Cardiac photon-counting detector computed tomography in acute ischemic stroke: diagnostic accuracy for detection of left atrial appendage thrombus

Therapeutic Advances in Neurological Disorders, vol. 19, pp. 17562864261466073

Abstract

Background: In up to one-third of ischemic stroke patients, no cause can be identified. Left atrial appendage (LAA) is the primary anatomical origin of cardiac embolism, yet it is often inadequately assessed in stroke etiological workup. Objectives: The goal of this study was to analyze the diagnostic accuracy of cardiac photon-counting detector computed tomography (PCD-CT) integrated in the acute stroke imaging protocol for detection of LAA thrombus. Design: Retrospective diagnostic accuracy study. Methods: We selected consecutive patients with acute ischemic stroke or transient ischemic attack undergoing emergent cardiac PCD-CT and transesophageal echocardiography (TEE) between 2023 and 2025. Cardiac PCD-CT and TEE were assessed for the detection of LAA thrombus. Patients with and without LAA thrombus (defined by PCD-CT) were compared. Diagnostic performance metrics for cardiac PCD-CT for LAA thrombus detection were calculated using TEE as the gold standard. Results: We included 101 patients, 42 were female (42%), median age was 59 years, 87 patients had acute ischemic stroke (86%). Median time between cardiac PCD-CT and TEE was 2 days. LAA thrombus defined by PCD-CT was present in 12 patients (12%). Patients with LAA thrombus were older (74 vs 58 years, p < 0.001) and more frequently had atrial fibrillation (83.3% vs 23.6%, p < 0.001). Diagnostic accuracy of PCD-CT was 96% (95% confidence interval (95%CI) = 90%–99%), sensitivity was 90% (95%CI = 56–100), specificity was 97% (95%CI = 91%–99%), positive predictive value was 75% (95%CI = 49%–90%), and negative predictive value was 99% (95%CI = 93%–100%). Conclusion: Cardiac PCD-CT integrated as part of the acute stroke imaging protocol is a promising diagnostic tool that may reliably exclude the presence of LAA thrombus.

Authors 12

1. Annemarie Kirschfink Aachen Department of Internal Medicine I (Cardiology)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Internal Medicine I (Cardiology), University Hospital RWTH Aachen, Aachen, Germany

2. Mohamed Elhalal Aachen Department of Diagnostic and Interventional Neuroradiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany

3. Stefanie Kammer Aachen Department of Neurology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany

4. Dimah Hasan Aachen Department of Diagnostic and Interventional Neuroradiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany

5. Michael Frick Aachen Department of Internal Medicine I (Cardiology)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Internal Medicine I (Cardiology), University Hospital RWTH Aachen, Aachen, Germany

6. Nikolaus Marx Aachen Department of Internal Medicine I (Cardiology)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Internal Medicine I (Cardiology), University Hospital RWTH Aachen, Aachen, Germany

7. Jörg B. Schulz Aachen Department of Neurology JARA-BRAIN Institute for Molecular Neuroscience and Neuroimaging

   Forschungszentrum Jülich · Universitätsklinikum Aachen · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany

   JARA-BRAIN Institute for Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and Medical Faculty, RWTH Aachen University, Aachen, Germany

8. Martin Wiesmann Aachen Department of Diagnostic and Interventional Neuroradiology

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany

9. Ertunc Altiok Aachen Department of Internal Medicine I (Cardiology)

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Internal Medicine I (Cardiology), University Hospital RWTH Aachen, Aachen, Germany

10. Hani Ridwan Aachen Department of Diagnostic and Interventional Neuroradiology

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Diagnostic and Interventional Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany

11. Arno Reich Aachen Department of Neurology

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany

12. João Pinho corresponding Aachen Department of Neurology

    Universitätsklinikum Aachen · RWTH Aachen University

    Affiliation as printed

    Department of Neurology, University Hospital RWTH Aachen, Pauwelsstr. 30, Aachen 52074, Germany