Tissue-embedded CD4+ plasticity defines mucosal immunity in inflammatory bowel disease

Mucosal Immunology, vol. 19, pp. 100369

Abstract

memory subset retained multifunctionality, producing elevated levels of pro-inflammatory cytokines. Together, these results define a dynamic, tissue-embedded CD4 T-cell landscape in IBD.

Authors 13

1. Qinyue Jiang Aachen Department of Immunology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands

2. Veerle A. Merkus Aachen Department of Dermatology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands

3. Ciska Lindelauf Aachen Department of Immunology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands

4. Jens Krijgsman Aachen Department of Immunology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands

5. Nannan Guo

   Zhujiang Hospital · Southern Medical University

   Affiliation as printed

   Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

6. Laura F. Ouboter Aachen

   Leiden University Medical Center

   Affiliation as printed

   Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands

7. Thomas Höllt

   Delft University of Technology

   Affiliation as printed

   Computer Graphics and Visualization, Delft University of Technology, Delft, the Netherlands

8. Philip W. Voorneveld Aachen Department of Gastroenterology and Hepatology

   Leiden University Medical Center

   Affiliation as printed

   Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands

9. Caroline R. Meijer-Boekel Aachen Department of Pediatrics, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands

10. Frits Koning Aachen Department of Immunology, Leiden University Medical Center

    Leiden University Medical Center

    Affiliation as printed

    Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands

11. Andrea E. van der Meulen‐de Jong Aachen Department of Gastroenterology and Hepatology

    Leiden University Medical Center

    Affiliation as printed

    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands

12. María Fernanda Pascutti

    Amsterdam University Medical Centers

    Affiliation as printed

    Immunotherapy Center Amsterdam UMC, Amsterdam University Medical Center, Amsterdam, the Netherlands

13. Vincent van Unen Aachen Department of Immunology, Leiden University Medical Center

    Leiden University Medical Center

    Affiliation as printed

    Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: v.van_unen@lumc.nl