EndoCompass Project: Research Roadmap for Growth Disorders
Hormone Research in Paediatrics, vol. 98, pp. 1–14
Abstract
BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At the national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project - a joint initiative between the European Society of Endocrinology and the European Society of Pediatric Endocrinology - aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges. METHODS: Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in growth disorders was conducted to identify key research priorities, followed by broader stakeholder engagement, including society members and patient advocacy groups. RESULTS: Research priorities encompass genetic diagnosis of growth disorders, growth plate-targeted therapies, molecular mechanisms of Silver-Russell syndrome and imprinting disorders, hypothalamic dysfunction in Prader-Willi syndrome, and characterization of Noonan syndrome and tall stature conditions. Emphasis is placed on creating disease registries to facilitate outcome studies and developing precision therapeutics based on growth regulation pathways. CONCLUSIONS: This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into growth disorder pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.
Authors 21
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Queen Mary University of London · Barts Health NHS Trust · William Harvey Research Institute
Affiliation as printed
Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK, evelien.gevers@nhs.net
Department of Paediatric Endocrinology, Royal London Children's Hospital, Barts Health NHS Trust, London, UK, evelien.gevers@nhs.net
Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Department of Paediatric Endocrinology, Royal London Children's Hospital, Barts Health NHS Trust, London, UK
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Erasmus MC · Erasmus MC - Sophia Children’s Hospital
Affiliation as printed
Department of Paediatrics, Erasmus University Medical Centre Rotterdam, Sophia Children's Hospital, Rotterdam, The Netherlands
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Université Toulouse III - Paul Sabatier · Hôpital des Enfants
Affiliation as printed
Centre de Référence Maladies Rares PRADORT (syndrome de Prader-Willi et autres Obésités Rares avec Troubles du comportement alimentaire), Hôpital des Enfants, CHU Toulouse, Université Toulouse III, Toulouse, France
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University Children's Hospital Tübingen
Affiliation as printed
Pediatric Endocrinology, University Children's Hospital, Tubingen, Germany
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Queen Mary University of London · Blizard Institute
Affiliation as printed
Blizard Institute, Barts and The London Medical School, Queen Mary University of London, London, UK
Centre for Epigenetics, Queen Mary University of London, London, UK
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Inserm · Université de Lille · Centre Hospitalier Universitaire de Lille · Lille Neurosciences & Cognition
Affiliation as printed
FHU 1000 Days for Health, School of Medicine, Lille, France
Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, University of Lille, Inserm, CHU Lille, Lille, France
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Universitat Autònoma de Barcelona · Corporació Sanitària Parc Taulí · Institute of Research and Innovation Parc Tauli
Affiliation as printed
Endocrinology and Nutrition Department, Institut d'Investigació, Parc Taulí Hospital Universitari, Sabadell, Spain
Medicine Department, Universitat Autònoma de Barcelona, Sabadell, Spain
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Southampton Children's Hospital · University of Southampton
Affiliation as printed
Faculty of Medicine, University of Southampton, Southampton, UK
Regional Centre for Paediatric Endocrinology, Southampton Children's Hospital, Southampton, UK
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Children's National · George Washington University
Affiliation as printed
Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
Division of Endocrinology, Children's National Hospital, Washington, District of Columbia, USA
Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
Division of Endocrinology, Children's National Hospital, Washington, DC, USA
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Centre National de la Recherche Scientifique · Inserm · Centre Hospitalier Universitaire de Toulouse · RESTORE · Université de Toulouse
Affiliation as printed
Department of Endocrinology, Bone Diseases and Genetics, Reference Centre for Rare Diseases of Growth and Development, FIRENDO Network, Children's Hospital, University Hospital of Toulouse, Toulouse, France
RESTORE Research Centre, CNRS, INSERM, EFS, Université de Toulouse, Toulouse, France
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Affiliation as printed
Centre for Human Genetics and Genome Medicine, Medical Faculty, RWTH University Aachen, Aachen, Germany
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Sorbonne Université · Centre de Recherche Saint-Antoine
Affiliation as printed
Explorations Fonctionelles Endocriennes, Centre de Recherche Saint Antoine, APHP, Sorbonne Universite, Paris, France
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Sorbonne Université · Centre de Recherche Saint-Antoine
Affiliation as printed
Explorations Fonctionelles Endocriennes, Centre de Recherche Saint Antoine, APHP, Sorbonne Universite, Paris, France
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Karolinska University Hospital · Karolinska Institutet
Affiliation as printed
Division of Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden
Pediatric Endocrinology Unit and Center for Molecular Medicine, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden
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Univerzitetski Klinički Centar Srbije
Affiliation as printed
Clinic of Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Belgrade, Serbia
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Radboud University Nijmegen · Radboud University Medical Center · Amalia Kinderziekenhuis
Affiliation as printed
Department of Pediatrics, Division of Endocrinology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands
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Bambino Gesù Children's Hospital
Affiliation as printed
Molecular Genetics and Functional Genomics, Bambino Gesù Children's Hospital IRCCS, Rome, Italy
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St George’s University Hospitals NHS Foundation Trust · City St George's, University of London
Affiliation as printed
Department of Medicine, City St George's University of London, London, UK
South West Thames Regional Genomics Service, St George's University Hospitals NHS Foundation Trust, London, UK
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Affiliation as printed
Faculty of Medicine, University of Southampton, Southampton, UK
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Centre National de la Recherche Scientifique · Inserm · RESTORE · Université de Toulouse
Affiliation as printed
RESTORE Research Centre, CNRS, INSERM, EFS, Université de Toulouse, Toulouse, France
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University Hospital Magdeburg · Otto-von-Guericke-Universität Magdeburg
Affiliation as printed
Institute of Human Genetics, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, Germany
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