P03.22.A USE OF POSITRON EMISSION TOMOGRAPHY (PET) IN PATIENTS WITH BRAIN TUMOURS AMONG EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER - BRAIN TUMOUR GROUP (EORTC-BTG) SITES
Neuro-Oncology, vol. 27, pp. iii56
Abstract
Abstract BACKGROUND Data on the use of positron emission tomography (PET) among neuro-oncology centers in Europe are scarce. MATERIAL AND METHODS From 06/2024 to 08/2024, a cross-sectional survey among European Organization for Research and Treatment in Cancer - Brain Tumor Group (EORTC-BTG) sites was performed to gain insights into the availability and use of PET across brain tumor centers in Europe. RESULTS In total, 312 sites were invited, and 103 replies from 20 countries were recorded. PET was available at 96/103 (93.2%) sites, and 74 of these reported PET use in patients with central nervous system neoplasms. Most frequently, PET was performed in glioma (69/74, 93.2%), followed by brain metastasis (58/74, 78.4%), meningioma (52/74, 70.3%), and CNS lymphoma (46/74, 62.2%). Amino acid PET was performed at 62/71 sites (87.3%, 3 not reported [n.r.]), and most frequently in glioma (58/59, 98.3%) and for differentiation of treatment-related changes from tumour progression (58/59, 98.3%). The prevailing amino acid tracer was [18F]FET (45/59, 76.3%), followed by [18F]FDOPA (22/59, 37.3%) and [11C]methionine (15/59, 25.4%). Dynamic acquisition protocols for amino acid PET were used by 35/59 (59.3%) sites. Somatostatin receptor (SSTR) PET was applied at 50/68 sites (73.5%, 6 n.r.) and mainly in meningioma (48/49, 98.0%) and for patient selection before radioligand therapy (41/49, 83.7%) as well as for target volume definition in radiotherapy (33/49, 67.3%). PET was reportedly covered by statutory health insurance at 46/59 (78.0%) centres for amino acid PET and 33/49 (67.3%) for SSTR PET. Reasons for not using PET in clinical routine included limited availability of tracers (14/29, 48.3%), high cost (11/29, 37.9%), and PET not perceived necessary (8/29, 27.6%). CONCLUSION PET is widely used within the EORTC BTG network, underscoring the feasibility of PET-based clinical trial endpoints which support the generation of evidence for further implementation in clinical routine. As our survey may be prone to selection and non-response bias, a comprehensive analysis of PET application patterns would be desirable.
Authors 25
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Ludwig-Maximilians-Universität München · Medical University of Vienna · LMU Klinikum
Affiliation as printed
Department of Nuclear Medicine, LMU University Hospital, LMU Munich , Munich,
Division of Oncology, Department of Medicine I, Medical University of Vienna , Vienna,
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany
Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
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RWTH Aachen University · Universitätsklinikum Aachen · Forschungszentrum Jülich
Affiliation as printed
Department of Nuclear Medicine, RWTH Aachen University Hospital , Aachen,
Institute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich , Juelich,
Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany
Institute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich, Juelich, Germany
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Forschungszentrum Jülich · University of Cologne · University Hospital Cologne
Affiliation as printed
Dept. of Neurology, Department of Neurology, Faculty of Medicine and University Hospital Cologne , Cologne,
Institute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich , Juelich,
Dept. of Neurology, Department of Neurology, Faculty of Medicine and University Hospital Cologne, Cologne, Germany
Institute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich, Juelich, Germany
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Lund University · Skåne University Hospital
Affiliation as printed
Department of Hematology, Oncology and Radiophysics, Skåne University Hospital , Lund,
Division of Oncology, Department of Clinical Sciences, Lund University , Lund,
Division of Oncology, Department of Clinical Sciences, Lund University, Lund, Sweden
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University of Oslo · Oslo University Hospital
Affiliation as printed
Department of Oncology, Oslo University Hospital , Oslo,
Institute for Clinical Medicine, University of Oslo , Oslo,
Department of Oncology, Oslo University Hospital, Oslo, Norway
Institute for Clinical Medicine, University of Oslo, Oslo, Norway
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Maastricht University Medical Centre
Affiliation as printed
Neuro-Oncology, Department of Neurology, GROW School for Oncology and Reproduction, Maastricht University Medical Centre , Maastricht,
Neuro-Oncology, Department of Neurology, GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, Netherlands
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Affiliation as printed
Department of Experimental and Clinical Medicine, Nuclear Medicine Unit, Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro , Catanzaro,
Department of Experimental and Clinical Medicine, Nuclear Medicine Unit, Department of Experimental and Clinical Medicine, "Magna Graecia" University of Catanzaro, Catanzaro, Italy
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Affiliation as printed
Department of Radiation Oncology, Iridium Cancer Network, Wilrijk (Antwerp), Belgium
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Lyon 1 Université · Hospices Civils de Lyon · Hôpital Pierre Wertheimer
Affiliation as printed
Department of Neurooncology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon , Bron,
Université Claude Bernard Lyon 1 , Villeurbanne,
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Humboldt-Universität zu Berlin · Charité - Universitätsmedizin Berlin
Affiliation as printed
Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology , Berlin,
German Cancer Consortium (DKTK), partner site Berlin, a partnership between DKFZ and Charité – Universitätsmedizin Berlin , Berlin,
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Danube Private University · Universität für Weiterbildung Krems
Affiliation as printed
Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Faculty of Medicine and Dentistry, Danube Private University , Krems,
Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria
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University of Gothenburg · Sahlgrenska University Hospital
Affiliation as printed
Department of Neurosurgery, Sahlgrenska University Hospital , Gothenburg,
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy , Gothenburg,
Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, Gothenburg, Sweden
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Affiliation as printed
Department of Radiation Oncology, University Hospital Tuebingen , Tuebingen,
Department of Radiation Oncology, University Hospital Tuebingen, Tuebingen, Austria
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University of Turin · Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
Affiliation as printed
Division of Neuro-Oncology, Department of Neuroscience, Division of Neuro-Oncology, Department of Neuroscience “Rita Levi Montalcini”, University and City of Health and Science Hospital , Turin,
Division of Neuro-Oncology, Department of Neuroscience, Division of Neuro-Oncology, Department of Neuroscience "Rita Levi Montalcini", University and City of Health and Science Hospital, Turin, Italy
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Affiliation as printed
Department of Medical Oncology, University Hospital Antwerp , Edegem,
Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium
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Affiliation as printed
Third Department of Medical Oncology, Hygeia Hospital , Athens,
Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece
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Heidelberg University · German Cancer Research Center · Deutsches Konsortium für Translationale Krebsforschung
Affiliation as printed
Department of Neuropathology, Institute of Pathology, Clinical Cooperation Unit Neuropathology, Ruprecht-Karls University Heidelberg, and German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ) , Heidelberg,
Department of Neuropathology, Institute of Pathology, Clinical Cooperation Unit Neuropathology, Ruprecht-Karls University Heidelberg, and German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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Erasmus MC · Erasmus MC Cancer Institute
Affiliation as printed
Brain Tumour Centre, Erasmus MC Cancer Institute , Rotterdam,
Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Centre Rotterdam , Rotterdam,
Brain Tumour Centre, Erasmus MC Cancer Institute, Rotterdam, Netherlands
Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
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University Medical Center Utrecht
Affiliation as printed
Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht , Utrecht,
Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht, Utrecht, Netherlands
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Inserm · Université de Lorraine · Centre Hospitalier Régional et Universitaire de Nancy · Imagerie Adaptative Diagnostique et Interventionnelle
Affiliation as printed
Department of Nuclear Medicine, Department of Nuclear Medicine & Nancyclotep Imaging Platform, CHRU Nancy and IADI INSERM, UMR 1254, Université de Lorraine , Nancy,
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University of Zurich · University Hospital Zurich
Affiliation as printed
Department of Medical Oncology and Hematology, Brain Tumor Center, University Hospital and University of Zurich , Zurich,
Department of Medical Oncology and Hematology, Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland
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Sapienza University of Rome · Istituto Neurologico Mediterraneo
Affiliation as printed
Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome , Rome,
IRCCS Neuromed, Pozzilli (IS), Italy
Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy
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University of Zurich · University Hospital Zurich
Affiliation as printed
Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich , Zurich,
Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland
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Affiliation as printed
Division of Oncology, Department of Medicine I, Medical University of Vienna , Vienna,
Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria
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Ludwig-Maximilians-Universität München · LMU Klinikum
Affiliation as printed
Department of Nuclear Medicine, LMU University Hospital, LMU Munich , Munich,
Department of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany
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