Human stem cell-based embryo models: innovation, ethics, and policy.
Apollo (University of Cambridge)
Abstract
Acknowledgements: We are grateful to the Institute Pasteur for hosting the meeting that led to this paper and Doug Sipp for contributions to the initial discussions and the kickoff meeting that informed the early development of this manuscript.
Authors 44
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Institució Catalana de Recerca i Estudis Avançats · Universitat Pompeu Fabra
Affiliation as printed
Instituci� o Catalana de Recerca i Estudis Avanc¸ats (ICREA) and MELIS Universitat Pompeu Fabra , Barcelona , Spain
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Institute of Molecular Biotechnology
Affiliation as printed
Institute of Molecular Biotechnology of the
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Centre National de la Recherche Scientifique · Institut Pasteur · Biologie du Développement et Cellules Souches
Affiliation as printed
Department of Developmental and Stem Cell Biology , Stem Cells and Development Unit , Institut Pasteur , Universit� e Paris Cit� e , CNRS UMW 3738 , Paris , France
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Affiliation as printed
Institute for the Advanced Study of Human Biology (ASHBi) , Kyoto University , Kyoto , Japan
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Centre National de la Recherche Scientifique · Institut Pasteur · Biologie du Développement et Cellules Souches
Affiliation as printed
Institut Pasteur , Universit� e Paris Cit� e , CNRS UMR3738 , Zebrafish Neurogenetics Unit , Paris , France
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University of Zurich · University Hospital Zurich
Affiliation as printed
Department of Reproductive Endocrinology , University Hospital Zurich , University of Zurich , Zurich , Switzerland
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Affiliation as printed
Durham Law School , Durham University , Durham , UK
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Affiliation as printed
Institute for the Advanced Study of Human Biology (ASHBi) , Kyoto University , Kyoto , Japan
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BGI Group (China) · University of Tabuk
Affiliation as printed
3DC STAR Lab , BGI CELL , Shenzhen , China
Prince Fahad bin Sultan Research Chair for Biomedical Research , University of Tabuk , Tabuk , Saudi Arabia
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Affiliation as printed
Department of Biomedical Engineering , University of Michigan , Ann Arbor , MI , USA
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Leiden University Medical Center · Novo Nordisk Foundation Center for Stem Cell Medicine
Affiliation as printed
Department of Anatomy and Embryology , Leiden University Medical Center , Leiden , The Netherlands
The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) , Leiden Node , Leiden , The Netherlands
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Leiden University Medical Center · Novo Nordisk Foundation Center for Stem Cell Medicine
Affiliation as printed
Department of Medical Ethics & Health Law , Leiden University Medical Center , Leiden , The Netherlands
The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) , Leiden Node , Leiden , The Netherlands
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Affiliation as printed
Department of Molecular Genetics , Weizmann Institute of Science , Rehovot , Israel
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Affiliation as printed
Department of History and Philosophy of Science , University of Cambridge , Cambridge , UK
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Jawaharlal Nehru Centre for Advanced Scientific Research · Institute for Stem Cell Biology and Regenerative Medicine
Affiliation as printed
Centre for Research Application and Training in Embryology (CReATE) , Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem) , Bangalore , India
Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) , Bangalore , India
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Karolinska University Hospital · Karolinska Institutet
Affiliation as printed
Department of Gynecology and Reproductive Medicine , Karolinska University Hospital , Stockholm , Sweden
Division of Obstetrics and Gynecology , Department of Clinical Science, Intervention and Technology , Karolinska Institutet , Karolinska Universitetssjukhuset , Stockholm , Sweden
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University of Zurich · University Hospital Zurich
Affiliation as printed
Department of Reproductive Endocrinology , University Hospital Zurich , University of Zurich , Zurich , Switzerland
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Affiliation as printed
Primate lab Institute of Neuroscience , CAS , Shanghai , China
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Affiliation as printed
The Francis Crick Institute , London , UK
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The University of Melbourne · Murdoch Children's Research Institute
Affiliation as printed
Department of Paediatrics , University of Melbourne , Parkville , VIC , Australia
Stem Cell Ethics & Policy Group , Murdoch Children's Research Institute , Parkville , VIC , Australia
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University of Cambridge · The Loke Centre for Trophoblast Research
Affiliation as printed
Loke Centre for Trophoblast Research , Department of Physiology, Development and Neuroscience , University of Cambridge , Cambridge , UK
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Brigham and Women's Hospital · Harvard University
Affiliation as printed
Department of Genetics , Harvard Medical School , Boston , MA , USA
Department of Pathology , Brigham and Women's Hospital , Boston , MA , USA
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Affiliation as printed
Department of Development and Regeneration , Leuven Institute for Single Cell Omics (LISCO) , KU Leuven , Leuven , Belgium
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Harvard University · University of Toronto · Chinese Academy of Sciences · University of Cambridge · Hospital for Sick Children · Jackson Laboratory · Institute of Zoology · State Key Laboratory of Stem Cell and Reproductive Biology
Affiliation as printed
The Jackson Laboratory , Mammalian Genetics, Bar Harbor, ME, USA 35 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China 36 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China 37 Centre de Recherche du Centre Hospitalier, Universit� e de Montr� eal, Montr� eal, Canada 38 D� epartement de M� edecine, Molecular Biology Programme, Universit� e de Montr� eal, Montr� eal, Canada 39 Departments of Molecular and Cellular Biology, Stem Cell and Regenerative Biology, Applied Physics, Harvard University, Cambridge, MA,USA 40 Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA 41 The Gairdner Foundation and the Hospital for Sick Children, University of Toronto, Toronto, Canada 42 Babraham Institute (UK) Epigenetics Programme, Babraham Institute, Cambridge, UK 43 Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK 44 Department of Anatomy and Cell B
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Affiliation as printed
Institute for the Advanced Study of Human Biology (ASHBi) , Kyoto University , Kyoto , Japan
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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Institute of Molecular Biotechnology · Austrian Academy of Sciences · Vienna Biocenter
Affiliation as printed
Austrian Academy of Sciences (IMBA) , Vienna BioCenter (VBC) , Vienna , Austria
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The University of Texas at Austin
Affiliation as printed
Department of Molecular Biosciences , University of Texas at Austin , Austin , TX , USA
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Cincinnati Children's Hospital Medical Center
Affiliation as printed
Division of Developmental Biology , Center for Stem Cell & Organoid Medicine (CuSTOM) , Cincinnati Children's Hospital , Cincinnati , OH , USA