Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus
EULAR Rheumatology Open, vol. 1, pp. 380–393
Abstract
Objectives: To develop updated interdisciplinary clinical practice guidelines for the management of juvenile-onset systemic lupus erythematosus (jSLE) in a patient-centred, treat-to-target (T2T) approach. Methods: Recommendations were developed based on T2T principles around shared decision-making by a multidisciplinary team of experts including paediatric and adult rheumatologists, paediatric nephrologists, neurologists, cardiologists, pneumologists, radiologists, immunologists, and infectious disease specialists, geneticists, and ophthalmologists from Germany, Switzerland, Austria, the United Kingdom and Ireland, a psychologist, and a patient representative. The process followed the standard operating procedures of the German AWMF (Association of the Scientific Medical Societies in Germany). The team conducted an extensive literature review (2012-2024) of 40 clinically selected Population/Intervention/Comparison/Outcome questions. Overarching principles (OAP), overarching treatment strategies (OATS), and recommendations were formulated and explored in 2 online preconsensus meeting Delphi surveys with the experts. The results were discussed in 3 virtual consensus meetings using a modified nominal group technique to discuss, modify and vote on the OAP, OATS, and recommendations. All final document was approved by 2 external reviewers and the AWMF. Results: We reached consensus on 45 recommendations on the general assessment, diagnosis, monitoring, nonpharmacologic, and pharmacologic management of jSLE. We highlight organ-specific manifestations, such as central nervous system disease, jSLE-related antiphospholipid antibody syndrome, and juvenile lupus nephritis, and consider disease severity for treatment recommendations. Conclusions: We have developed updated interdisciplinary clinical practice guidelines to facilitate a patient-centred T2T approach to the management of patients with jSLE.
Authors 29
-
Affiliation as printed
Department of Pediatrics, Pediatric Rheumatology, Kinderkrankenhaus Amsterdamer Strasse, Cologne, Germany
-
University of Cologne · University Hospital Cologne
Affiliation as printed
Pediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany
-
Affiliation as printed
Department of Pediatrics, Division of Pediatric Neurology, RWTH Aachen University, Aachen, Germany
-
Leibniz Association · German Rheumatism Research Centre · Berlin Institute of Health at Charité - Universitätsmedizin Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
Deutsches Rheuma-Forschungszentrum (DRFZ), an institute of the Leibniz Association, Berlin, Germany
German Center for Child and Adolescent Health (DZKJ), Partner Site Berlin, Berlin, Germany
-
University College Dublin · University of Calgary
Affiliation as printed
Department of Pediatrics, Cumming School of Medicine, University of Calgary, AB, Canada
Rheumatology, Childrens Health Ireland, and University College Dublin, Ireland, Dublin, Ireland
-
Cincinnati Children's Hospital Medical Center · University of Cincinnati
Affiliation as printed
UC Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
-
Danube Private University · Innsbruck Medical University
Affiliation as printed
Department of Pediatrics, Medical University Innsbruck, Innsbruck and Department of Medicine,Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria
-
Universitätsklinikum Tübingen · University of Tübingen
Affiliation as printed
Centre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany
-
University Children’s Hospital Basel · University Hospital Carl Gustav Carus · Technische Universität Dresden
Affiliation as printed
Department of Pediatric Radiology, University Children`s Hospital Basel UKBB, Basel, Switzerland
Department of Radiology, Faculty of Medicine Carl Gustav Carus, TU, Dresden, Germany
-
University of Liverpool · Alder Hey Children's NHS Foundation Trust · Alder Hey Children's Hospital
Affiliation as printed
Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK
Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK
-
University of Münster · University Hospital Münster
Affiliation as printed
Department of Pediatric Rheumatology and Immunology, Münster University Hospital, Münster, Germany
-
Affiliation as printed
Center for Pediatric Rheumatology, Klinikum Stuttgart, Stuttgart, Germany
-
University of Cologne · University Hospital Cologne
Affiliation as printed
Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
-
Universität Ulm · University Hospital Ulm
Affiliation as printed
Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany
-
Affiliation as printed
Praxis Kamitz, Kinder- und Jugendmedizin und Kinderrheumatologie, Aachen, Germany
-
Technische Universität Dresden
Affiliation as printed
Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Dresden, Germany
-
Affiliation as printed
Division of Pediatric Cardiology and Rheumatology, University Hospital Essen, Essen, Germany
-
Technische Universität Dresden
Affiliation as printed
Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
-
Technische Universität Dresden
Affiliation as printed
Division of Rheumatology, Department of Medicine III, and University Centre for Autoimmune and Rheumatic Entities (UCARE), University Medical Centre and Faculty of Medicine, TU Dresden, Dresden, Germany
-
Affiliation as printed
Lupus Erythematodes Selbsthilfegemeinschaft e.V. (lupus patient organisation), Wuppertal, Germany
-
Medizinische Hochschule Hannover · German Center for Lung Research
Affiliation as printed
Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; German Center for Lung Research (DZL/BREATH), Hannover, Germany
-
Affiliation as printed
German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Dresden, Germany
-
University Medical Center Hamburg-Eppendorf
Affiliation as printed
Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
-
Affiliation as printed
Department of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany
-
Heinrich Heine University Düsseldorf
Affiliation as printed
Department of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany
-
Heidelberg University · University Hospital Heidelberg
Affiliation as printed
Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany
-
University Hospital of Bern · RWTH Aachen University
Affiliation as printed
Department of Pediatrics, Pediatric Rheumatology, Inselspital, Bern, Switzerland
Department of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany
-
Medizinische Hochschule Hannover
Affiliation as printed
Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
-
Technische Universität Dresden
Affiliation as printed
Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Dresden, Germany
Cited by 3 stored of 3
3 results
No patents citing this paper on Lens.org (checked 2026-10-06).