associated with an increased risk of IBS diagnosis as well as an increased mortality risk in ICD-10-IBS patients. Conclusion: IBS is associated with specific comorbidities and an increased risk of cause-specific mortality. In addition, GlycA was identified as a potential biomarker. The results suggest that IBS has organ-specific effects on individual health.

Authors 1

1. Katharina Sophie Seeling corresponding Aachen

   RWTH Aachen University

   Affiliation as printed

   RWTH Aachen