A brain-wide map of neural activity during complex behaviour
Nature, vol. 645, pp. 177–191
Abstract
. It is difficult to meet this challenge if different laboratories apply different analyses to different recordings in different regions during different behaviours. Here we report a comprehensive set of recordings from 621,733 neurons recorded with 699 Neuropixels probes across 139 mice in 12 laboratories. The data were obtained from mice performing a decision-making task with sensory, motor and cognitive components. The probes covered 279 brain areas in the left forebrain and midbrain and the right hindbrain and cerebellum. We provide an initial appraisal of this brain-wide map and assess how neural activity encodes key task variables. Representations of visual stimuli transiently appeared in classical visual areas after stimulus onset and then spread to ramp-like activity in a collection of midbrain and hindbrain regions that also encoded choices. Neural responses correlated with impending motor action almost everywhere in the brain. Responses to reward delivery and consumption were also widespread. This publicly available dataset represents a resource for understanding how computations distributed across and within brain areas drive behaviour.
Authors 96
-
Affiliation as printed
Center for Computational Neuroscience, University of Washington, Seattle, WA, USA
-
Affiliation as printed
Center for Neural Science, New York University, New York, NY, USA
New York University, New York, NY, USA
-
Affiliation as printed
Center for Neural Science, New York University, New York, NY, USA
New York University, New York, NY, USA
-
Affiliation as printed
Center for Neural Science, New York University, New York, NY, USA
-
Affiliation as printed
Center for Neural Science, New York University, New York, NY, USA
New York University, New York, NY, USA
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
ISPA - Instituto Universitário · Centro Champalimaud · William James Center for Research
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
William James Center for Research, ISPA–Instituto Universitario, Lisbon, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Champalimaud Foundation · Centro Champalimaud
Affiliation as printed
Champalimaud Center for the Unknown, Lisboa, Portugal
Champalimaud Foundation, Lisboa, Portugal
-
Anne E Urai Aachen Cognitive Psychology Unit Institute of Psychology and Leiden Institute for Brain and Cognition
Affiliation as printed
Cognitive Psychology Unit, Institute of Psychology and Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands
Leiden University, Leiden, The Netherlands
-
Affiliation as printed
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
-
Affiliation as printed
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
-
Affiliation as printed
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
-
Affiliation as printed
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
Watson School of Biological Science, Cold Spring Harbor, NY, USA
-
University of California, Berkeley
Affiliation as printed
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
University of California Berkeley, Berkeley, CA, USA
-
University of California, Berkeley
Affiliation as printed
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
University of California Berkeley, Berkeley, CA, USA
-
Affiliation as printed
Department of Applied Physics, Stanford University, Stanford, CA, USA
Stanford University, Stanford, CA, USA
-
Affiliation as printed
Department of Applied Physics, Stanford University, Stanford, CA, USA
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Basic Neuroscience, University of Geneva, Geneva, Switzerland
University of Geneva, Geneva, Switzerland
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
University of Washington, Seattle, WA, USA
-
Affiliation as printed
Department of Biological Structure, University of Washington, Seattle, WA, USA
-
Massachusetts Institute of Technology
Affiliation as printed
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
Massachusetts Institute of Technology, Cambridge, MA, USA
-
Massachusetts Institute of Technology
Affiliation as printed
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
-
Massachusetts Institute of Technology · Stanford University
Affiliation as printed
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
Stanford University, Stanford, CA, USA
-
University of California, Los Angeles
Affiliation as printed
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA
University of California Los Angeles, Los Angeles, CA, USA
-
University of California, Los Angeles
Affiliation as printed
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA
University of California Los Angeles, Los Angeles, CA, USA
-
University of California, Los Angeles
Affiliation as printed
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA
University of California Los Angeles, Los Angeles, CA, USA
-
University of California, Los Angeles
Affiliation as printed
Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA
-
Affiliation as printed
Department of Physiology, University of Yamanashi, Yamanashi, Japan
-
École Normale Supérieure - PSL
Affiliation as printed
Département D’études Cognitives, École Normale Supérieure, Paris, France
Département D'études Cognitives, École Normale Supérieure, Paris, France
-
École Normale Supérieure - PSL
Affiliation as printed
Département D’études Cognitives, École Normale Supérieure, Paris, France
Département D'études Cognitives, École Normale Supérieure, Paris, France
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
Gatsby Computational Neuroscience Unit · University College London
Affiliation as printed
Gatsby Computational Neuroscience Unit, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
University College London, London, UK
-
UCL Queen Square Institute of Neurology · University College London
Affiliation as printed
Institute of Neurology, University College London, London, UK
-
Affiliation as printed
Institute of Opthalmology, University College London, London, UK
University College London, London, UK
-
Affiliation as printed
Institute of Opthalmology, University College London, London, UK
-
Affiliation as printed
Institute of Opthalmology, University College London, London, UK
University College London, London, UK
-
Max Planck Institute for Biological Cybernetics · University of Tübingen
Affiliation as printed
Max Planck Institut, University of Tübingen, Tübingen, Germany
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Max Planck Institute for Biological Cybernetics · University of Tübingen
Affiliation as printed
Max Planck Institut, University of Tübingen, Tübingen, Germany
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Max Planck Institute for Biological Cybernetics · University of Tübingen
Affiliation as printed
Max Planck Institut, University of Tübingen, Tübingen, Germany
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Max Planck Institute for Biological Cybernetics
Affiliation as printed
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Max Planck Institute for Biological Cybernetics
Affiliation as printed
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Max Planck Institute for Biological Cybernetics
Affiliation as printed
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Princeton University · Cold Spring Harbor Laboratory
Affiliation as printed
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
Princeton University, Princeton, NJ, USA
-
Affiliation as printed
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA
Princeton University, Princeton, NJ, USA
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
-
Sainsbury Wellcome Centre · University College London
Affiliation as printed
Sainsbury Wellcome Centre, University College London, London, UK
Cited by 178 stored of 177
No patents citing this paper on Lens.org (checked 2026-10-11).