An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2
Brain Behavior & Immunity - Health, vol. 54, pp. 101267
Abstract
= 0.850 in HAP. Furthermore, the models achieved high predictive performance across all individual PROMIS domain scores in both samples. We provide an externally validated methodology for accurately predicting mental and physical symptomatology following hospitalization due to a severe viral infection. This approach may facilitate the development of a brief risk stratification tool at the point of hospitalization, enabling early identification of at-risk patients, improving the prediction accuracy of subsequent psychological and physical sequelae, and supporting timely preventive interventions.
Authors 34
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Katharina Schultebraucks corresponding
Affiliation as printed
Department of Psychiatry, NYU Grossman School of Medicine, New York, USA
Division of Healthcare Delivery Science, Department of Population Health, NYU Grossman School of Medicine, New York, USA
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Affiliation as printed
Department of Psychiatry, NYU Grossman School of Medicine, New York, USA
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin · Freie Universität Berlin · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany
German Center for Mental Health, Partner Site Berlin/Potsdam, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany
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Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Affiliation as printed
Clinical Trial Unit of the Clinical Study Center (CSC), Berlin Institute of Health (BIH), Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany
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Affiliation as printed
Department of Psychiatry, University Hospital Würzburg, Germany
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University Hospital Frankfurt · Goethe University Frankfurt
Affiliation as printed
Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany
Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany
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Affiliation as printed
Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany
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University of Cologne · University Hospital Cologne
Affiliation as printed
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany
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Affiliation as printed
Institute for Digital Medicine and Clinical Data Science, Faculty of Medicine, Goethe University Frankfurt, Germany
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Affiliation as printed
Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany
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Affiliation as printed
Institute for Clinical Epidemiology and Biometry, University Hospital Würzburg, Germany
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Universitätsmedizin Greifswald · Universität Greifswald
Affiliation as printed
Klinische Chemie und Laboratoriumsmedizin, University Medicine Greifswald, Germany
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Affiliation as printed
Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany
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Universitätsmedizin Göttingen · University of Göttingen
Affiliation as printed
Emergency Department, University Medical Center Göttingen, Germany
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Affiliation as printed
Institute for Digital Medicine, University of Augsburg, Germany
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Bielefeld University · Klinikum Bielefeld
Affiliation as printed
Department of Cardiology, Universitäty Medical Center Bielefeld, Germany
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Universitätsmedizin Greifswald · Universität Greifswald
Affiliation as printed
Department of Orthopaedics, Trauma and Rehabilitation Medicine, Universitätsmedizin Greifswald, Germany
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University Medical Center Hamburg-Eppendorf
Affiliation as printed
Infection Research and Vaccine Development, University Medical Center Hamburg-Eppendorf, Germany
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Edgar Dahl Aachen
Affiliation as printed
RWTH Centralized Biomaterial Bank (RWTH CBMB) at the Institute of Pathology, RWTH Aachen University, Germany
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Essen University Hospital · Stiftung Universitätsmedizin Essen
Affiliation as printed
Institute of Infectiology, University Medical Center Essen, Germany
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University Hospital Regensburg
Affiliation as printed
Department for Infectious Diseases and Infection Control, University Hospital Regensburg, Germany
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Technical University of Munich · TUM Klinikum
Affiliation as printed
Department of Psychosomatic Medicine and Psychotherapy, Klinikum rechts der Isar, Technichal University of Munich, Germany
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Otto-von-Guericke-Universität Magdeburg
Affiliation as printed
Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Otto von Guericke University Magdeburg, Germany
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University Hospital Frankfurt · Goethe University Frankfurt
Affiliation as printed
Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany
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University of Cologne · Helmholtz Munich · University Hospital Cologne · University Hospital Frankfurt · Goethe University Frankfurt
Affiliation as printed
Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany
Institute of Epidemiology, Research Unit Molecular Epidemiology, Helmholtz Munich, Germany
University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Infectious Diseases, Cologne, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Experimental and Clinical Research Center (ECRC), Charité - Universitätsmedizin Berlin, Germany
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Charité - Universitätsmedizin Berlin · German Center for Lung Research
Affiliation as printed
Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité - Universitätsmedizin Berlin, Germany
German Center for Lung Research (DZL), Partner Site Berlin, Germany
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin · Freie Universität Berlin · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin, Medizinische Klinik Mit Schwerpunkt für Psychosomatik, Center for Patient-Centered Outcomes Research, Germany
German Center for Mental Health, Partner Site Berlin/Potsdam, Germany
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Charité - Universitätsmedizin Berlin · Deutsches Zentrum für Psychische Gesundheit
Affiliation as printed
Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin, Germany
German Center for Mental Health, Partner Site Berlin/Potsdam, Germany
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