September 16, 2025 article Loop engineering in enzymes from structure to function: Mechanisms, methodologies, and engineering strategies Biotechnology Advances DOI: 10.1016/j.biotechadv.2025.108716 OpenAlex Authors 0 Author list not loaded yet. Cited by 0 stored of 18 References 4 Search Sort Most cited Newest Oldest Patent citations Title Any typearticle review book-chapter conference-paper preprint dissertation book dataset other Any fieldAgricultural and Biological Sciences Arts and Humanities Biochemistry, Genetics and Molecular Biology Business, Management and Accounting Chemical Engineering Chemistry Computer Science Decision Sciences Dentistry Earth and Planetary Sciences Economics, Econometrics and Finance Energy Engineering Environmental Science Health Professions Immunology and Microbiology Materials Science Mathematics Medicine Neuroscience Nursing Pharmacology, Toxicology and Pharmaceutics Physics and Astronomy Psychology Social Sciences Veterinary Open access Flexibility Regulation of Loops Surrounding the Tunnel Entrance in Cytochrome P450 Enhanced Substrate Access Substantially 2022 ACS Catalysis article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization 80 citations Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design 2022 ACS Chemical Biology article Biochemistry, Genetics and Molecular Biology Enzyme Catalysis and Immobilization 47 citations Allosteric control of Ubp6 and the proteasome via a bidirectional switch 2022 Nature Communications article Biochemistry, Genetics and Molecular Biology Ubiquitin and proteasome pathways Open access 44 citations A low-barrier proton shared between two aspartates acts as a conformational switch that changes the substrate specificity of the β-lactamase BlaC 2024 International Journal of Biological Macromolecules article Biochemistry, Genetics and Molecular Biology Antibiotic Resistance in Bacteria Open access 7 citations 4 results