Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis
NeuroImage, vol. 322, pp. 121554
Abstract
Abstract The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA produced stronger effect sizes and revealed findings in brain regions that traditional software overlooked due to missing voxel-data resulting in gaps in brain coverage. IBMMA has the potential to accelerate discoveries in neuroscience and enhance the clinical utility of neuroimaging findings.
Authors 93
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Affiliation as printed
Department of Psychology, University of Arizona, Tucson, AZ, USA
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Affiliation as printed
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
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Affiliation as printed
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
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Affiliation as printed
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
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University of Rochester Medicine · University of Rochester
Affiliation as printed
Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA
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The University of Melbourne · Orygen
Affiliation as printed
Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia; The University of Orygen, Parkville, Australia
Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia; Orygen, Parkville, Australia
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Affiliation as printed
Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia
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The University of Melbourne · Orygen
Affiliation as printed
Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia; The University of Orygen, Parkville, Australia
Centre for Youth Mental Health, The University of Melbourne, Parkville, Australia; Orygen, Parkville, Australia
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Affiliation as printed
Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands
Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
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University of Southern California
Affiliation as printed
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
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University of Southern California
Affiliation as printed
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
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University of Southern California
Affiliation as printed
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; ARQ National Psychotrauma Centre, Diemen, the Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; ARQ National Psychotrauma Centre, Diemen, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; De Viersprong Mental Health Specialist in Personality Disorders, Family and Behavior, Amsterdam, the Netherlands
De Viersprong mental health specialist in personality disorders, family and behavior, Amsterdam, The Netherlands; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Radboud University Nijmegen · Amsterdam Neuroscience · Amsterdam University Medical Centers · Donders Institute for Brain, Cognition and Behaviour · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, the Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Utrecht University · Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Clinical Psychology, Utrecht University, Utrecht, the Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands; Department of Clinical Psychology, Utrecht University, Utrecht, The Netherlands
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Chinese Academy of Sciences · Institute of Psychology, Chinese Academy of Sciences · University of Chinese Academy of Sciences
Affiliation as printed
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
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Chinese Academy of Sciences · Institute of Psychology, Chinese Academy of Sciences · University of Chinese Academy of Sciences
Affiliation as printed
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
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Chinese Academy of Sciences · Institute of Psychology, Chinese Academy of Sciences · University of Chinese Academy of Sciences
Affiliation as printed
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
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Affiliation as printed
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
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Affiliation as printed
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
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Columbia University Irving Medical Center · New York State Psychiatric Institute
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Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA
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New York State Psychiatric Institute
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New York State Psychiatric Institute, New York, NY, USA
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Affiliation as printed
University of Haifa, Haifa, Israel
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Affiliation as printed
Tel-Aviv University, Tel Aviv-Yafo, Israel
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
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Harvard University · McLean Hospital
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Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA
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Emory University · Wayne State University
Affiliation as printed
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA
Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
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Affiliation as printed
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
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Affiliation as printed
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
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Affiliation as printed
Department of Clinical Psychology, University of Groningen, Groningen, the Netherlands
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands
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Charité - Universitätsmedizin Berlin
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University Medical Centre Charité, Berlin, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
University Medical Centre Charité, Berlin, Germany
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Charité - Universitätsmedizin Berlin
Affiliation as printed
University Medical Centre Charité, Berlin, Germany
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Nic J.A. van der Wee Aachen
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Steven J.A. van der Werff Aachen
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Leiden University Medical Center
Affiliation as printed
Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim
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Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany; German Center for Mental Health, Partner Site Mannheim-Heidelberg-Ulm, Germany
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany; German Center for Mental Health, partner site Mannheim-Heidelberg-Ulm
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Heidelberg University · Central Institute of Mental Health · Medizinische Fakultät Mannheim
Affiliation as printed
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany; German Center for Mental Health, Partner Site Mannheim-Heidelberg-Ulm, Germany
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany; German Center for Mental Health, partner site Mannheim-Heidelberg-Ulm
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Central European Institute of Technology · Masaryk University · Central European Institute of Technology – Masaryk University
Affiliation as printed
CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic
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Central European Institute of Technology · Masaryk University · Central European Institute of Technology – Masaryk University · St. Anne's University Hospital Brno
Affiliation as printed
CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic; First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic
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Harvard University · McLean Hospital
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Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Womens Mental Health, McLean Hospital, Belmont, MA, USA
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Harvard University · McLean Hospital
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Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA
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Harvard University · McLean Hospital
Affiliation as printed
Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA
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Harvard University · McLean Hospital
Affiliation as printed
Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA
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Harvard University · McLean Hospital
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Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA
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Affiliation as printed
Department of Psychiatry, Texas A&M University, Bryan, TX, USA
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University of Minnesota · Minneapolis VA Health Care System · Minneapolis VA Medical Center
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Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
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University of Minnesota · Minneapolis VA Health Care System · Minneapolis VA Medical Center
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Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA
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Minneapolis VA Health Care System
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Minneapolis VA Health Care System, Minneapolis, MN, USA
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Affiliation as printed
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
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Affiliation as printed
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany
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Nanjing General Hospital of Nanjing Military Command · Nanjing University
Affiliation as printed
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
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Nanjing Drum Tower Hospital · Nanjing University
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Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China
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Department of Psychiatry, University of Toledo, Toledo, OH, USA
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Department of Psychiatry, University of Toledo, Toledo, OH, USA
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Affiliation as printed
Department of Psychiatry, University of Toledo, Toledo, OH, USA
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UNSW Sydney · Neuroscience Research Australia
Affiliation as printed
School of Psychology, University of New South Wales, Sydney, NSW, Australia; Neuroscience Research Australia, Randwick, NSW, Australia
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Université de Tours · Inserm · Imaging, Brain, and Neuropsychiatry
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Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032, Tours, France
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Department of Psychology, University of Minnesota, Minneapolis, MN, USA
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Affiliation as printed
Department of Psychology, University of Minnesota, Minneapolis, MN, USA
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University of Missouri–St. Louis
Affiliation as printed
University of Missouri-St. Louis, Department of Psychological Sciences, Center for Trauma Recovery, St. Louis, MO, USA
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The University of Texas at Austin
Affiliation as printed
Department of Psychiatry, University of Texas at Austin, Austin, TX, USA
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Affiliation as printed
Northwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA
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University of Wisconsin–Madison
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School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
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University of Wisconsin–Madison
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Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA
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University of Wisconsin–Madison
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Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA
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University of Wisconsin–Madison
Affiliation as printed
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA
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Affiliation as printed
Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, WI, USA; Comprehensive Injury Center, Medical College of Wisconsin, WI, USA
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Affiliation as printed
Comprehensive Injury Center, Medical College of Wisconsin, WI, USA; Department of Epidemiology, Institute of Health and Equity, Medical College of Wisconsin, WI, USA
Department of Epidemiology, Institute of Health and Equity, Medical College of Wisconsin, WI, USA; Comprehensive Injury Center, Medical College of Wisconsin, WI, USA
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Affiliation as printed
Department of Psychology, Marquette University, Milwaukee, WI, USA
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University of California San Diego
Affiliation as printed
Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Stein Institute for Research on Aging & Center for Healthy Aging, University of California San Diego, San Diego, CA, USA
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University of California San Diego
Affiliation as printed
Department of Psychiatry, University of California San Diego, San Diego, CA, USA
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University of California San Diego
Affiliation as printed
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA
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Affiliation as printed
Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA
Dept. of Psychological & Brain Sciences, Boston University, Boston, MA, USA
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University of California San Diego · VA San Diego Healthcare System · Center of Excellence for Stress and Mental Health
Affiliation as printed
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, LA Jolla, CA, USA
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Vanderbilt University Medical Center
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Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, TN, USA
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University of Nebraska Medical Center
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University of Nebraska Medical Center, Munroe-Meyer Institute, Omaha, NE, USA
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Affiliation as printed
Department of Psychology, Vanderbilt University, TN, USA
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Washington University in St. Louis
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Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA
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Baylor College of Medicine · Yale University
Affiliation as printed
Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
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Affiliation as printed
Department of Neuroscience, Western University, London, ON, Canada; Department of Psychiatry, Western University, London, ON, Canada
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Affiliation as printed
Department of Psychiatry, Western University, London, ON, Canada
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Affiliation as printed
Department of Psychiatry, Western University, London, ON, Canada
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Affiliation as printed
Department of Psychiatry, Western University, London, ON, Canada
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University of Southern California
Affiliation as printed
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
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Affiliation as printed
Brain Imaging and Analysis Center, Duke University, Durham, NC, USA; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA. Electronic address: Delin.Sun@duke.edu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA. Electronic address: Delin.Sun@duke.edu
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