Treatment satisfaction during personalized extended interval dosing of natalizumab in patients with multiple sclerosis
Multiple Sclerosis and Related Disorders, vol. 113, pp. 107409
Abstract
BACKGROUND: Extended interval dosing (EID) of natalizumab is increasingly used in clinical practice for patients with multiple sclerosis, driven by growing evidence supporting its sustained efficacy and associated benefits. However, it remains unclear whether EID, particularly at dosing intervals beyond six weeks, affects treatment satisfaction. OBJECTIVES: To investigate whether natalizumab dosing intervals of up to ten weeks are associated with patient-reported treatment satisfaction. METHODS: Participants from the prospective NEXT-MS and SUPERNEXT trials, both evaluating concentration-guided EID while preserving therapeutic drug concentrations, completed longitudinal Treatment Satisfaction Questionnaire for Medication (TSQM) assessments. Associations between dosing interval and scores in the four TSQM domains (Effectiveness, Side effects, Convenience, and Overall satisfaction) were analyzed using linear mixed-effects models. RESULTS: A total of 427 participants were included. Most participants reported high treatment satisfaction. No overall association was observed between dosing interval and TSQM scores. However, additional effect-modification analyses suggested that the association between dosing interval and treatment satisfaction differed according to treatment duration, disease duration, baseline EDSS, and route of natalizumab administration. CONCLUSIONS: Treatment satisfaction was high and was not affected by longer dosing intervals in the majority of patients. However, additional effect-modification analyses indicated that the impact of dosing interval on treatment satisfaction may differ according to patient characteristics, highlighting the importance of individualized treatment decisions.
Authors 31
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Liza M. Y. Gelissen corresponding
Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands. Electronic address: l.m.y.gelissen@amsterdamumc.nl
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
Department of Rehabilitation Medicine, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands
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Elisabeth-TweeSteden Ziekenhuis
Affiliation as printed
Department of Neurology, Elizabeth Tweesteden Hospital, Tilburg, the Netherlands
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Department of Neurology, Medical Center Leeuwarden, Leeuwarden, the Netherlands
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Department of Neurology, Diakonessenhuis Hospital, Utrecht, the Netherlands
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Department of Neurology, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands
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Department of Neurology, Spaarne Gasthuis, Haarlem, the Netherlands
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Department of Neurology, Ziekenhuisgroep Twente, Almelo, the Netherlands
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Department of Neurology, Isala, Meppel, the Netherlands
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Department of Neurology, MS center Alrijne Hospital, Leiden, the Netherlands
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Department of Neurology, St Antonius Hospital, Utrecht, the Netherlands
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Department of Neurology, OLVG, Amsterdam, the Netherlands
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Department of Neurology, Wilhelmina Hospital, Assen, the Netherlands
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Department of Neurology, Reinier de Graaf Hospital, Delft, the Netherlands
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Department of Neurology, Rijnstate Hospital, Arnhem, the Netherlands
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Department of Neurology, Amphia, Breda, the Netherlands
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Ommelander Ziekenhuis Groningen
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Department of Neurology, Ommelander Hospital, Scheemda, the Netherlands
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Department of Neurology, Maasstad Hospital, Rotterdam, the Netherlands
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Department of Neurology, Slingeland Hospital, Doetinchem, the Netherlands
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Department of Neurology, Flevoziekenhuis, Almere, the Netherlands
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Department of Neurology, ErasMS, Erasmus Medical Center, Rotterdam, the Netherlands
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Department of Neurology, Maasstad Hospital, Rotterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam Public Health · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Quality of Care, Amsterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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Amsterdam University Medical Centers
Affiliation as printed
Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, the Netherlands
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Sanquin · Amsterdam institute for Immunology and Infectious Diseases · Amsterdam UMC Location Vrije Universiteit Amsterdam
Affiliation as printed
Department of Immunopathology, Sanquin Research Amsterdam, Amsterdam, the Netherlands; Molecular Cell Biology and Immunology, Amsterdam UMC, location Vrije Universiteit Amsterdam, De Boelelaan, Amsterdam, the Netherlands; Amsterdam institute for Immunology and Infectious diseases, Immunology, Amsterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · Vrije Universiteit Amsterdam
Affiliation as printed
MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location Boelelaan, Amsterdam, the Netherlands
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