Advancing Electronic Biosensors with 2D Conjugated Metal–Organic Frameworks

Small, vol. 22, pp. e05697

Abstract

With their exceptionally high surface area, metal-organic frameworks (MOFs) have been well-positioned as ideal materials for catalysis, drug delivery, and energy storage. However, for electronic biosensing applications, their inherently poor charge transport capability hinders the propagation of electrical signals through the MOF framework, reducing the efficiency with which interfacial binding events are converted into measurable signals. This limitation greatly restricts the effective detection of target analytes in electronic biosensing systems. 2D conjugated metal-organic frameworks (2D c-MOFs) have emerged as promising alternatives, combining large surface area with enhanced charge transport, making them attractive for highly sensitive electronic biosensors. This paper presents a comprehensive overview of the latest developments in 2D-c-MOF-based electronic biosensors, focusing on point-of-care (PoC) health monitoring and diagnostics. The key progresses in material synthesis and device fabrication to enable ultrasensitive detection for a wide range of relevant biomolecules are highlighted. Furthermore, the performance of these biosensors in terms of sensitivity and specificity across a diverse array of biomarkers is evaluated. Finally, objective perspectives toward future research directions of 2D c-MOFs in PoC and personalized healthcare are offered.

Authors 4

1. Khanh Dien Le

   Griffith University

   Affiliation as printed

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI) Griffith University Nathan QLD 4111 Australia

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI), Griffith University, Nathan, QLD, 4111 Australia

2. Xuan Thang Vu Aachen Institute of Materials in Electrical Engineering 1

   RWTH Aachen University

   Affiliation as printed

   Institute of Materials in Electrical Engineering 1 RWTH Aachen University Sommerfeldstraße 24 52074 Aachen Germany

3. Tuan‐Khoa Nguyen corresponding

   Flinders University · Griffith University

   Affiliation as printed

   College of Science and Engineering Flinders University Tonsley SA 5042 Australia

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI) Griffith University Nathan QLD 4111 Australia

   College of Science and Engineering, Flinders University, Tonsley, SA, 5042 Australia

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI), Griffith University, Nathan, QLD, 4111 Australia

4. Nam‐Trung Nguyen corresponding

   Griffith University

   Affiliation as printed

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI) Griffith University Nathan QLD 4111 Australia

   Queensland Quantum and Advanced Technologies Research Institute (QUATRI), Griffith University, Nathan, QLD, 4111 Australia