Circulating succinate changes during acute cold exposure are not related with brown adipose tissue in humans
Journal of Physiology and Biochemistry, vol. 82
Abstract
Abstract Brown adipose tissue (BAT) activity in humans is linked to better glucose metabolism and cardiometabolic health. In mice, cold exposure increases circulating succinate and enhances BAT thermogenesis, but whether similar succinate responses occur in humans remains undetermined. We analysed data from 33 young (18–25 years), sedentary adults (20 women) from the ACTIBATE cohort (NCT02365129). Plasma succinate was measured enzymatically at baseline and 60 and 120 min during a personalized cooling protocol. BAT volume, activity, and radiodensity were assessed via static 18 F-fluorodeoxyglucose positron emission tomography–computed tomography ( 18 F-FDG PET-CT) at the end of the cold exposure. Circulating succinate changed over time during cold exposure, with no significant change at 60 min and a significant increase at 120 min versus baseline (+ 23.8%, P = 0.017), with substantial interindividual variability. Exploratory stratification by median baseline succinate revealed divergent temporal patterns: the low-baseline group showed increases at 60 min (+ 46%) and 120 min (+ 80.5%; both P ≤ 0.021), while the high-baseline group showed reductions at both timepoints (–31.4% and − 2.4%; both P ≤ 0.003). These profiles were not explained by phenotypic or BAT-related parameters. In the full cohort, changes in circulating succinate were not associated with BAT outcomes. Overall, our findings indicate that circulating succinate responses during acute cold exposure are highly heterogeneous and no associated with BAT PET/CT-derived parameters in humans.
Authors 8
-
Instituto de Salud Carlos III · Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · Institut de Recerca Biomèdica Catalunya Sud
Affiliation as printed
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain
DIAMET Research Group, Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud), Tarragona, Spain
-
Borja Martínez‐Téllez Aachen Department of Medicine Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine
Leiden University Medical Center · Instituto de Salud Carlos III · Complejo Hospitalario Torrecárdenas · University of Almería
Affiliation as printed
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, 04009, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, 18012, Spain
Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing, Physiotherapy and Medicine and SPORT Research Group, CIBIS Research Center, University of Almería, Almería, 04120, Spain
-
Universidad de Granada · Instituto de Salud Carlos III · Instituto de Investigación Biosanitaria de Granada
Affiliation as printed
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, 18012, Spain
Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Andalucía, Spain
Instituto de Investigación Biosanitaria (Ibs), Granada, 18014, Spain
-
University of Turku · Turku University Hospital · Turku PET Centre
Affiliation as printed
InFLAMES Research Flagship Center, University of Turku, Turku, Finland
MediCity Research Laboratories, University of Turku, Turku, Finland
Turku PET Centre, Turku University Hospital, Turku, Finland
Turku PET Centre, University of Turku, Turku, Finland
-
Universidad de Granada · Instituto de Salud Carlos III
Affiliation as printed
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, 18012, Spain
Department of Physiology, Faculty of Medicine, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Andalucía, Spain
-
Instituto de Salud Carlos III · Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · Institut de Recerca Biomèdica Catalunya Sud · Universitat Rovira i Virgili
Affiliation as printed
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain
DIAMET Research Group, Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud), Tarragona, Spain
Universitat Rovira i Virgili (URV), Reus, 43201, Spain
-
Jonatan R. Ruiz corresponding
Universidad de Granada · Instituto de Salud Carlos III · Instituto de Investigación Biosanitaria de Granada
Affiliation as printed
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, 18012, Spain. ruizj@ugr.es
Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health, University Research Institute (iMUDS), University of Granada, Crta Alfcar s/n. 18011, Granada, 18071, Spain. ruizj@ugr.es
Instituto de Investigación Biosanitaria (Ibs), Granada, 18014, Spain. ruizj@ugr.es
-
Sonia Fernández‐Veledo corresponding
Instituto de Salud Carlos III · Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · Institut de Recerca Biomèdica Catalunya Sud · Universitat Rovira i Virgili
Affiliation as printed
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. sonia.fernandezveledo@gmail.com
DIAMET Research Group, Institut de Recerca Biomèdica Catalunya Sud (IRB CatSud), Tarragona, Spain. sonia.fernandezveledo@gmail.com
Universitat Rovira i Virgili (URV), Reus, 43201, Spain. sonia.fernandezveledo@gmail.com
Cited by 0 stored of 0
No patents citing this paper on Lens.org (checked 2026-10-11).