July 13, 2026 review Open access Design, simulate, refine: simulation-guided clinical trials for accelerated drug development Nature Reviews Drug Discovery DOI: 10.1038/s41573-026-01481-9 Full text (OA) OpenAlex Authors 0 Author list not loaded yet. Cited by 0 stored of 0 References 4 Search Sort Most cited Newest Oldest Patent citations Title Any typearticle review book-chapter conference-paper preprint dissertation book dataset other Any fieldAgricultural and Biological Sciences Arts and Humanities Biochemistry, Genetics and Molecular Biology Business, Management and Accounting Chemical Engineering Chemistry Computer Science Decision Sciences Dentistry Earth and Planetary Sciences Economics, Econometrics and Finance Energy Engineering Environmental Science Health Professions Immunology and Microbiology Materials Science Mathematics Medicine Neuroscience Nursing Pharmacology, Toxicology and Pharmaceutics Physics and Astronomy Psychology Social Sciences Veterinary Open access Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL 2023 EClinicalMedicine article Mathematics Statistical Methods in Clinical Trials Open access 48 citations ChatGPT as a Tool for Biostatisticians: A Tutorial on Applications, Opportunities, and Limitations 2025 Statistics in Medicine article Medicine Artificial Intelligence in Healthcare and Education Open access 17 citations Regulatory Issues of Platform Trials: Learnings from EU‐PEARL 2024 Clinical Pharmacology & Therapeutics article Mathematics Statistical Methods in Clinical Trials Open access 17 citations A Pharmacometrics‐Informed Trial Simulation Framework for Optimizing Study Designs for Disease‐Modifying Treatments in Rare Neurological Disorders 2025 CPT Pharmacometrics & Systems Pharmacology article Mathematics Statistical Methods in Clinical Trials Open access 3 citations 4 results