Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA ‐ PGC PTSD Study
Human Brain Mapping, vol. 46, pp. e70116
Abstract
Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (N = 1035) with and without PTSD from the ENIGMA-PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi-cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.
Authors 72
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Carissa W. Tomas corresponding
Affiliation as printed
Comprehensive Injury Center Medical College of Wisconsin Milwaukee Wisconsin USA
Division of Epidemiology and Social Sciences Institute of Health and Equity, Medical College of Wisconsin Milwaukee Wisconsin USA
Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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Affiliation as printed
Department of Psychology Marquette University Milwaukee Wisconsin USA
Department of Psychology, Marquette University, Milwaukee, Wisconsin, USA
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Duke University · Duke Medical Center · Durham VA Medical Center
Affiliation as printed
Brain Imaging and Analysis Center Duke University Durham North Carolina USA
Department of Veteran Affairs Mid‐Atlantic Mental Illness Research Education and Clinical Center Durham North Carolina USA
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA
Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina, USA
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Duke University · Duke Medical Center · Durham VA Medical Center
Affiliation as printed
Brain Imaging and Analysis Center Duke University Durham North Carolina USA
Department of Veteran Affairs Mid‐Atlantic Mental Illness Research Education and Clinical Center Durham North Carolina USA
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA
Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina, USA
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Baylor College of Medicine · Yale University
Affiliation as printed
Departments of Psychiatry and Psychology Yale University New Haven Connecticut USA
Division of Psychiatry Baylor College of Medicine Houston Texas USA
Departments of Psychiatry and Psychology, Yale University, New Haven, Connecticut, USA
Division of Psychiatry, Baylor College of Medicine, Houston, Texas, USA
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Harvard University · McLean Hospital
Affiliation as printed
Department of Psychiatry Harvard Medical School Boston Massachusetts USA
Institute for Technology in Psychiatry McLean Hospital Belmont Massachusetts USA
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts, USA
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Affiliation as printed
Department of Psychology University of Minnesota Minneapolis Minnesota USA
Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
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Vanderbilt University · Vanderbilt University Medical Center
Affiliation as printed
Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center Nashville Tennessee USA
Department of Psychology Vanderbilt University Nashville Tennessee USA
Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
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The University of Texas at Austin
Affiliation as printed
Department of Psychiatry University of Texas at Austin Austin Texas USA
Department of Psychiatry, University of Texas at Austin, Austin, Texas, USA
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Affiliation as printed
Department of Psychiatry University of Toledo Toledo Ohio USA
Department of Psychiatry, University of Toledo, Toledo, Ohio, USA
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Affiliation as printed
Department of Clinical Psychology University of Groningen Groningen The Netherlands
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands
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University of Minnesota · Minneapolis VA Health Care System · Minneapolis VA Medical Center
Affiliation as printed
Department of Psychiatry and Behavioral Sciences University of Minnesota Minneapolis Minnesota USA
Minneapolis VA Health Care System Minneapolis Minnesota USA
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA
Minneapolis VA Health Care System, Minneapolis, Minnesota, USA
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University of Wisconsin–Madison
Affiliation as printed
Center for Healthy Minds University of Wisconsin‐Madison Madison Wisconsin USA
Department of Psychiatry University of Wisconsin‐Madison Madison Wisconsin USA
Department of Psychology University of Wisconsin‐Madison Madison Wisconsin USA
Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Affiliation as printed
Comprehensive Injury Center Medical College of Wisconsin Milwaukee Wisconsin USA
Division of Trauma and Acute Care Surgery, Department of Surgery Medical College of Wisconsin Milwaukee Wisconsin USA
Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
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University of Minnesota · Minneapolis VA Health Care System · Minneapolis VA Medical Center
Affiliation as printed
Department of Psychiatry and Behavioral Sciences University of Minnesota Minneapolis Minnesota USA
Minneapolis VA Health Care System Minneapolis Minnesota USA
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA
Minneapolis VA Health Care System, Minneapolis, Minnesota, USA
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Université de Tours · Inserm · Centre Hospitalier Universitaire de Tours · Clinical Investigation Center Plurithematic Tours
Affiliation as printed
CIC1415, CHRU de Tours, INSERM Tours France
UMR1253 Université de Tours, INSERM Tours France
UMR1253 Université de Tours, INSERM Tours France
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Washington University in St. Louis
Affiliation as printed
Department of Radiology Washington University School of Medicine St. Louis Missouri USA
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
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University of Wisconsin–Madison
Affiliation as printed
Department of Psychiatry University of Wisconsin‐Madison Madison Wisconsin USA
Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Department of Psychiatry Columbia University Medical Center New York New York USA
New York State Psychiatric Institute New York New York USA
Department of Psychiatry, Columbia University Medical Center, New York, New York, USA
New York State Psychiatric Institute, New York, New York, USA
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University of Wisconsin–Madison
Affiliation as printed
School of Medicine and Public Health University of Wisconsin Madison Madison Wisconsin USA
School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
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Affiliation as printed
Institute of Medical Psychology and Systems Neuroscience University of Münster Münster Germany
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University of Arizona · Duke University · Duke Medical Center · Durham VA Medical Center
Affiliation as printed
Brain Imaging and Analysis Center Duke University Durham North Carolina USA
Department of Psychology University of Arizona Tucson Arizona USA
Department of Veteran Affairs Mid‐Atlantic Mental Illness Research Education and Clinical Center Durham North Carolina USA
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA
Department of Psychology, University of Arizona, Tucson, Arizona, USA
Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina, USA
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Duke University · Duke Medical Center · Durham VA Medical Center
Affiliation as printed
Brain Imaging and Analysis Center Duke University Durham North Carolina USA
Department of Veteran Affairs Mid‐Atlantic Mental Illness Research Education and Clinical Center Durham North Carolina USA
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA
Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina, USA
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South African Medical Research Council · University of Cape Town
Affiliation as printed
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
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University of Southern California
Affiliation as printed
Imaging Genetics Center Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC Marina del Rey California USA
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA
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Emory University · Wayne State University
Affiliation as printed
Department of Psychiatry and Behavioral Neuroscience Wayne State University School of Medicine Detroit Michigan USA
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, Michigan, USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
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Harvard University · McLean Hospital
Affiliation as printed
Department of Psychiatry Harvard Medical School Boston Massachusetts USA
Division of Women's Mental Health McLean Hospital Belmont Massachusetts USA
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Division of Women's Mental Health, McLean Hospital, Belmont, Massachusetts, USA
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New York State Psychiatric Institute
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New York State Psychiatric Institute New York New York USA
New York State Psychiatric Institute, New York, New York, USA
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Affiliation as printed
Department of Psychiatry University of Michigan Ann Arbor Michigan USA
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
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Radboud University Nijmegen · Amsterdam Neuroscience · Amsterdam University Medical Centers · Donders Centre for Cognitive Neuroimaging · Donders Institute for Brain, Cognition and Behaviour · University of Amsterdam
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Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Donders Institute for Brain, Cognition and Behavior Centre for Cognitive Neuroimaging, Radboud University Nijmegen Nijmegen The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
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South African Medical Research Council · University of Cape Town
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SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
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Affiliation as printed
Tel‐Aviv University Tel Aviv‐Yafo Israel
Tel-Aviv University, Tel Aviv-Yafo, Israel
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Harvard University · McLean Hospital
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Department of Psychiatry Harvard Medical School Boston Massachusetts USA
Division of Depression and Anxiety Disorders McLean Hospital Belmont Massachusetts USA
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, Massachusetts, USA
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Affiliation as printed
Department of Psychiatry Texas A&M University Bryan Texas USA
Department of Psychiatry, Texas A&M University, Bryan, Texas, USA
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Affiliation as printed
Department of Psychology University of Minnesota Minneapolis Minnesota USA
Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
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Charité - Universitätsmedizin Berlin
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University Medical Centre Charité Berlin Germany
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Affiliation as printed
Department of Psychology Harvard University Cambridge Massachusetts USA
Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Department of Psychiatry Columbia University Medical Center New York New York USA
New York State Psychiatric Institute New York New York USA
Department of Psychiatry, Columbia University Medical Center, New York, New York, USA
New York State Psychiatric Institute, New York, New York, USA
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University of Wisconsin–Madison
Affiliation as printed
Department of Psychology University of Wisconsin‐Madison Madison Wisconsin USA
Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA
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Affiliation as printed
Department of Psychology Vanderbilt University Nashville Tennessee USA
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA
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Arq Psychotrauma Expert Group · Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
ARQ National Psychotrauma Centre Diemen The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
ARQ National Psychotrauma Centre, Diemen, The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Affiliation as printed
Department of Psychology University of Washington Seattle Washington USA
Department of Psychology, University of Washington, Seattle, Washington, USA
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UNSW Sydney · Neuroscience Research Australia
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Neuroscience Research Australia Randwick New South Wales Australia
School of Psychology University of New South Wales (UNSW) Sydney Sydney New South Wales Australia
Neuroscience Research Australia, Randwick, New South Wales, Australia
School of Psychology, University of New South Wales (UNSW) Sydney, Sydney, New South Wales, Australia
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New York State Psychiatric Institute
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New York State Psychiatric Institute New York New York USA
New York State Psychiatric Institute, New York, New York, USA
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Harvard University · Emory University · McLean Hospital
Affiliation as printed
Department of Psychiatry Harvard Medical School Boston Massachusetts USA
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
Division of Depression and Anxiety Disorders McLean Hospital Belmont Massachusetts USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, Massachusetts, USA
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Affiliation as printed
Northwestern Neighborhood and Network Initiative Northwestern University Institute for Policy Research Evanston Illinois USA
Northwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, Illinois, USA
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University of Southern California
Affiliation as printed
Imaging Genetics Center Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC Marina del Rey California USA
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA
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Affiliation as printed
Department of Radiology University of Washington Seattle Washington USA
Department of Radiology, University of Washington, Seattle, Washington, USA
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Affiliation as printed
Department of Psychiatry University of Toledo Toledo Ohio USA
Department of Psychiatry, University of Toledo, Toledo, Ohio, USA
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Charité - Universitätsmedizin Berlin
Affiliation as printed
University Medical Centre Charité Berlin Germany
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University of Minnesota · Minneapolis VA Health Care System · Minneapolis VA Medical Center
Affiliation as printed
Department of Psychiatry and Behavioral Sciences University of Minnesota Minneapolis Minnesota USA
Minneapolis VA Health Care System Minneapolis Minnesota USA
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA
Minneapolis VA Health Care System, Minneapolis, Minnesota, USA
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South African Medical Research Council · University of Cape Town
Affiliation as printed
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute University of Cape Town Cape Town South Africa
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
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Affiliation as printed
Institute of Medical Psychology and Systems Neuroscience University of Münster Münster Germany
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University of Rochester Medicine
Affiliation as printed
Department of Neuroscience University of Rochester Medical Center Rochester New York USA
Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA
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University of Southern California
Affiliation as printed
Imaging Genetics Center Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC Marina del Rey California USA
Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA
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Nic J.A. van der Wee Aachen Department of Psychiatry Leiden University Medical Center Leiden The Netherlands Leiden Institute for Brain and Cognition Leiden The Netherlands Department of Psychiatry, Leiden University Medical Center Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
Leiden Institute for Brain and Cognition Leiden The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Steven J.A. van der Werff Aachen Department of Psychiatry Leiden University Medical Center Leiden The Netherlands Leiden Institute for Brain and Cognition Leiden The Netherlands Department of Psychiatry, Leiden University Medical Center Leiden Institute for Brain and Cognition
Leiden University · Leiden University Medical Center
Affiliation as printed
Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
Leiden Institute for Brain and Cognition Leiden The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Affiliation as printed
Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta Georgia USA
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Amsterdam Neuroscience · Amsterdam University Medical Centers · University of Amsterdam
Affiliation as printed
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience Amsterdam The Netherlands
Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands
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Robert R. J. M. Vermeiren Aachen Department of Psychiatry Leiden University Medical Center Leiden The Netherlands Department of Psychiatry, Leiden University Medical Center
Leiden University Medical Center
Affiliation as printed
Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
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Charité - Universitätsmedizin Berlin
Affiliation as printed
University Medical Centre Charité Berlin Germany
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Affiliation as printed
Department of Psychiatry University of Toledo Toledo Ohio USA
Department of Psychiatry, University of Toledo, Toledo, Ohio, USA
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Affiliation as printed
Department of Psychiatry University of Toledo Toledo Ohio USA
Department of Psychiatry, University of Toledo, Toledo, Ohio, USA
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Columbia University Irving Medical Center · New York State Psychiatric Institute
Affiliation as printed
Department of Psychiatry Columbia University Medical Center New York New York USA
New York State Psychiatric Institute New York New York USA
Department of Psychiatry, Columbia University Medical Center, New York, New York, USA
New York State Psychiatric Institute, New York, New York, USA
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Affiliation as printed
University of Haifa Haifa Israel
University of Haifa, Haifa, Israel
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University of Wisconsin–Milwaukee
Affiliation as printed
Department of Psychology University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA
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Duke University · Duke Medical Center · Durham VA Medical Center
Affiliation as printed
Brain Imaging and Analysis Center Duke University Durham North Carolina USA
Department of Veteran Affairs Mid‐Atlantic Mental Illness Research Education and Clinical Center Durham North Carolina USA
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA
Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, North Carolina, USA
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