Pericardial Closure Preserves Early Right Ventricular Function After Cardiac Surgery: A Retrospective Cohort Study

Journal of Cardiovascular Development and Disease, vol. 12, pp. 431

Abstract

Background: Perioperative right ventricular (RV) dysfunction is a frequent complication of cardiac surgery linked to poor outcomes and may result from the loss of pericardial support. We investigated whether pericardial closure preserves early postoperative RV function. Methods: We compared patients with pericardial closure versus open pericardium. Co-primary endpoints were early postoperative RV longitudinal function by tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular systolic velocity (TASV). Adjusted comparisons used analysis-of-covariance (postoperative value adjusted for baseline) with prespecified covariates (baseline outcome, LV global longitudinal strain, left-ventricular ejection fraction, LVEDVI, sex, procedure; cardiopulmonary bypass and cross-clamp times when available). Holm correction-controlled multiplicity across the co-primary endpoints. Sensitivity linear mixed-effects models (time × group) were performed. Results: Pericardial closure was associated with better early RV longitudinal function after multivariable adjustment. TAPSE: adjusted mean difference (AMD, Closed–Open) 1.531 mm (95% CI 0.130–2.931; p = 0.033). TASV: AMD 1.694 cm/s (95% CI 0.437–2.951; p = 0.009; Holm-adjusted p = 0.018). Sensitivity analyses yielded consistent estimates. Conclusions: Pericardial closure was independently associated with improved early RV longitudinal function. These adjusted findings address baseline LV imbalances and support considering closure to preserve RV performance; confirmation in prospective trials is warranted.

Authors 8

1. H.-W.M. Breuer Aachen Department of Cardiac Surgery Faculty of Medicine

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany

   Faculty of Medicine, RWTH University, 52074 Aachen, Germany

2. Marjolijn C. Sales Aachen Department of Cardiac Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany

3. Natasja W. M. Ramnath Aachen Department of Cardiac Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany

4. Yusuf Shieba

   South Valley University

   Affiliation as printed

   Department of Cardiothoracic Surgery, Faculty of Medicine, South Valley University, Qena 83523, Egypt

5. Alish Kolashov

   Krankenhaus der Barmherzigen Brüder Trier

   Affiliation as printed

   Department of Cardiothoracic Surgery, Heart Centre Trier, Barmherzigen Brueder Hospital, 54292 Trier, Germany

6. Ajay Kumar Moza Aachen Department of Cardiac Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany

7. Lachmandath Tewarie Aachen Department of Cardiac Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany

8. Rashad Zayat corresponding Aachen Department of Cardiac Surgery

   Universitätsklinikum Aachen · RWTH Aachen University

   Affiliation as printed

   Department of Cardiac Surgery, RWTH University Hospital, 52074 Aachen, Germany