Consensus on acromegaly complications: an update
Pituitary, vol. 29
Abstract
The 16th Acromegaly Consensus Conference in September 2024 updated recommendations on diagnosis and treatment of acromegaly comorbidities. Since the 2020 acromegaly comorbidity management guideline was published, new evidence has emerged on novel and known comorbidities and new treatment approaches. Forty-three experts in the management of acromegaly reviewed the current literature and assessed changes in clinical practice standards and management. Current outcome goals were considered and updated, with a focus on the impact of current and emerging treatments of these comorbidities. Participants assessed factors that determine pharmacological choices, as well as use of specific agents in the management of the most relevant acromegaly comorbidities. We present consensus recommendations highlighting optimization of evidence-based acromegaly comorbidities management.
Authors 43
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Vita-Salute San Raffaele University · IRCCS Ospedale San Raffaele
Affiliation as printed
Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Milan, Italy
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Vita-Salute San Raffaele University · IRCCS Ospedale San Raffaele
Affiliation as printed
Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Milan, Italy
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Oregon Health & Science University
Affiliation as printed
Pituitary Center, Medicine and Neurological Surgery, Oregon Health & Science University, Portland, OR, USA
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University of Naples Federico II
Affiliation as printed
Università Federico II di Napoli, Naples, Italy
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Affiliation as printed
ENDOC Center for Endocrine Tumors, Hamburg, Germany
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University of Oxford · Oxford Centre for Diabetes, Endocrinology and Metabolism · Oxford University Hospitals NHS Trust
Affiliation as printed
Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals, Oxford, UK
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Affiliation as printed
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Jacksonville, FL, USA
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Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC, Department of Endocrinology and Metabolism, University of Amsterdam, Pituitary Center Amsterdam, Amsterdam, Netherlands
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Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · Instituto Maimónides de Investigación Biomédica de Córdoba · University of Córdoba
Affiliation as printed
Department of Cell Biology, Physiology, and Immunology, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), University of Cordoba, Cordoba, Spain
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Vall d'Hebron Hospital Universitari
Affiliation as printed
Endocrinology & Nutrition Department, Hospital Universitario Vall de Hebrón, Barcelona, Spain
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Affiliation as printed
Department of Medical Sciences, Section of Endocrinology, Geriatrics & Internal Medicine, University of Ferrara, Ferrara, Italy
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Garvan Institute of Medical Research · UNSW Sydney
Affiliation as printed
Garvan Institute of Medical Research, St. Vincent's Hospital and the UNSW Sydney, Sydney, Australia
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Universidade Federal do Paraná
Affiliation as printed
Department of Internal Medicine, Endocrine Division (SEMPR), University Hospital, Federal University of Parana, Curitiba, Brazil
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Affiliation as printed
Pituitary Center Rotterdam, Erasmus University Medical Center, Rotterdam, Netherlands
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University of Cambridge · Wellcome/MRC Institute of Metabolic Science · Addenbrooke's Hospital
Affiliation as printed
Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
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Nienke Ruurdje Biermasz Aachen Division of Endocrinology Department of Medicine Center for Endocrine Tumors Leiden
Leiden University · Leiden University Medical Center
Affiliation as printed
Division of Endocrinology, Department of Medicine, Center for Endocrine Tumors Leiden, Leiden University Medical Center, Leiden, The Netherlands
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LMU Klinikum · Ludwig-Maximilians-Universität München · Deggendorf Institute of Technology
Affiliation as printed
Medizinische Klinik und Poliklinik IV, LMU Klinikum, LMU Munich, Germany & Deggendorf Institute of Technology, Deggendorf, Germany
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Ospedale Policlinico San Martino · University of Genoa
Affiliation as printed
Endocrinology Unit, IRCCS Ospedale Policlinico San Martino, Università di Genova, Genova, Italy
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Universidade Federal do Rio de Janeiro
Affiliation as printed
Neuroendocrinology Research Center/Endocrinology Division, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Affiliation as printed
Department of Medicine, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
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Affiliation as printed
Department of Medical Sciences, University of Turin, Turin, Italy
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Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Endocrinology and Metabolism, Charité- Universitätsmedizin Berlin, Berlin, Germany
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Istanbul University-Cerrahpaşa · Istanbul University
Affiliation as printed
Division of Endocrinology-Metabolism and Diabetes, Istanbul University - Cerrahpasa, Istanbul, Türkiye, Turkey
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Affiliation as printed
Department of Medicine, Padua University, Padua, Italy
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Affiliation as printed
Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK
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Hospital Universitario de La Princesa · Universidad Autónoma de Madrid
Affiliation as printed
Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Madrid, Spain
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Affiliation as printed
Department of Neurosurgery, University Hospital Erlangen, 91054, Erlangen, Germany
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Agostino Gemelli University Polyclinic · Istituti di Ricovero e Cura a Carattere Scientifico
Affiliation as printed
UOC Endocrinology and Diabetology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
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Affiliation as printed
Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria
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Tel Aviv University · Tel Aviv Sourasky Medical Center
Affiliation as printed
Institute of Endocrinology, Diabetes, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Tel Aviv University, Tel Aviv-Yafo, Israel
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Universitat Internacional de Catalunya · Centre for Biomedical Network Research on Rare Diseases · Hospital Universitari Germans Trias i Pujol
Affiliation as printed
Endocrinology Department, Germans Trias i Pujol Hospital and Research Institute, CIBERER Unit 747, Universitat Internacional de Catalunya, Barcelona, Spain
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Complejo Hospitalario Universitario de Santiago
Affiliation as printed
Endocrinology & Nutrition Department, Hospital Universitario de Santiago de Compostela, Santiago de Compostela, Spain
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IRCCS Istituto Auxologico Italiano · Link Campus University
Affiliation as printed
Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy
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Inserm · Université Paris-Saclay · Assistance Publique – Hôpitaux de Paris · Bicêtre Hospital · Physiologie et Physiopathlogie Endocriniennes
Affiliation as printed
Physiologie et Physiopathologie Endocriniennes, Reference Center for Rare Pituitary Diseases (CRMR HYPO), Université Paris-Saclay, Inserm, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin- Bicêtre, France
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Inserm · Aix-Marseille Université · Assistance Publique Hôpitaux de Marseille · Hôpital de la Conception
Affiliation as printed
AP-HM, Aix Marseille Univ, INSERM, MMG, MarMaRa, Marseille, France; Reference Center for Rare Pituitary Diseases (CRMR HYPO), La Conception University Hospital, Marseille, France
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University Hospitals Birmingham NHS Foundation Trust
Affiliation as printed
University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
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Complejo Hospitalario Universitario de Santiago · Instituto de Investigación Sanitaria de Santiago
Affiliation as printed
Santiago de Compostela University, IDIS-Complejo Hospitalario Universitario de Santiago (CHUS), CIBERobn, Instituto Salud Carlos III, Santiago de Compostela, Spain
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Federico II University Hospital · University of Naples Federico II
Affiliation as printed
Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy
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Vita-Salute San Raffaele University · IRCCS Ospedale San Raffaele
Affiliation as printed
Department of Neurosurgery and Gamma Knife Radiosurgery, Università Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan, Italy
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Affiliation as printed
Department of Medicine, Section Endocrinology, Erasmus MC, Rotterdam, Netherlands
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Hospital Universitari Germans Trias i Pujol
Affiliation as printed
Department of Endocrinology & Nutrition, Germans Trias i Pujol University Hospital, Badalona, Spain and CIBER-ER, ISCIII, Badalona, Spain
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Vita-Salute San Raffaele University · Recep Tayyip Erdoğan University · IRCCS Ospedale San Raffaele
Affiliation as printed
Department of Endocrinology and Metabolism Disease, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey
Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Milan, Italy
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Shlomo K. Melmed corresponding
Affiliation as printed
Cedars-Sinai Medical Center, Los Angeles, CA, USA. melmed@csmc.edu
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