A Prospective Multicenter Observational Study Investigating the Concordance Between Patient-Reported Hearing Loss and Commonly Used Ototoxicity Grading Systems in Patients Treated with Platinum-Based Chemotherapy
Annals of Otology Rhinology & Laryngology, vol. 135, pp. 443–452
Abstract
Purpose: This study aims to compare the accuracy of the TUNE, American Speech-Language-Hearing Association (ASHA), and Common Terminology Criteria for Adverse Events (CTCAE) grading systems in reflecting the severity of treatment-related hearing loss, as measured by pure-tone audiometry and patient-reported hearing loss using the Speech, Spatial, and Qualities of Hearing scale compare questionnaire (SSQ). Methods: This study is a prospective, multicenter, cross-sectional, and observational study from 2018 to 2024 conducted at the Netherlands Cancer Institute - Antoni van Leeuwenhoek Amsterdam, Leiden University Medical Center, and University Medical Center Utrecht. In this trial, 109 patients with an indication for curative platinum-based chemotherapy (dose ≥ 200 mg/m 2 ) were included, of whom 74 were eligible for analysis. Standard frequency and extended high-frequency pure tone audiometry were measured at baseline and follow-up. The SSQ was administered at follow-up to assess patient-reported outcome measures for hearing loss. The TUNE, ASHA, and CTCAE criteria were derived from audiometry. Concordance and Spearman’s correlations were evaluated between all 3 grading systems and the SSQ. Results: The concordance of TUNE with the SSQ was 81%. The concordance of CTCAE and ASHA with the SSQ was 73% and 68%, respectively. A statistically significant Spearman’s correlation coefficient of −.35 ( P = .01) was found between TUNE and the SSQ. The Spearman’s correlation coefficient with CTCAE or ASHA and SSQ was −.10 ( P = .10) and .04 ( P = .75), respectively. Conclusion: This study found that the TUNE is better in reflecting platinum-related patient-reported hearing loss compared to the CTCAE and ASHA.
Authors 18
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Leiden University · Leiden University Medical Center · The Netherlands Cancer Institute
Affiliation as printed
Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands
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Leiden University · Leiden University Medical Center · Medisch Centrum Haaglanden · Stichting Haaglanden Medisch Centrum
Affiliation as printed
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands
Department of Otolaryngology, Haaglanden Medical Center, The Hague, The Netherlands
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Affiliation as printed
Department of Otolaryngology, Reinier de Graaf Hospital, Delft, The Netherlands
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University Medical Center Utrecht
Affiliation as printed
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands
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Medizinische Hochschule Brandenburg Theodor Fontane
Affiliation as printed
Institute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany
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University Medical Center Utrecht
Affiliation as printed
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Medical Oncology, Leiden University Medical Center, Leiden University, The Netherlands
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University Medical Center Utrecht
Affiliation as printed
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands
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University Medical Center Utrecht
Affiliation as printed
Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Utrecht, UMC Brain Centre, The Netherlands
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University Medical Center Utrecht
Affiliation as printed
Department of Medical Oncology, University Medical Center Utrecht, The Netherlands
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Amsterdam UMC Location University of Amsterdam · Amsterdam University Medical Centers
Affiliation as printed
Department of Audiology, Amsterdam University Medical Center, The Netherlands
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Leiden University · Leiden University Medical Center · Gelre Hospitals
Affiliation as printed
Apeldoorn Dizziness Centre, Gelre Hospital Apeldoorn, The Netherlands
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands
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The Netherlands Cancer Institute
Affiliation as printed
Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
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Leiden University · Leiden University Medical Center · The Netherlands Cancer Institute
Affiliation as printed
Department of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Otolaryngology and Head and Neck Surgery, Leiden University Medical Center, Leiden University, The Netherlands
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