Lessons learned on how to reengineer enzymes for improved performance in ionic liquids: insights from BSLA saturation mutagenesis library
Green Chemistry, vol. 28, pp. 4705–4714
Abstract
Based on a complete BSLA saturation mutagenesis library, this review shows how ionic liquids reshape enzyme solvation and performance. Preserving and modulating the hydration shell emerges as a key design principle for IL-tolerant biocatalysts.
Authors 5
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RWTH Aachen University · Beijing University of Chemical Technology
Affiliation as printed
Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany
State Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Lab of Bioprocess, College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
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RWTH Aachen University · Beijing University of Chemical Technology
Affiliation as printed
Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany
State Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Lab of Bioprocess, College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
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Chinese Academy of Sciences · Tianjin Institute of Industrial Biotechnology
Affiliation as printed
State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin 300308, PR China
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Leilei Zhu corresponding
Chinese Academy of Sciences · Tianjin Institute of Industrial Biotechnology
Affiliation as printed
State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, 32 West 7th Avenue, Tianjin 300308, PR China
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RWTH Aachen University · Beijing University of Chemical Technology
Affiliation as printed
Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany
State Key Laboratory of Green Biomanufacturing, National Energy R&D Center for Biorefinery, Beijing Key Lab of Bioprocess, College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
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