AnySleep: a channel-agnostic deep learning system for high-resolution sleep staging in multi-center cohorts

PubMed

Abstract

Sleep is essential for good health throughout our lives, yet studying its dynamics requires manual sleep staging, a labor-intensive step in sleep research and clinical care. Across centers, polysomnography (PSG) recordings are traditionally scored in 30-s epochs for pragmatic, not physiological, reasons and can vary considerably in electrode count, montage, and subject characteristics. These constraints present challenges in conducting harmonized multi-center sleep studies and discovering novel, robust biomarkers on shorter timescales. Here, we present AnySleep, a deep neural network model that uses any electroencephalography (EEG) or electrooculography (EOG) data to score sleep at adjustable temporal resolutions. We trained and validated the model on over 19,000 overnight recordings from 21 datasets collected across multiple clinics, spanning nearly 200,000 hours of EEG and EOG data, to promote robust generalization across sites. The model attains state-of-the-art performance and surpasses or equals established baselines at 30-s epochs. Performance improves as more channels are provided, yet remains strong when EOG is absent or when only EOG or single EEG derivations (frontal, central, or occipital) are available. On sub-30-s timescales, the model captures short wake intrusions consistent with arousals and improves prediction of physiological characteristics (age, sex) and pathophysiological conditions (sleep apnea), relative to standard 30-s scoring. We make the model publicly available to facilitate large-scale studies with heterogeneous electrode setups and to accelerate the discovery of novel biomarkers in sleep.

Authors 4

1. Niklas Grieger
2. Jannik Raskob Aachen Department of Medical Engineering and Technomathematics Institute for Data-Driven Technologies

   FH Aachen

   Affiliation as printed

   Department of Medical Engineering and Technomathematics , FH Aachen University of Applied Sciences , 52428 Jülich , Germany,

   Institute for Data-Driven Technologies , FH Aachen University of Applied Sciences , 52428 Jülich , Germany

3. Siamak Mehrkanoon

   Utrecht University

   Affiliation as printed

   Department of Information and Computing Sciences , Utrecht University , Utrecht , The Netherlands,

4. Stephan Bialonski Aachen Department of Medical Engineering and Technomathematics Institute for Data-Driven Technologies

   FH Aachen

   Affiliation as printed

   Department of Medical Engineering and Technomathematics , FH Aachen University of Applied Sciences , 52428 Jülich , Germany,

   Institute for Data-Driven Technologies , FH Aachen University of Applied Sciences , 52428 Jülich , Germany