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Abstract

An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization of in vivo models in pain research. Mammary cancer cells are often used to model metastatic bone pain in vivo, and are commonly used in both males and females. Here we demonstrate that compared to male rats, female rats have an increased capacity for recovery following inoculation of MRMT-1 mammary cells, thus potentially causing a sex-dependent bias in interpretation of the data.

Authors 4

1. Sarah Falk corresponding

   University of Copenhagen

   Affiliation as printed

   Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100

2. Tamara Al-Dihaissy

   University of Copenhagen

   Affiliation as printed

   Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100

3. Laura Mezzanotte Aachen Department of Radiology, Leiden University Medical Center

   Leiden University Medical Center

   Affiliation as printed

   Department of Radiology, Leiden University Medical Center, Leiden, 2333 ZA

4. Anne‐Marie Heegaard

   University of Copenhagen

   Affiliation as printed

   Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100