White Matter Bundle Reconstruction From Single‐Shell Diffusion Magnetic Resonance Imaging: Test–Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods
Human Brain Mapping, vol. 46, pp. e70429
Abstract
Deriving white matter (WM) bundles in vivo has thus far mainly been applied in research settings, leveraging high angular resolution, multi-shell diffusion MRI (dMRI) acquisitions that enable modern reconstruction methods. However, these advanced acquisitions are both time-consuming and costly to acquire. The ability to reconstruct WM bundles in the massive amounts of existing single-shelled, lower angular resolution data from legacy research studies and healthcare systems would offer much broader clinical applications and population-level generalizability. While legacy scans may offer a valuable, large-scale complement to contemporary research datasets, the reliability of white matter bundles derived from these scans remains unclear. Here, we leverage a large research dataset where each 64-direction dMRI scan was acquired as two independent 32-direction runs per subject. To investigate how a state-of-the-art bundle-specific reconstruction method generalizes to this data, we evaluated the test-retest reliability of WM bundles reconstructed from the two 32-direction scans across three orientation distribution function (ODF) reconstruction methods: generalized q-sampling imaging (GQI), constrained spherical deconvolution (CSD), and single-shell three-tissue CSD (SS3T). We found that the majority of WM bundles could be reliably extracted from dMRI scans that were acquired using the 32-direction, single-shell acquisition scheme. The mean Dice coefficient of reconstructed WM bundles was consistently higher within subject than between subject for all WM bundles and ODF reconstruction methods, illustrating preservation of person-specific anatomy. Further, when using features of the bundles to predict complex reasoning assessed using a computerized cognitive battery, we observed stable prediction accuracies (r: 0.15-0.36) across the test-retest data. Among the three ODF reconstruction methods, SS3T had a good balance between sensitivity and specificity when comparing the reconstructed bundles to atlas bundles, a high intra-class correlation of extracted features, more plausible bundles, and strong predictive performance. More broadly, these results demonstrate that bundle-specific reconstruction can achieve robust performance even on lower angular resolution, single-shell dMRI, with particular advantages for ODF methods optimized for single-shell data. This highlights the considerable potential for dMRI collected in healthcare settings and legacy research datasets to accelerate and expand the scope of WM research.
Authors 19
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Amelie Rauland Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Faculty of Medicine
Forschungszentrum Jülich · RWTH Aachen University
Affiliation as printed
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine RWTH Aachen University Aachen Germany
Institute of Neuroscience and Medicine, Brain and Behaviour (INM‐7) Research Center Jülich Jülich Germany
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Child and Adolescent Psychiatry and Behavioral Science The Children's Hospital of Philadelphia Philadelphia Pennsylvania USA
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Semma Therapeutics (United States) · University of Pennsylvania
Affiliation as printed
Department of Psychiatry, Brain Behavior Laboratory, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA
Sama Therapeutics Cambridge Massachusetts USA
Department of Psychiatry, Brain Behavior Laboratory, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Sama Therapeutics, Cambridge, Massachusetts, USA
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Forschungszentrum Jülich · Düsseldorf University Hospital · Heinrich Heine University Düsseldorf
Affiliation as printed
Institute of Neuroscience and Medicine, Brain and Behaviour (INM‐7) Research Center Jülich Jülich Germany
Institute of Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf Heinrich Heine University Düsseldorf Düsseldorf Germany
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Affiliation as printed
Section for Translational Neurodegeneration, Department of Neurology RWTH Aachen University Aachen Germany
Section for Translational Neurodegeneration, Department of Neurology, RWTH Aachen University, Aachen, Germany
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Affiliation as printed
Center for AI and Data Science for Integrated Diagnostics (AI2D), University of Pennsylvania Philadelphia Pennsylvania USA
Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA
Center for AI and Data Science for Integrated Diagnostics (AI2D), University of Pennsylvania, Philadelphia, Pennsylvania, USA
Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Department of Radiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA
Division of Neuroradiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA
Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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University of Pittsburgh · University of Pittsburgh Medical Center
Affiliation as printed
Department of Psychiatry University of Pittsburgh Medical Center, University of Pittsburgh Pittsburgh Pennsylvania USA
Department of Psychiatry, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Children's Hospital of Philadelphia · University of Pennsylvania
Affiliation as printed
Department of Radiology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania USA
Division of Neuroradiology Children's Hospital of Philadelphia Philadelphia Pennsylvania USA
Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Division of Neuroradiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Forschungszentrum Jülich · Düsseldorf University Hospital · Heinrich Heine University Düsseldorf
Affiliation as printed
Institute of Neuroscience and Medicine, Brain and Behaviour (INM‐7) Research Center Jülich Jülich Germany
Institute of Systems Neuroscience, Medical Faculty and University Hospital Düsseldorf Heinrich Heine University Düsseldorf Düsseldorf Germany
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Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Theodore Daniel Satterthwaite corresponding
Children's Hospital of Philadelphia · University of Pennsylvania Health System · University of Pennsylvania
Affiliation as printed
Department of Psychiatry University of Pennsylvania Philadelphia Pennsylvania USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania Philadelphia Pennsylvania USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania Philadelphia Pennsylvania USA
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP, University of Pennsylvania, Philadelphia, Pennsylvania, USA
The Penn Lifespan Informatics and Neuroimaging Center (PennLINC), University of Pennsylvania, Philadelphia, Pennsylvania, USA
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