Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial

Gut Microbes, vol. 17, pp. 2541035

Abstract

were associated with triglyceride levels after FMT. No further microbiota signatures were associated with FMT-treatment or response. Donor microbiota engraftment appeared donor-specific, but not treatment- or response-specific. In conclusion, FMT did not significantly affect hepatic steatosis, glucose tolerance, liver biochemistry, or gut microbiota signatures. Future studies should consider including patients with low microbiota diversity. Dutch Trial Register: NL-OMON48776; Central Committee on Research Involving Human Subjects: NL66705.058.18; Clinicaltrials.gov: NCT04465032.

Authors 11

1. Bas Groenewegen corresponding Aachen b Department of Gastroenterology and Hepatology

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   LUMC

   Leiden University Center of Infectious Diseases (LUCID) Medical Microbiology and Infection Prevention, Leiden University Medical Center (LUMC)

   b Department of Gastroenterology and Hepatology, LUMC, Leiden, The Netherlands

2. Merel M. Ruissen Aachen Department of Gastroenterology and Hepatology

   Leiden University Medical Center

   Affiliation as printed

   LUMC

   Department of Gastroenterology and Hepatology, LUMC, Leiden, The Netherlands

3. Emily M. Crossette

   Cambridge College

   Affiliation as printed

   Vedanta Biosciences Inc

   Vedanta Biosciences Inc, Cambridge, MA, USA

4. Rajita Menon

   Cambridge College

   Affiliation as printed

   Vedanta Biosciences Inc

   Vedanta Biosciences Inc, Cambridge, MA, USA

5. Amanda Prince

   Cambridge College

   Affiliation as printed

   Vedanta Biosciences Inc

   Vedanta Biosciences Inc, Cambridge, MA, USA

6. Jason M. Norman

   Cambridge College

   Affiliation as printed

   Vedanta Biosciences Inc

   Vedanta Biosciences Inc, Cambridge, MA, USA

7. Bart E.P.B. Ballieux Aachen Department of Clinical Chemistry

   Leiden University Medical Center

   Affiliation as printed

   LUMC

   Department of Clinical Chemistry, LUMC, Leiden, The Netherlands

8. Hildo J. Lamb Aachen Department of Radiology, LUMC

   Leiden University Medical Center

   Affiliation as printed

   LUMC

   Department of Radiology, LUMC, Leiden, The Netherlands

9. Elisabeth M. Terveer Aachen Netherlands Donor Feces Bank

   Leiden University · Leiden University Medical Center

   Affiliation as printed

   Leiden University Center of Infectious Diseases (LUCID) Medical Microbiology and Infection Prevention, Leiden University Medical Center (LUMC)

   Netherlands Donor Feces Bank, Leiden University Center of Infectious Diseases (LUCID) Medical Microbiology and Infection Prevention, Leiden University Medical Center (LUMC), Leiden, The Netherlands

10. Josbert J. Keller Aachen b Department of Gastroenterology and Hepatology

    Leiden University · Leiden University Medical Center · Medisch Centrum Haaglanden · Stichting Haaglanden Medisch Centrum

    Affiliation as printed

    Haaglanden Medical Center

    LUMC

    Leiden University Center of Infectious Diseases (LUCID) Medical Microbiology and Infection Prevention, Leiden University Medical Center (LUMC)

    Department of Gastroenterology and Hepatology, Haaglanden Medical Center, The Hague, The Netherlands

    b Department of Gastroenterology and Hepatology, LUMC, Leiden, The Netherlands

11. Maarten E. Tushuizen Aachen Department of Gastroenterology and Hepatology

    Leiden University Medical Center

    Affiliation as printed

    LUMC

    Department of Gastroenterology and Hepatology, LUMC, Leiden, The Netherlands