Spatial immune profiling characterizes tumor microenvironment heterogeneity between metastatic and nonmetastatic cutaneous squamous cell carcinoma in organ transplant patients

Journal of Investigative Dermatology, vol. 146, pp. 2924–2928.e10

Abstract

Solid organ transplant recipients (sOTRs) face an up to 100-fold increased risk of developing cutaneous squamous cell carcinoma (cSCC) compared to immunocompetent individuals (de Jong et al., 2024). These cancers not only occur more frequently in sOTRs, but also tend to present more aggressively, with increased risk of recurrence, perineural invasion, and metastasis (Genders et al., 2019). Although classic histopathological risk factors apply to both groups, the mechanisms underlying the elevated metastatic risk in sOTRs remain poorly understood.

Authors 10

1. Veerle A. Merkus corresponding Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address: v.a.merkus@lumc.nl

2. M. Ijsselsteijn Aachen Department of Pathology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands

3. Estella de Jong Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

4. Cornelis P. Tensen Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

5. A. El Ghalbzouri Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

6. Ferenc A. Scheeren Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

7. Maarten H. Vermeer Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

8. Noel F.C.C. de Miranda Aachen Department of Pathology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands

9. Jan Nico Bouwes Bavinck Aachen Department of Dermatology, Leiden University Medical Centre

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands

10. K. D. Quint Aachen Department of Dermatology, Leiden University Medical Centre

    Leiden University · Leiden University Medical Center

    Affiliation as printed

    Department of Dermatology, Leiden University Medical Centre, Leiden, the Netherlands