Peer Review Report For: ELIXIR and Toxicology: a community in development [version 1; peer review: 1 approved, 1 approved with reservations]
Abstract
Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.
Authors 60
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Marvin Martens corresponding
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Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, 6229 ER
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Netherlands Organisation for Applied Scientific Research
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Risk Analysis for Products In Development (RAPID), Netherlands Organisation for applied scientific research TNO, Utrecht, 3584 CB
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University of Luxembourg · Luxembourg Centre for Systems Biomedicine
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Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, 4367
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Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, 6229 ER
Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, 6229 EN
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National and Kapodistrian University of Athens
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Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, 15771
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Bulgarian Academy of Sciences · Institute of Biophysics and Biomedical Engineering
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Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, 1113
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Swiss Federal Institute of Aquatic Science and Technology
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Department Environmental Chemistry, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, 8600
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Université de Paris, Paris, F-75006
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RECETOX, Faculty of Science, Masaryk University, Brno
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Department of Physical Chemistry, Palacky University Olomouc, Olomouc, 77146
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Health Unit, Health, Mol, 2400
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RECETOX, Faculty of Science, Masaryk University, Brno
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National Institutes of Health · National Center for Biotechnology Information
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National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894
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Chemotargets SL, Barcelona, 08028
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National and Kapodistrian University of Athens
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Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, 15771
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School of Science, GSFC University, Gujarat, 391750
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Forschungs- und Beratungsinstitut Gefahrstoffe (FoBiG) GmbH, Freiburg im Breisgau, 79106
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Seven Past Nine, Cerknica, 1380
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AIMMS Division of Molecular Toxicology, Vrije Universiteit, Amsterdam, 1081 HZ
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Department of Toxicology, Misvik Biology, Turku, 20520
Institute of Environmental Medicine, Karolinska Institute, Stockholm, 17177
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Department of Computer Science, Heriot-Watt University, Edinburgh
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ELIXIR Hub, Wellcome Genome Campus, Cambridge, CB10 1SD
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Department Evolutionary Ecology & Environmental Toxicology (E3T), Goethe-University, Frankfurt, D-60438
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Ideaconsult Ltd., Sofia
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Department of Toxicogenomics, Maastricht University, Maastricht, 6200 MD
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Toxicologie Alimentaire · MetaboHUB · Université de Toulouse
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MetaboHUB, French metabolomics infrastructure in Metabolomics and Fluxomics, Toulouse
Toxalim (Research Centre in Food Toxicology), Université de Toulouse, Toulouse
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Scientific Network Management SL, Barcelona, 08015
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RECETOX, Faculty of Science, Masaryk University, Brno
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Department of Toxicogenomics, Maastricht University, Maastricht, 6200 MD
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University of Luxembourg · Luxembourg Centre for Systems Biomedicine
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Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, 4367
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Malaria Research and Training Center
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Faculty of Pharmacy, Malaria Research and Training Center, Bamako, BP:1805
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School of Geography, Earth and Environmental Sciences, University of Birmingham, UK, Birmingham, B15 2TT
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Department of Chemistry, University of Tartu, Tartu, 50411
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Data Sciences and Quantitative Biology, Discovery Sciences, AstraZeneca, Cambridge
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Institut Pasteur · Institut Français de Bioinformatique
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Bioinformatics and Biostatistics Hub, Institut Pasteur, Paris, F-75015
Institut Français de Bioinformatique, Evry, F-91000
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Leibniz Institute of Plant Biochemistry
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Research group Bioinformatics and Scientific Data, Leibniz Institute of Plant Biochemistry, Halle, 06120
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Institute of Environmental Medicine, Karolinska Institute, Stockholm, 17177
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Innsbruck Medical University · Universität Innsbruck
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Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, Innsbruck, A-6020
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Institut de Recerca Biomèdica Catalunya Sud · Universitat Rovira i Virgili
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Institut d'Investigacio Sanitaria Pere Virgili-Universitat Rovira i Virgili, Tarragona, 43007
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Health Unit, Health, Mol, 2400
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Data Readiness Group, Department of Engineering Science, University of Oxford, Oxford
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Centre international de recherche sur le cancer
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International Agency for Research on Cancer, World Health Organisation, Lyon, 69372
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Department of Environment and Geography, University of York, UK, York, YO10 5NG
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Data Readiness Group, Department of Engineering Science, University of Oxford, Oxford
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Universitat Pompeu Fabra · Hospital Del Mar · Municipal Institute for Medical Research · Hospital del Mar Research Institute
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Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, 08003
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National Technical University of Athens
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National Technical University of Athens, Athens, 15780
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ELIXIR Hub, Wellcome Genome Campus, Cambridge, CB10 1SD
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Helmholtz Centre for Environmental Research
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Helmholtz Centre for Environmental Research - UFZ, Leipzig, 04318
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Environmental Institute, Koš, 97241
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Uppsala University · Science for Life Laboratory
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Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala University, Uppsala, SE-75124
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ELIXIR Hub, Wellcome Genome Campus, Cambridge, CB10 1SD
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National and Kapodistrian University of Athens
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Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, 15771
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School of Biosciences, University of Birmingham, UK, Birmingham, B15 2TT
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Gerard J. P. van Westen Aachen Division of Drug Discovery and Safety Leiden Academic Centre for Drug Research
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Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden, 2333 CC
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Karolinska University Hospital · Karolinska Institutet
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Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177
Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm SE-141-86
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Environmental Protection Agency
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Center for Computational Toxicology and Exposure, United States Environmental Protection Agency, Research Triangle Park, NC 27711
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Health Unit, Health, Mol, 2400
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Department of Pharmaceutical Sciences, University of Vienna, Vienna, 1090
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Department Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, 1000
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Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, 6229 ER
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