Automated Deep Learning–based Segmentation of the Dentate Nucleus Using Quantitative Susceptibility Mapping MRI

Radiology Artificial Intelligence, vol. 7, pp. e240478

Abstract

A deep learning model using a two-step localization and segmentation pipeline accurately and reliably segmented the dentate nucleus using brain MRI–based quantitative susceptibility mapping images.

Authors 37

1. Diogo H. Shiraishi corresponding

   Universidade Estadual de Campinas (UNICAMP)

   Affiliation as printed

   Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

2. Susmita Saha corresponding

   Monash University

   Affiliation as printed

   Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia

   School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia

3. Isaac Mawusi Adanyeguh

   University of Minnesota

   Affiliation as printed

   Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn

4. Sirio Cocozza

   University of Naples Federico II

   Affiliation as printed

   Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy

5. Louise A. Corben

   The University of Melbourne · Murdoch Children's Research Institute · Monash University

   Affiliation as printed

   Bruce Lefroy Centre for Genetic Health Research, Murdoch Children’s Research Institute, Parkville, Australia

   Department of Paediatrics, University of Melbourne, Parkville, Australia

   School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia

   Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Australia

6. Andreas Deistung

   University Hospital in Halle · Martin Luther University Halle-Wittenberg

   Affiliation as printed

   Halle MR Imaging Core Facility, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

   University Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), University Medicine Halle, Halle (Saale), Germany

7. Martin Bruce Delatycki

   Murdoch Children's Research Institute

   Affiliation as printed

   Bruce Lefroy Centre for Genetic Health Research, Murdoch Children’s Research Institute, Parkville, Australia

   Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, Australia

8. Imis Dogan Aachen Department of Neurology JARA Brain Institute Molecular Neuroscience and Neuroimaging (INM-11)

   Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

   Affiliation as printed

   Department of Neurology, RWTH Aachen University, Aachen, Germany

   JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany

9. William C. Gaetz

   Children's Hospital of Philadelphia

   Affiliation as printed

   Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, Pa

   Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa

10. Nellie Georgiou‐Karistianis

    Monash University

    Affiliation as printed

    School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash University, Clayton, Australia

11. Simon Graf

    University Hospital in Halle

    Affiliation as printed

    University Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), University Medicine Halle, Halle (Saale), Germany

12. Marina Grisoli

    Fondazione IRCCS Istituto Neurologico Carlo Besta

    Affiliation as printed

    Department of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

13. Pierre‐Gilles Henry

    University of Minnesota

    Affiliation as printed

    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn

14. Gustavo M. Jarola

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

15. James M. Joers

    University of Minnesota

    Affiliation as printed

    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn

16. Christian Langkammer

    Medical University of Graz

    Affiliation as printed

    Department of Neurology, Medical University of Graz, Graz, Austria

17. Christophe Lenglet

    University of Minnesota

    Affiliation as printed

    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn

18. Jiakun Li

    University of Minnesota

    Affiliation as printed

    Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minn

19. Camila Caroso Lobo

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

20. Eric F. Lock

    University of Minnesota

    Affiliation as printed

    Division of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, Minn

21. David R. Lynch

    Children's Hospital of Philadelphia

    Affiliation as printed

    Department of Neurology, Children’s Hospital of Philadelphia, Philadelphia, Pa

    Department of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pa

22. Thomas H. Mareci

    University of Florida

    Affiliation as printed

    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Fla

23. Alberto Martínez

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

24. Serena Monti

    Institute of Biostructure and Bioimaging · National Research Council

    Affiliation as printed

    Institute of Biostructures and Bioimaging, Italian National Research Council, Naples, Italy

25. Anna Nigri

    Fondazione IRCCS Istituto Neurologico Carlo Besta

    Affiliation as printed

    Department of Neuroradiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

26. Massimo Pandolfo

    McGill University

    Affiliation as printed

    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

27. Kathrin Reetz Aachen Department of Neurology JARA Brain Institute Molecular Neuroscience and Neuroimaging (INM-11)

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Department of Neurology, RWTH Aachen University, Aachen, Germany

    JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany

28. Timothy P. L. Roberts

    Children's Hospital of Philadelphia

    Affiliation as printed

    Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, Pa

    Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa

29. Sandro Romanzetti Aachen Department of Neurology

    RWTH Aachen University

    Affiliation as printed

    Department of Neurology, RWTH Aachen University, Aachen, Germany

30. David A. Rudko

    Montreal Neurological Institute and Hospital · McGill University

    Affiliation as printed

    Department of Biomedical Engineering, McGill University, Montreal, Canada

    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada

    McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, Canada

31. Alessandra Scaravilli

    University of Naples Federico II

    Affiliation as printed

    Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy

32. Jörg Bernhard Schulz Aachen Department of Neurology JARA Brain Institute Molecular Neuroscience and Neuroimaging (INM-11)

    Forschungszentrum Jülich · Jülich Aachen Research Alliance · RWTH Aachen University

    Affiliation as printed

    Department of Neurology, RWTH Aachen University, Aachen, Germany

    JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany

33. Sub H. Subramony

    University of Florida Health · University of Florida

    Affiliation as printed

    Department of Neurology and the Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Fla

34. Dagmar Timmann

    Essen University Hospital · University of Duisburg-Essen

    Affiliation as printed

    Department of Neurology and Center for Translational and Behavioral Neuroscience (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany

35. Marcondes C. França

    Universidade Estadual de Campinas (UNICAMP)

    Affiliation as printed

    Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

36. Ian H. Harding corresponding

    QIMR Berghofer Medical Research Institute · Monash University

    Affiliation as printed

    QIMR Berghofer Medical Research Institute, Brisbane, Australia

    School of Translational Medicine, Monash University, Melbourne, Australia

37. Thiago Junqueira Ribeiro de Rezende corresponding

    Universidade Estadual de Campinas (UNICAMP) · Instituto Paulo Gontijo

    Affiliation as printed

    Department of Neurology, School of Medical Sciences, University of Campinas (Unicamp), Rua Vital Brasil, 89-99, Cidade Universitária “Zeferino Vaz”, Campinas, São Paulo, Brazil 13083-888

    Paulo Gontijo Institute, São Paulo, Brazil