Bone powder-laden hydrogel scaffolds in bone tissue engineering

Biomaterials Science, vol. 14, pp. 31–55

Abstract

studies using bone defect animal models have demonstrated that bone powder-laden hydrogel scaffolds exhibit favorable physicochemical properties, enhance the osteogenic behavior of osteogenesis-related cells, and improve the quality and efficiency of bone defect repair in animals. Bone powder-laden hydrogel scaffold can maximize the performance of individual components. However, this material has several limitations and has not yet been approved for clinical trials. Therefore, recent research has explored related products with superior properties, enhancing the mechanical, chemical, and biological characteristics of bone powder-laden hydrogel scaffolds, and proposed various strategies for improvement. This review summarizes the preparation procedures, therapeutic applications and possible improvements of various types of bone powder-laden hydrogel scaffolds.

Authors 5

1. Xinyi Shen

   Zhejiang University Medical College Affiliated Stomatological Hospital · Zhejiang University

   Affiliation as printed

   Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China

2. Danji Zhu

   Zhejiang University Medical College Affiliated Stomatological Hospital · Zhejiang University

   Affiliation as printed

   Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China

3. Lingkai Su

   Zhejiang University Medical College Affiliated Stomatological Hospital · Zhejiang University

   Affiliation as printed

   Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China

4. Gang Wu Aachen Department of Oral and Maxillofacial Surgery

   Leiden University Medical Center · Hangzhou Medical College

   Affiliation as printed

   Department of Oral and Maxillofacial Surgery, Leiden University Medical Center (LUMC), Leiden 2333 ZA, the Netherlands

   Savid School of Stomatology, Hangzhou Medical College, No. 8, Yikang Street, Hangzhou, Zhejiang 311399, China

5. Zhiwei Jiang

   Zhejiang University Medical College Affiliated Stomatological Hospital · Zhejiang University

   Affiliation as printed

   Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou 310000, China