Cerebrovascular Reactivity at Rest and Its Association With Cognitive Function in People With Genetic Frontotemporal Dementia
Neurology, vol. 105, pp. e213677
Abstract
BACKGROUND AND OBJECTIVES: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition. METHODS: < 0.05. RESULTS: = 0.008, 95% CI 0.04-0.15), particularly in the prefrontal cortex, in sequence variation carriers across the sample, independent of disease stage. DISCUSSION: CVR impairment in genetic FTD has a predilection for the middle frontal and posterior cortex, and its preservation may yield a cognitive benefit for at-risk individuals. Although findings do not provide causality and warrant replication, they support the notion that vascular dysfunction in familial FTD may be a target for biomarker identification and disease-modifying efforts.
Authors 98
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University of Cambridge · Leiden University Medical Center
Affiliation as printed
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom;
Department of Radiology, Leiden University Medical Center, the Netherlands;
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UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Dementia Research Center, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom;
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UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Dementia Research Center, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom;
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UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Dementia Research Center, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom;
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UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Dementia Research Center, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom;
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Affiliation as printed
Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands;
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Affiliation as printed
Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands;
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Affiliation as printed
Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands;
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Hospital Clínic de Barcelona · Universitat de Barcelona
Affiliation as printed
Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Spain;
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Affiliation as printed
Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Canada;
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Karolinska University Hospital · Karolinska Institutet
Affiliation as printed
Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet, Solna, Sweden;
Unit for Hereditary Dementias, Theme Inflammation and Agеing, Karolinska University Hospital, Solna, Sweden;
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University of Milan · Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Affiliation as printed
Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy;
University of Milan, Centro Dino Ferrari, Italy;
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Universitair Ziekenhuis Leuven · KU Leuven
Affiliation as printed
Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium;
Leuven Brain Institute, KU Leuven, Belgium;
Neurology Service, University Hospitals Leuven, Belgium;
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Affiliation as printed
Faculty of Medicine, University of Lisbon, Portugal;
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Affiliation as printed
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy;
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Unidade Local de Saúde de Coimbra · University of Coimbra
Affiliation as printed
Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Portugal;
University Hospital of Coimbra (HUC), Neurology Service, Faculty of Medicine, University of Coimbra, Portugal;
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University of Manchester · Essen University Hospital · Stiftung Universitätsmedizin Essen · University of Duisburg-Essen
Affiliation as printed
Department of Geriatric Medicine, Klinikum Hochsauerland, Arnsberg, Germany;
Department of Nuclear Medicine, Center for Translational Neuro- and Behavioural Sciences, University Medicine Essen, Germany;
Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Center, University of Manchester, United Kingdom;
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German Center for Neurodegenerative Diseases · Munich Cluster for Systems Neurology · Ludwig-Maximilians-Universität München
Affiliation as printed
Department of Neurology, Ludwig-Maximilians Universität München, Germany;
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany;
Munich Cluster of Systems Neurology (SyNergy), Germany;
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Affiliation as printed
Department of Neurofarba, University of Florence, Italy;
IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy;
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Affiliation as printed
Department of Neurology, University of Ulm, Germany;
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Montreal Neurological Institute and Hospital · McGill University Health Centre · McGill University
Affiliation as printed
Department of Psychiatry, McGill University Health Center, McGill University, Montreal, Québec, Canada;
McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Québec, Canada;
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University of Oxford · Imperial College London
Affiliation as printed
Department of Brain Sciences, Imperial College London, United Kingdom;
Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, United Kingdom;
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Centre National de la Recherche Scientifique · Inserm · Sorbonne Université · Assistance Publique – Hôpitaux de Paris · Pitié-Salpêtrière Hospital · Institut du Cerveau
Affiliation as printed
Centre de référence des démences rares ou précoces, IM2A, Département de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France;
Département de Neurologie, AP-HP - Hôpital Pitié-Salpêtrière, Paris, France;
Sorbonne Université, Paris Brain Institute – Institut du Cerveau – ICM, Inserm U1127, CNRS UMR 7225, AP-HP - Hôpital Pitié-Salpêtrière, France;
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Affiliation as printed
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada;
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Affiliation as printed
Tanz Center for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada;
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Sunnybrook Health Science Centre · University of Toronto · Sunnybrook Research Institute
Affiliation as printed
Sunnybrook Health Sciences Center, Sunnybrook Research Institute, University of Toronto, Ontario, Canada;
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Hertie Institute for Clinical Brain Research · University of Tübingen
Affiliation as printed
Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany;
Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Germany;
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Biogipuzkoa Health Research Institute · Donostiako Unibertsitate Ospitalea
Affiliation as printed
Cognitive Disorders Unit, Department of Neurology, Donostia Universitary Hospital, San Sebastian, Spain;
Neuroscience Area, Biodonostia Health Research Institute, San Sebastian, Gipuzkoa, Spain;
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Centro San Giovanni di Dio Fatebenefratelli · University of Brescia
Affiliation as printed
Department of Clinical and Experimental Sciences, University of Brescia, Italy;
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy;
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UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Dementia Research Center, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom;
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Louise van der Weerd Aachen Department of Human Genetics Department of Radiology, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
Department of Human Genetics, Leiden University Medical Center, the Netherlands;
Department of Radiology, Leiden University Medical Center, the Netherlands;
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James Benedict Rowe corresponding
MRC Cognition and Brain Sciences Unit · University of Cambridge
Affiliation as printed
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom;
MRC Cognition and Brain Science Unit, University of Cambridge, United Kingdom; and
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Kamen A. Tsvetanov corresponding
Affiliation as printed
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom;
Department of Psychology, University of Cambridge, United Kingdom
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