Translational fluorescence lifetime imaging using exogenous probes

Abstract

Oncologic surgery can greatly benefit from imaging techniques for the accurate identification of tumor-positive margins both intraoperatively and in resection specimens immediately following surgery. We have demonstrated clinically that fluorescence lifetime can significantly improve the accuracy for tumor vs. normal classification compared to fluorescence intensity in multiple cancer types using tumor targeted agents. We will present recent progress towards the translation of lifetime imaging for improving tumor contrast in multiple types of solid tumors. We will also discuss novel high speed lifetime imaging techniques and their application for intraoperative imaging in patients injected with the FDA approved dye, Indocyanine green.

Authors 21

1. Anand T. N. Kumar

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

2. Murali Krishnamoorthy

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

3. Rahul Pal

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

4. Katherine T. Frazee

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

5. Shriya Shukla

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

6. Brigitta J. Sticker Aachen Leiden Univ. Medical Ctr

   Leiden University Medical Center

   Affiliation as printed

   Leiden Univ. Medical Ctr. (Netherlands)

7. Tom H. Dijkhuis
8. Corey. Chan

   Newcastle University

   Affiliation as printed

   Newcastle Univ. (United Kingdom)

9. Peter M. Sadow

   Massachusetts Eye and Ear Infirmary

   Affiliation as printed

   Massachusetts Eye and Ear (United States)

10. William C. Faquin

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

11. Yin Pun Hung

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

12. Kenneth Samora Rankin

    Newcastle University

    Affiliation as printed

    Newcastle Univ. (United Kingdom)

13. Alexander L. Vahrmeijer Aachen Leiden Univ. Medical Ctr

    Leiden University Medical Center

    Affiliation as printed

    Leiden Univ. Medical Ctr. (Netherlands)

14. J. Sven D. Mieog Aachen Leiden Univ. Medical Ctr

    Leiden University Medical Center

    Affiliation as printed

    Leiden Univ. Medical Ctr. (Netherlands)

15. Thinzar Min Lwin

    City Of Hope National Medical Center · City of Hope

    Affiliation as printed

    City of Hope (United States)

16. Kenneth Tanabe

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

17. Santiago A. Lozano‐Calderón

    Massachusetts General Hospital

    Affiliation as printed

    Massachusetts General Hospital (United States)

18. Jeremy Richmon

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

19. Kevin Emerick

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

20. Allen L. Feng

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)

21. Mark Alex Varvares

    Massachusetts Eye and Ear Infirmary

    Affiliation as printed

    Massachusetts Eye and Ear (United States)