Bioengineered Violet Phosphorus Hybrid Nanoassembly for Pathogen‐Specific Eradication of Multidrug‐Resistant Bacteria
Advanced Functional Materials, vol. 36
Abstract
Abstract As an emerging 2D material, violet phosphorus nanosheet (VPN) has gained considerable attention since its first coverage in 2019. However, its potential in biomedical applications remains largely unexplored. Herein, a VPN‐based hybrid nanoassembly is presented for specific navigation and eradication of methicillin‐resistant Staphylococcus aureus (MRSA). Particularly, macrophage membrane preconditioned with MRSA is extracted to construct a bioengineered nanoshell, which is further cloaked onto vancomycin (Van)‐loaded, photodynamically active VPN to fabricate Van/VPN@M for combating multidrug‐resistant (MDR) bacteria‐related local skin infections. Leveraging this bioinspired coating, Van/VPN@M enables precise, infection site‐targeted delivery and synergistic antibacterial action. Upon laser irradiation, Van/VPN@M completely eradicates MDR bacteria, relieves local inflammation, and promotes skin repair in murine models of MRSA‐infected wound and subcutaneous abscess. Collectively, this versatile antibacterial platform not only expands the biomedical applicability of VPN, but also holds great promise to advance the therapeutic options for MDR bacteria‐associated infections.
Authors 15
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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Leibniz Institute of Polymer Research
Affiliation as printed
Leibniz‐Institut für Polymerforschung Dresden e.V. Hohe Straße 6 01069 Dresden Germany
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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Jinying Zhang corresponding
State Key Laboratory of Electrical Insulation and Power Equipment · Xi'an Jiaotong University
Affiliation as printed
State Key Laboratory of Electrical Insulation and Power Equipment Center of Nanomaterials for Renewable Energy School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 P. R. China
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Universitätsklinikum Aachen · RWTH Aachen University
Affiliation as printed
Institute for Experimental Molecular Imaging Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering RWTH Aachen University 52074 Aachen Germany
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Wei Wang corresponding
China Pharmaceutical University
Affiliation as printed
NMPA Key Laboratory for Research and Evaluation of Cosmetics China Pharmaceutical University Nanjing 211198 P. R. China
State Key Laboratory of Natural Medicines Department of Pharmaceutics School of Pharmacy China Pharmaceutical University Nanjing 211198 P. R. China
Wuxi Research Center for Innovative Medicines and Life Health Wuxi Innovation Research Institute of China Pharmaceutical University Wuxi 214112 P. R. China
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