Disarming a molecular brake: cAMP-responsive element modulator deletion supercharges CAR-NK cells

Signal Transduction and Targeted Therapy, vol. 10, pp. 265

Abstract

In a recent study published in Nature , Rafei and colleagues identified the transcription factor cAMP responsive element modulator (CREM) as an important regulator in natural killer (NK) cells that have been engineered with Chimeric antigen receptors (CARs). Their study demonstrated that CREM integrates signals from CAR activation and from interleukin-15 (IL-15) stimulation and serves as a molecular brake that limits CAR-NK functionality. 1

Authors 2

1. Sudheendra Hebbar Subramanyam Aachen Department of Pediatrics, Translational Pediatric Rheumatology and Immunology

   RWTH Aachen University · Universitätsklinikum Aachen

   Affiliation as printed

   Department of Pediatrics, Translational Pediatric Rheumatology and Immunology, Rheinisch-Westfälische Technische Hochschule University Hospital, Aachen, Germany

2. Klaus Tenbrock corresponding Aachen Department of Pediatrics, Translational Pediatric Rheumatology and Immunology

   RWTH Aachen University · Universitätsklinikum Aachen · University of Bern · University Hospital of Bern

   Affiliation as printed

   Department of Pediatrics, Translational Pediatric Rheumatology and Immunology, Rheinisch-Westfälische Technische Hochschule University Hospital, Aachen, Germany. ktenbrock@ukaachen.de

   Division of Pediatric Rheumatology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. ktenbrock@ukaachen.de

   Department of Pediatrics, Translational Pediatric Rheumatology and Immunology, Rheinisch-Westfälische Technische Hochschule University Hospital, Aachen, Germany