State-dependent brain responsiveness, from local circuits to the whole brain

eLife

Abstract

The objective of this paper is to review physiological and computational aspects of the responsiveness of the cerebral cortex to stimulation, and how responsiveness depends on the state of the system. This correspondence between brain state and brain responsiveness (statedependent responses) is outlined at different scales from the cellular and circuit level, to the mesoscale and macroscale level. At each scale, we review how quantitative methods can be used to characterize network states based on brain responses, such as the Perturbational Complexity Index (PCI). This description will compare data and models, systematically and at multiple scales, with a focus on the mechanisms that explain how brain responses depend on brain states.

Authors 34

1. Alain Destexhe

   Centre National de la Recherche Scientifique · Université Paris-Saclay · Institut des Neurosciences Paris-Saclay

   Affiliation as printed

   Paris-Saclay University, Institute of Neuroscience (NeuroPSI), CNRS

2. Jennifer S. Goldman

   Centre National de la Recherche Scientifique · Université Paris-Saclay · Institut des Neurosciences Paris-Saclay

   Affiliation as printed

   Paris-Saclay University, Institute of Neuroscience (NeuroPSI), CNRS

3. Núria Tort‐Colet

   Centre National de la Recherche Scientifique · Université Paris-Saclay · Institut des Neurosciences Paris-Saclay

   Affiliation as printed

   Paris-Saclay University, Institute of Neuroscience (NeuroPSI), CNRS

4. Axel Roques

   Centre National de la Recherche Scientifique · Université Paris-Saclay · Institut des Neurosciences Paris-Saclay

   Affiliation as printed

   Paris-Saclay University, Institute of Neuroscience (NeuroPSI), CNRS

5. Jan Fousek

   Aix-Marseille Université

   Affiliation as printed

   Aix-Marseille University

6. Spase Petkoski

   Aix-Marseille Université

   Affiliation as printed

   Aix-Marseille University

7. Viktor Jirsa

   Aix-Marseille Université

   Affiliation as printed

   Aix-Marseille University

8. Olivier David

   Aix-Marseille Université

   Affiliation as printed

   Aix-Marseille University

9. Maciej Jedynak

   Aix-Marseille Université

   Affiliation as printed

   Aix-Marseille University

10. Cristiano Capone

    Istituto Nazionale di Fisica Nucleare

    Affiliation as printed

    INFN

11. Chiara MG De Luca

    Istituto Nazionale di Fisica Nucleare

    Affiliation as printed

    INFN

12. G. De Bonis

    Istituto Nazionale di Fisica Nucleare

    Affiliation as printed

    INFN

13. Pier Stanislao Paolucci

    Istituto Nazionale di Fisica Nucleare

    Affiliation as printed

    INFN

14. Ezequiel Mikulan
    Affiliation as printed

    UMIL

15. Andrea Pigorini
    Affiliation as printed

    UMIL

16. Marcello Massimini
    Affiliation as printed

    UMIL

17. Andrea Galluzzi
    Affiliation as printed

    ISS

18. Antonio Pazienti
    Affiliation as printed

    ISS

19. Maurizio Mattia
    Affiliation as printed

    ISS

20. Alessandro Arena

    University of Oslo

    Affiliation as printed

    UiO

21. Bjørn Erik Juel

    University of Oslo

    Affiliation as printed

    UiO

22. Espen Hagen

    University of Oslo

    Affiliation as printed

    UiO

23. Johan Frederik Storm

    University of Oslo

    Affiliation as printed

    UiO

24. Elena Montagni
    Affiliation as printed

    LENS

25. Francesco Saverio Pavone
    Affiliation as printed

    LENS

26. Anna Letizia Allegra Mascaro
    Affiliation as printed

    LENS

27. Abhilash Dwarakanath corresponding

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Affiliation as printed

    CEA, NeuroSpin

28. Theofanis I. Panagiotaropoulos

    Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Affiliation as printed

    CEA, NeuroSpin

29. Johanna Senk

    University of Sussex · Forschungszentrum Jülich

    Affiliation as printed

    Institute for Advanced Simulation (IAS-6), Jülich Research Centre

    Sussex AI, School of Engineering and Informatics, University of Sussex

30. Markus Diesmann Aachen Department of Psychiatry, Psychotherapy and Psychosomatics Department of Physics School of Medicine Faculty 1

    RWTH Aachen University · Forschungszentrum Jülich · Jülich Aachen Research Alliance

    Affiliation as printed

    Department of Physics, Faculty 1, RWTH Aachen University

    Department of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University

    Institute for Advanced Simulation (IAS-6), Jülich Research Centre

    JARA-Institute Brain Structure-Function Relationships (INM-10), Jülich Research Centre

31. Alessandra Camassa

    Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

    Affiliation as printed

    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

32. Leonardo Dalla Porta

    Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

    Affiliation as printed

    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

33. Arnau Manasanch

    Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

    Affiliation as printed

    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

34. Maria Victoria Sanchez-Vives

    Institució Catalana de Recerca i Estudis Avançats · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

    Affiliation as printed

    ICREA

    Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)