Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium
Molecular Psychiatry, vol. 31, pp. 1177–1189
Abstract
Abstract Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults. To bridge this gap, we established the Methylation, Imaging and NeuroDevelopment (MIND) Consortium, which aims to bring a developmental focus to the emerging field of Neuroimaging Epigenetics by (i) promoting collaborative, adequately powered developmental research via multi-cohort analyses; (ii) increasing scientific rigor through the establishment of shared pipelines and open science practices; and (iii) advancing our understanding of DNA methylation-brain dynamics at different developmental periods (from birth to emerging adulthood), by leveraging data from prospective, longitudinal pediatric studies. MIND currently integrates 16 cohorts worldwide, comprising (repeated) measures of DNA methylation in peripheral tissues (blood, buccal cells, and saliva) and neuroimaging by magnetic resonance imaging across up to five time points over a period of up to 21 years (N pooled DNAm = 12,877; N pooled neuroimaging = 10,899; N pooled combined = 6074). By triangulating associations across multiple developmental time points and study types, we hope to generate new insights into the dynamic relationships between peripheral DNA methylation and the brain, and how these ultimately relate to neurodevelopmental and psychiatric phenotypes.
Authors 47
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Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
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Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
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Affiliation as printed
Department of Psychology, University of Bath, Bath, UK
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Affiliation as printed
Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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Finnish Institute for Health and Welfare
Affiliation as printed
National Institute of Health and Welfare, Department of Public Health and Welfare, Population Health Unit, Helsinki, Finland
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Affiliation as printed
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
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Affiliation as printed
Department of Psychology, University of Bath, Bath, UK
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University of Turku · Turku University Hospital
Affiliation as printed
Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center; Department of Clinical Medicine, University of Turku, Turku, Finland
Department of Clinical Medicine, University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center
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Affiliation as printed
Michigan State University, East Lansing, MI, USA
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University of California, Irvine · Charité - Universitätsmedizin Berlin
Affiliation as printed
Department of Medical Psychology, Charité - Universitätsmedizin Berlin, Berlin, Germany
Department of Pediatrics, University of California, Irvine, CA, USA
Development, Health and Disease Research Program, University of California, Irvine, CA, USA
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Royal Children's Hospital · Deakin University · The University of Melbourne · Murdoch Children's Research Institute
Affiliation as printed
Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, VIC, Australia
Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC, Australia
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia
Deakin University, IMPACT – The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, VIC, Australia
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University of Cape Town · Red Cross War Memorial Children's Hospital
Affiliation as printed
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa
Neuroscience Institute, University of Cape Town, Cape Town, South Africa
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Agency for Science, Technology and Research · National University of Singapore
Affiliation as printed
Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
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Affiliation as printed
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
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Affiliation as printed
Department of Psychology, University of Bath, Bath, UK
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Aarhus University · Pontifícia Universidade Católica do Rio Grande do Sul
Affiliation as printed
School of Medicine, Developmental Cognitive Neuroscience Lab, Pontifical Catholic University of Rio Grande Do Sul (PUCRS), Porto Alegre, Brazil
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
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Affiliation as printed
Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
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Affiliation as printed
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
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Oregon Health & Science University
Affiliation as printed
Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA
Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA
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University of Turku · Turku University Hospital
Affiliation as printed
Department of Psychiatry, Turku University Hospital & University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center; Department of Clinical Medicine, University of Turku, Turku, Finland
Department of Clinical Medicine, University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center
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University of Turku · Turku University Hospital
Affiliation as printed
Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland
Department of Child Psychiatry, Turku University Hospital, Turku, Finland
Department of Clinical Medicine, Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center; Department of Clinical Medicine, University of Turku, Turku, Finland
Department of Clinical Medicine, University of Turku, Turku, Finland
FinnBrain Birth Cohort Study, Turku Brain and Mind Center
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South African Medical Research Council · University of Cape Town
Affiliation as printed
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Neuroscience Institute, University of Cape Town, Cape Town, South Africa
SAMRC Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa
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Affiliation as printed
Department of Psychology, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK
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University of Michigan · Institute for Social Research
Affiliation as printed
Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
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University of Michigan · Institute for Social Research
Affiliation as printed
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
Institute for Social Research, University of Michigan, Ann Arbor, MI, USA
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Oregon Health & Science University · OHSU Knight Cancer Institute
Affiliation as printed
Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA
Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA
Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
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Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
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Oregon Health & Science University
Affiliation as printed
Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA
Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA
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Universidade Federal de São Paulo
Affiliation as printed
Federal University of São Paulo, São Paulo, Brazil
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Affiliation as printed
Department of Molecular Biology, Princeton University, Princeton, NJ, USA
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National University of Singapore
Affiliation as printed
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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University of Rochester Medicine
Affiliation as printed
University of Rochester Medical Center, Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, Rochester, NY, USA
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Affiliation as printed
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA
Yale Child Study Center, Yale School of Medicine, New Haven, CT, USA
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Universidade Federal de São Paulo
Affiliation as printed
Federal University of São Paulo, São Paulo, Brazil
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University of Helsinki · Helsinki University Hospital · Finnish Institute for Health and Welfare
Affiliation as printed
National Institute of Health and Welfare, Department of Public Health and Welfare, Population Health Unit, Helsinki, Finland
Sleepwell program and Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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Oregon Health & Science University · OHSU Knight Cancer Institute
Affiliation as printed
Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA
Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA
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Royal Children's Hospital · The University of Melbourne · Murdoch Children's Research Institute
Affiliation as printed
Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC, Australia
Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia
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Universidade Federal do Rio Grande do Sul · Child Mind Institute
Affiliation as printed
Child Mind Institute, New York, NY, USA
Department of Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
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Royal Children's Hospital · The University of Melbourne · Murdoch Children's Research Institute
Affiliation as printed
Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, VIC, Australia
Developmental Imaging, Murdoch Children's Research Institute, Parkville, VIC, Australia
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Deakin University · Murdoch Children's Research Institute
Affiliation as printed
Developmental Imaging, Murdoch Children's Research Institute, Parkville, VIC, Australia
School of Psychology and Centre for Social and Early Emotional Development (SEED), Deakin University, Geelong, VIC, Australia
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South African Medical Research Council
Affiliation as printed
SAMRC Unit on Risk and Resilience in Mental Disorders, Cape Town, South Africa
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Agency for Science, Technology and Research · National University of Singapore
Affiliation as printed
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
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Agency for Science, Technology and Research · Bioinformatics Institute
Affiliation as printed
Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
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Agency for Science, Technology and Research · Bioinformatics Institute
Affiliation as printed
Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
Institute for Human Development and Potential (IHDP), Agency for Science Technology and Research (A*STAR), Singapore, Singapore
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University of Cape Town · Red Cross War Memorial Children's Hospital
Affiliation as printed
Department of Paediatrics & Child Health, Red Cross Children's Hospital and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa
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Esther Walton corresponding
Affiliation as printed
Department of Psychology, University of Bath, Bath, UK. E.Walton@bath.ac.uk
Department of Psychology, University of Bath, Bath, UK
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Charlotte A. M. Cecil corresponding Aachen Molecular Epidemiology Department of Biomedical Data Sciences
Leiden University Medical Center · Erasmus MC
Affiliation as printed
Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. c.cecil@erasmusmc.nl
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands. c.cecil@erasmusmc.nl
Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands
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