The BrainPET-7T Insert for Neuroscientific Applications: Performance with and without MRI
Abstract
We present the performance of a high-resolution, high-sensitivity, and UHF-MRI-compatible BrainPET insert for in vivo multimodal and multi-parametric neuroscientific imaging applications in humans. In this performance evaluation we studied mutual compatibility, PET-relevant imaging parameters, (spatial resolution, sensitivity, noise equivalent count rate, and coincidence time resolution), and MRI-relevant imaging parameters, (image homogeneity, image SNR, field homogeneity, and quality of spectra acquired for single-voxel${ }^{1} \mathrm{H}$spectroscopy). Potential imaging applications for nuclei other than${ }^{1} \mathrm{H}$(e.g.${ }^{13} \mathrm{C},{ }^{19} ~\mathrm{F},{ }^{23} \text{Na}$, and${ }^{31} \mathrm{P}$) were also considered. In addition, we acquired PET-only in ovo images of a chick embryo and compared the images to those obtained with a Siemens Inveon small animal PET/CT. The PET insert was shown to have a homogeneous spatial resolution of$\approx 1.6 ~\text{mm}$paired with a sensitivity of$57.2 \text{kcps} / \text{MBq}$. MR image SNR is$\approx 10 \%$lower when measured with the PET insert installed and running. However, spurious RF noise spectra with running PET are free of detectable interference for${ }^{1} \mathrm{H}$and${ }^{19} ~\mathrm{F}$within the relevant frequency bandwidths. No PET count rate loss was observed for most typical MR sequences. Thus, the BrainPET-7T provides a unique multimodal imaging tool for neuroscience with excellent MR and PET image quality.
Authors 27
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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LuK Lamellen und Kupplungsbau (Germany)
Affiliation as printed
Affinity Imaging GmbH,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Integrated Computing Architectures - Peter Grünberg Institute 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Integrated Computing Architectures - Peter Grünberg Institute 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Integrated Computing Architectures - Peter Grünberg Institute 4,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Affiliation as printed
Hyperion Hybrid Imaging Systems GmbH,Aachen,Germany
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Florian Mueller Aachen Physics of Molecular Imaging System/Institute of Experimental Molecular Imaging
Affiliation as printed
Rheinisch-Westfälische Technische Hochschule, Physics of Molecular Imaging System/Institute of Experimental Molecular Imaging,Aachen,Germany
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Affiliation as printed
Hyperion Hybrid Imaging Systems GmbH,Aachen,Germany
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Affiliation as printed
Hyperion Hybrid Imaging Systems GmbH,Aachen,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Technology and Engineering,Jülich,Germany
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Pierre Gebhardt Aachen Physics of Molecular Imaging System/Institute of Experimental Molecular Imaging
Affiliation as printed
Rheinisch-Westfälische Technische Hochschule, Physics of Molecular Imaging System/Institute of Experimental Molecular Imaging,Aachen,Germany
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Affiliation as printed
Inviscan Imaging Systems SA,Strasbourg,France
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Affiliation as printed
Monash University, Monash Biomedical Imaging,Monash,Australia
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Affiliation as printed
Monash University, Monash Biomedical Imaging,Monash,Australia
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Affiliation as printed
Rheinisch-Westfälische Technische Hochschule, Institute of Imaging & Computer Vision,Aachen,Germany
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Affiliation as printed
Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine 4,Jülich,Germany
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