Identifying Key Questions and Challenges in Microchimerism Biology
Advanced Science, vol. 12, pp. e14969
Abstract
Microchimerism research has recently gained renewed attention despite known existence of these rare cells for decades. Fetal and maternal microchimeric-derived cells may have functional capabilities, and are increasingly associated with both beneficial and adverse health outcomes. Yet, establishing the role of microchimerism in health has been largely constrained methodologically and theoretically. The Microchimerism, Human Health, and Evolution Project address these challenges by calling on 29 leading microchimerism experts to put forth key research questions that can substantially advance the field. Seven major categories are identified: function and mechanism; microchimerism in interventions, treatment, and transplant; mapping "generational microchimerism"; evolution; microchimerism detection; appropriate experimental model systems; and definition of microchimerism. Identifying these questions - and continuing to find answers - will be crucial for advancing the knowledge of microchimerism in health and disease.
Authors 32
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Kristine J. Chua corresponding
Affiliation as printed
Department of Anthropology University of Notre Dame Notre Dame 46556 USA
Department of Anthropology, University of Notre Dame, Notre Dame, 46556 USA
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Leiden University Medical Center
Affiliation as printed
Department of Immunology Leiden University Medical Center Leiden 2333 ZA Netherlands
Department of Immunology, Leiden University Medical Center, Leiden, 2333 ZA Netherlands
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Affiliation as printed
Department of Cell Biology Histology & Embryology Gottfried Schatz Research Center Medical University of Graz Graz 8010 Austria
Department of Cell Biology, Histology & Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, 8010 Austria
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Affiliation as printed
Center for Evolution and Medicine Arizona State University Tempe 85287 USA
Department of Psychology Arizona State University Tempe 85287 USA
Department of Psychology, Arizona State University, Tempe, 85287 USA
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University Medical Center Hamburg-Eppendorf
Affiliation as printed
Division of Feto‐Maternal Medicine Department of Obstetrics and Fetal Medicine University Medical Center Hamburg‐Eppendorf 20246 Hamburg Germany
Hamburg Center for Translational Immunology University Medical Center Hamburg‐Eppendorf 20246 Hamburg Germany
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
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National Institutes of Health · National Human Genome Research Institute · Eunice Kennedy Shriver National Institute of Child Health and Human Development
Affiliation as printed
National Human Genome Research Institute National Institutes of Health Bethesda 20892 USA
National Institute of Child Health and Human Development National Institutes of Health Bethesda 20892 USA
National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892 USA
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892 USA
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German Rheumatism Research Centre · Technische Universität Berlin
Affiliation as printed
German Rheumatology Research Center A Leibniz Institute (DRFZ) 10117 Berlin Germany
Technische Universität Berlin Department for Cytometry Institute of Biotechnology 13355 Berlin Germany
German Rheumatology Research Center, A Leibniz Institute (DRFZ), 10117 Berlin, Germany
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Affiliation as printed
Department of Chemistry Howard University Washington D.C. 20059 USA
Department of Chemistry, Howard University, Washington, D.C., 20059 USA
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Leiden University Medical Center
Affiliation as printed
Department of Immunology Leiden University Medical Center Leiden 2333 ZA Netherlands
Department of Immunology, Leiden University Medical Center, Leiden, 2333 ZA Netherlands
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Affiliation as printed
Division of Obstetrics and Gynaecology Oslo University Hospital Oslo 0424 Norway
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424 Norway
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Affiliation as printed
Department of Organismic and Evolutionary Biology Harvard University Cambridge 02138 USA
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, 02138 USA
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University of Washington · Seattle Children's Research Institute
Affiliation as printed
Center for Global Infectious Disease Research Seattle Children's Research Institute Seattle 98105 USA
Department of Pediatrics University of Washington School of Medicine Seattle 98195 USA
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, 98105 USA
Department of Pediatrics, University of Washington School of Medicine, Seattle, 98195 USA
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University of Cape Town · University of Exeter · Wellcome Centre for Infectious Diseases Research in Africa · MRC Centre for Medical Mycology · Institute of Infectious Disease and Molecular Medicine
Affiliation as printed
Institute for Infectious Disease and Molecular Medicine Centre for Infectious Disease Research in Africa and Division of Immunology University of Cape Town Cape Town 7701 South Africa
MRC Centre for Medical Mycology University of Exeter Exeter EX4 4QJ UK
Institute for Infectious Disease and Molecular Medicine, Centre for Infectious Disease Research in Africa and Division of Immunology, University of Cape Town, Cape Town, 7701 South Africa
MRC Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QJ UK
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Oslo University Hospital · University of Oslo
Affiliation as printed
Division of Obstetrics and Gynaecology Oslo University Hospital Oslo 0424 Norway
Faculty of Medicine University of Oslo Oslo 0316 Norway
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424 Norway
Faculty of Medicine, University of Oslo, Oslo, 0316 Norway
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Affiliation as printed
Department of Public Health University of Copenhagen Copenhagen DK‐1165 Denmark
Department of Public Health, University of Copenhagen, Copenhagen, DK-1165 Denmark
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Affiliation as printed
Translational Science and Therapeutics Division Fred Hutchinson Cancer Center Seattle 98109 USA
Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, 98109 USA
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Translational Research Institute · The University of Queensland
Affiliation as printed
Frazer institute The University of Queensland Woolloongabba 4072 Australia
Translational Research institute The University of Queensland Woolloongabba 4072 Australia
Translational Research institute, The University of Queensland, Woolloongabba, 4072 Australia
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Inserm · Aix-Marseille Université · ARTHritEs, Microchimérisme et InflammationS
Affiliation as printed
INSERM UMRs 1097 ARTHEMIS Aix Marseille University Marseille 13284 France
INSERM UMRs 1097, ARTHEMIS, Aix Marseille University, Marseille, 13284 France
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University of Washington · Fred Hutch Cancer Center
Affiliation as printed
Medicine, Rheumatology University of Washington and Fred Hutchinson Cancer Center Seattle 98109 USA
Medicine, Rheumatology, University of Washington and Fred Hutchinson Cancer Center, Seattle, 98109 USA
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Oslo University Hospital · University of Oslo
Affiliation as printed
Faculty of Medicine University of Oslo Oslo 0316 Norway
Research Institute of Internal Medicine Oslo University Hospital Oslo 0424 Norway
Faculty of Medicine, University of Oslo, Oslo, 0316 Norway
Research Institute of Internal Medicine, Oslo University Hospital, Oslo, 0424 Norway
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Affiliation as printed
Center for Studies in Demography and Ecology University of Washington Seattle 98195 USA
Center for Studies in Demography and Ecology, University of Washington, Seattle, 98195 USA
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University Medical Center Groningen · University of Groningen
Affiliation as printed
Obstetrics and Gynecology University Medical Center Groningen University of Groningen Groningen 9700 AB The Netherlands
Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, 9700 AB The Netherlands
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University of Bonn · University Hospital Bonn
Affiliation as printed
Department of Orthopedics and Trauma Surgery University Hospital Bonn 53127 Bonn Germany
Department of Orthopedics and Trauma Surgery, University Hospital Bonn, 53127 Bonn, Germany
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Oslo University Hospital · University of Oslo
Affiliation as printed
Division of Obstetrics and Gynaecology Oslo University Hospital Oslo 0424 Norway
Faculty of Medicine University of Oslo Oslo 0316 Norway
Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, 0424 Norway
Faculty of Medicine, University of Oslo, Oslo, 0316 Norway
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Science for Life Laboratory · Sahlgrenska University Hospital · Region Västra Götaland · Wallenberg Centre for Molecular and Translational Medicine · University of Gothenburg
Affiliation as printed
Department of Clinical Genetics and Genomics Sahlgrenska University Hospital Region Västra Götaland Gothenburg SE 413 45 Sweden
Sahlgrenska Center for Cancer Research Department of Laboratory Medicine Wallenberg Centre for Molecular and Translational Medicine Science for Life Laboratory Institute of Biomedicine Sahlgrenska Academy University of Gothenburg Gothenburg 405 30 Sweden
Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, Wallenberg Centre for Molecular and Translational Medicine, Science for Life Laboratory, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 405 30 Sweden
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University of California San Diego
Affiliation as printed
Pathology Center for Perinatal Discovery University of California San Diego La Jolla 92037 USA
Pathology, Center for Perinatal Discovery, University of California San Diego, La Jolla, 92037 USA
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University Medical Center Hamburg-Eppendorf
Affiliation as printed
Division of Feto‐Maternal Medicine Department of Obstetrics and Fetal Medicine University Medical Center Hamburg‐Eppendorf 20246 Hamburg Germany
Hamburg Center for Translational Immunology University Medical Center Hamburg‐Eppendorf 20246 Hamburg Germany
Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
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Cincinnati Children's Hospital Medical Center · University of Cincinnati
Affiliation as printed
Center for Inflammation and Tolerance Cincinnati Children's Hospital Cincinnati 45229 USA
University of Cincinnati College of Medicine Cincinnati 45219 USA
Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, 45229 USA
University of Cincinnati College of Medicine, Cincinnati, 45219 USA
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National Institutes of Health · National Human Genome Research Institute
Affiliation as printed
National Human Genome Research Institute National Institutes of Health Bethesda Bethesda 20892 USA
National Human Genome Research Institute, National Institutes of Health Bethesda, Bethesda, 20892 USA
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Albert Einstein College of Medicine
Affiliation as printed
Division of Endocrinology Department of Medicine Albert Einstein College of Medicine Bronx 10461 USA
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, 10461 USA
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Affiliation as printed
Department of Cell Biology Histology & Embryology Gottfried Schatz Research Center Medical University of Graz Graz 8010 Austria
Department of Cell Biology, Histology & Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, 8010 Austria
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Amy M. Boddy corresponding
University of California, Santa Barbara
Affiliation as printed
Department of Anthropology University of California Santa Barbara Santa Barbara 93106 USA
Department of Anthropology, University of California Santa Barbara, Santa Barbara, 93106 USA
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