Open problems in ageing science: a roadmap for biogerontology
GeroScience, vol. 48, pp. 3351–3360
Abstract
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems in ageing and longevity science. These questions were collected through community engagement and further analysed using Natural Language Processing to assess their prevalence in the literature and to identify both well-established and emerging research gaps. The final list is categorised into different topics, including molecular and cellular mechanisms of ageing, comparative biology and the use of model organisms, biomarkers and the development of therapeutic interventions. Both long-standing questions and more recent and specific questions are featured. Our comprehensive compilation is available to the biogerontology community on our website ( www.longevityknowledge.app ). Overall, this work highlights current key research questions in ageing biology and offers a roadmap for fostering future progress in biogerontology.
Authors 28
-
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
-
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
-
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
-
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
-
Affiliation as printed
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
-
University of Cologne · Leiden University Medical Center · Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · Max Planck Institute for Biology of Ageing
Affiliation as printed
Cologne Excellence Cluster On Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany
Max Planck Institute for Biology of Ageing, 50931, Cologne, Germany
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2333 ZC, Leiden, Netherlands
-
ETH Zurich · Institute of Translational Medicine
Affiliation as printed
Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland
-
Affiliation as printed
Institute of Healthy Ageing, University College London, London, UK
-
Affiliation as printed
Department of Biology, University of Rochester, Rochester, NY, 14627, USA
-
National University of Singapore · National University Health System
Affiliation as printed
Center for Healthy Longevity, National University Health System, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
-
Affiliation as printed
Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet, Stockholm, Sweden
-
Affiliation as printed
Altos Labs, Cambridge, UK
-
Affiliation as printed
School of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA
-
Affiliation as printed
Longevity Escape Velocity Foundation, Francisco, CA, USA
-
National University of Singapore · Amsterdam Movement Sciences · Vrije Universiteit Amsterdam
Affiliation as printed
Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Van Der Boechorstsraat 7, 1081 BT, Amsterdam, Netherlands
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore, MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore, 117597, Singapore
-
Affiliation as printed
The Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA
-
Health Sciences North · University of Tübingen
Affiliation as printed
Health Sciences North Research Institute, Sudbury, ON, Canada
Institute of Immunology, University of Tuebingen, Tuebingen, Germany
-
Research Institute for Farm Animal Biology (FBN)
Affiliation as printed
Research Group Epigenetics, Metabolism and Longevity, Institute for Farm Animal Biology, 18196, Dummerstorf, Germany
-
Affiliation as printed
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
-
Affiliation as printed
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
-
University of Oslo · Akershus University Hospital
Affiliation as printed
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
-
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
-
University of Rochester Medicine
Affiliation as printed
Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14627, USA
-
Affiliation as printed
Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Ashby Rd, Loughborough, LE11 3TU, UK
-
Affiliation as printed
School of Biology and Environmental Science, University College Dublin, Dublin, Ireland
-
University of Tennessee Health Science Center
Affiliation as printed
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA
-
National University of Singapore
Affiliation as printed
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
The Thalion Initiative, 177 Huntington Avenue, 17 Floor, Boston, MA, 02115, USA
-
João Pedro de Magalhães corresponding
Affiliation as printed
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. jp@senescence.info
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
Cited by 12 stored of 12
12 results
No patents citing this paper on Lens.org (checked 2026-10-11).